ES8703895A1 - Procedimiento para preparar anticuerpos monoclonales y deri-vados de los mismos - Google Patents

Procedimiento para preparar anticuerpos monoclonales y deri-vados de los mismos

Info

Publication number
ES8703895A1
ES8703895A1 ES546564A ES546564A ES8703895A1 ES 8703895 A1 ES8703895 A1 ES 8703895A1 ES 546564 A ES546564 A ES 546564A ES 546564 A ES546564 A ES 546564A ES 8703895 A1 ES8703895 A1 ES 8703895A1
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
derivatives
processes
glycoconjugates
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546564A
Other languages
English (en)
Other versions
ES546564A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421944A external-priority patent/GB8421944D0/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8703895A1 publication Critical patent/ES8703895A1/es
Publication of ES546564A0 publication Critical patent/ES546564A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ANTICUERPOS MONOCLONALES Y DERIVADOS DE LOS MISMOS. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, LAS CELULAS DE HIBRIDOMAS DERIVADAS DE RATONES BALB/C QUE SEGREGAN LOS ANTICUERPOS DESEADOS, SE INYECTAN INTRAPERITONEALMENTE EN RATONES BALB/C OPCIONALMENTE TRATADOS PREVIAMENTE CON UN HIDROCARBURO; SEGUNDA, DESPUES DE UNA O DOS SEMANAS SE RECOGE EL FLUIDO ASCITICO DE ESTOS RATONES Y SE AISLAN LOS ANTICUERPOS MONOCLONALES DEL MISMO POR PRECIPITACION CON SULFATO AMONICO O POR METODOS CROMATOGRAFICOS CONVENCIONALES; Y POR ULTIMO, SE TRANSFORMAN LOS ANTICUERPOS MONOCLONALES OBTENIDOS EN UN DERIVADO DE LOS MISMOS. DE APLICACION EN LA DIAGNOSIS Y TRATAMIENTO DEL CANCER.
ES546564A 1984-08-30 1985-08-30 Procedimiento para preparar anticuerpos monoclonales y deri-vados de los mismos Expired ES8703895A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421944A GB8421944D0 (en) 1984-08-30 1984-08-30 Monoclonal antibodies
GB858515538A GB8515538D0 (en) 1984-08-30 1985-06-19 Monoclonal antibodies

Publications (2)

Publication Number Publication Date
ES8703895A1 true ES8703895A1 (es) 1987-03-01
ES546564A0 ES546564A0 (es) 1987-03-01

Family

ID=26288164

Family Applications (2)

Application Number Title Priority Date Filing Date
ES546564A Expired ES8703895A1 (es) 1984-08-30 1985-08-30 Procedimiento para preparar anticuerpos monoclonales y deri-vados de los mismos
ES555613A Expired ES8800845A1 (es) 1984-08-30 1986-06-02 Procedimiento para preparar anticuerpos monoclonales y derivados de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES555613A Expired ES8800845A1 (es) 1984-08-30 1986-06-02 Procedimiento para preparar anticuerpos monoclonales y derivados de los mismos

Country Status (11)

Country Link
EP (1) EP0173648A3 (es)
AU (1) AU4688785A (es)
DK (1) DK391785A (es)
ES (2) ES8703895A1 (es)
FI (1) FI853283L (es)
GR (1) GR852099B (es)
HU (1) HUT38391A (es)
IL (1) IL76247A0 (es)
NO (1) NO853397L (es)
NZ (1) NZ213293A (es)
PT (1) PT81040B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202252A (en) * 1982-03-05 1993-04-13 Houston Biotechnology Inc. Monoclonal antibodies against lens epithelial cells and methods for preventing proliferation of remnant lens epithelial cells after extracapsular extraction
US5055291A (en) * 1986-11-04 1991-10-08 Baylor College Of Medicine Compositions for preventing secondary cataracts
CA1338777C (en) * 1986-11-04 1996-12-10 Dominic Man-Kit Lam Methods and compositions for preventing secondary cataracts
US5616122A (en) * 1986-11-04 1997-04-01 Baylor College Of Medicine Methods and compositions for preventing secondary cataracts
US5104652A (en) * 1986-11-13 1992-04-14 Sloan-Kettering Institute For Cancer Research Compositions and method for treatment of cancer using monoclonal antibody against GD3 ganglioside together with IL-2
US5237054A (en) * 1987-02-20 1993-08-17 Akzo Pharma Stabilized aqueous composition containing antibodies
ATE83930T1 (de) * 1987-02-20 1993-01-15 Akzo Nv Antikoerper enthaltende stabilisierte waesserige zusammensetzung.
US5073493A (en) * 1987-05-29 1991-12-17 Ikuo Yamashina Monoclonal antibody nky13
AU2489888A (en) * 1987-09-08 1989-04-17 Biomembrane Institute, The Detection of survived, undegraded carbohydrate epitopes as diagnostic of intestinal diseases
US5030723A (en) * 1988-05-31 1991-07-09 The Biomembrane Institute Long-chain glycolipid structure
US5242824A (en) * 1988-12-22 1993-09-07 Oncogen Monoclonal antibody to human carcinomas
AU781171B2 (en) * 1997-06-10 2005-05-12 Lpath Therapeutics, Inc. Methods for early detection of heart disease
CA2432978C (en) * 2000-12-22 2012-08-28 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US20080138334A1 (en) 2006-05-31 2008-06-12 Sabbadini Roger A Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same
CN101687031B (zh) 2006-10-27 2014-05-14 勒帕斯公司 用于治疗眼疾和眼病的组合物及方法
AU2007329759B2 (en) 2006-10-27 2013-05-30 Lpath, Inc. Compositions and methods for binding sphingosine-1-phosphate
US8361465B2 (en) * 2007-10-26 2013-01-29 Lpath, Inc. Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906562A (en) * 1984-12-21 1990-03-06 Oncogen Monocolonal antibodies and antigen for human non-small cell lung carcinomas
EP0209493A3 (en) * 1985-07-16 1988-05-04 Ciba-Geigy Ag Prophylaxis and treatment of whooping cough

Also Published As

Publication number Publication date
EP0173648A2 (en) 1986-03-05
EP0173648A3 (en) 1988-04-27
FI853283L (fi) 1986-03-01
HUT38391A (en) 1986-05-28
IL76247A0 (en) 1986-01-31
FI853283A0 (fi) 1985-08-28
NZ213293A (en) 1988-11-29
PT81040A (en) 1985-09-01
PT81040B (en) 1987-06-24
ES8800845A1 (es) 1987-12-01
DK391785A (da) 1986-03-01
DK391785D0 (da) 1985-08-29
GR852099B (es) 1986-01-02
NO853397L (no) 1986-03-03
ES555613A0 (es) 1987-12-01
ES546564A0 (es) 1987-03-01
AU4688785A (en) 1986-03-06

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