ES8703477A1 - Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482. - Google Patents

Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482.

Info

Publication number
ES8703477A1
ES8703477A1 ES544482A ES544482A ES8703477A1 ES 8703477 A1 ES8703477 A1 ES 8703477A1 ES 544482 A ES544482 A ES 544482A ES 544482 A ES544482 A ES 544482A ES 8703477 A1 ES8703477 A1 ES 8703477A1
Authority
ES
Spain
Prior art keywords
protected
hydroxymethyl
hydroxy
pharmaceutical composition
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544482A
Other languages
English (en)
Other versions
ES544482A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848416141A external-priority patent/GB8416141D0/en
Priority claimed from GB858510378A external-priority patent/GB8510378D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8703477A1 publication Critical patent/ES8703477A1/es
Publication of ES544482A0 publication Critical patent/ES544482A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO TETRACICLICO DENOMINADO FR-900482, DE FORMULA GENERAL (I). CONSISTE EN CULTIVAR EN CONDICIONES AEROBIAS UNA CEPA PRODUCTORA DEL COMPUESTO FR-900482, QUE PERTENECE AL GENERO STREPTOMYCES, EN UN MEDIO NUTRIENTE ACUOSO QUE CONTIENE FUENTES DE CARBONO Y NITROGENO ASIMILABLES. EL CULTIVO DE DICHA SEPA SE EFECTUA A UNA TEMPERATURA COMPRENDIDA ENTRE 20 Y 40 GRADOS. EL COMPUESTO FR-900482 PRODUCIDO SE RECUPERA A PARTIR DEL CULTIVO. DE APLICACION EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE TUMORES, ENFERMEDADES INFECCIOSAS Y SIMILARES.
ES544482A 1984-06-25 1985-06-24 Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482. Expired ES8703477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848416141A GB8416141D0 (en) 1984-06-25 1984-06-25 Fr-900482 substance
GB858510378A GB8510378D0 (en) 1985-04-24 1985-04-24 Tetracyclo compounds

Publications (2)

Publication Number Publication Date
ES8703477A1 true ES8703477A1 (es) 1987-02-16
ES544482A0 ES544482A0 (es) 1987-02-16

Family

ID=26287918

Family Applications (2)

Application Number Title Priority Date Filing Date
ES544482A Expired ES8703477A1 (es) 1984-06-25 1985-06-24 Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482.
ES552029A Expired ES8707961A1 (es) 1984-06-25 1986-02-14 Un procedimiento para preparar nuevos compuestos de 14-oxa-1, 11-diazatetraciclo (7.4.1.0-2,7.o-10,12)tetradeca-2,4,6-trieno.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552029A Expired ES8707961A1 (es) 1984-06-25 1986-02-14 Un procedimiento para preparar nuevos compuestos de 14-oxa-1, 11-diazatetraciclo (7.4.1.0-2,7.o-10,12)tetradeca-2,4,6-trieno.

Country Status (9)

Country Link
US (2) US4645765A (es)
EP (1) EP0166389B1 (es)
JP (3) JPH078872B1 (es)
KR (1) KR920009527B1 (es)
AU (1) AU584097B2 (es)
CA (1) CA1248897A (es)
DE (1) DE3577850D1 (es)
DK (1) DK170892B1 (es)
ES (2) ES8703477A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK733888A (da) * 1988-01-12 1989-07-13 Fujisawa Pharmaceutical Co Stabiliseringsmiddel
US4973693A (en) * 1989-09-01 1990-11-27 Shunsuke Goto Novel pentacyclic compound and stereoselective synthesis thereof
KR20000049023A (ko) * 1996-10-29 2000-07-25 후지야마 아키라 Ｆｒ900482 및 유사 화합물의 신규한 제조방법
JP2003171280A (ja) * 1999-06-07 2003-06-17 Fujisawa Pharmaceut Co Ltd 抗腫瘍効果増強剤
WO2001097812A1 (fr) * 2000-06-20 2001-12-27 Fujisawa Pharmaceutical Co., Ltd. Preparations pharmaceutiques contenant des composes tetracycliques
KR100768476B1 (ko) 2005-11-24 2007-10-18 한국해양연구원 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물
US9896457B2 (en) 2013-08-29 2018-02-20 Op Bio Factory Co., Ltd. Microbial product having antifungal activity
CN111793015B (zh) * 2020-07-14 2021-08-27 遵义医科大学 一种含氮三元环化合物Strepmycin A及其分离方法和抗菌应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB974168A (en) * 1961-06-26 1964-11-04 Ici Ltd Manufacture of 2-ª‰-methoxyethylpyridine
US4313935A (en) * 1979-03-05 1982-02-02 Fujisawa Pharmaceutical Co., Ltd. Antibiotic FR-900129 substance, a process for the preparation thereof and pharmaceutical compositions containing the same
JPS56128774A (en) * 1980-03-14 1981-10-08 Microbial Chem Res Found New physiologically active substance ebelactone and its preparation

Also Published As

Publication number Publication date
DK285585A (da) 1985-12-26
DK285585D0 (da) 1985-06-24
JPH078872B1 (es) 1995-02-01
ES8707961A1 (es) 1987-09-01
ES552029A0 (es) 1987-09-01
JPH0767623A (ja) 1995-03-14
KR920009527B1 (ko) 1992-10-17
AU4372885A (en) 1986-01-02
US4743555A (en) 1988-05-10
JPH01199975A (ja) 1989-08-11
EP0166389A1 (en) 1986-01-02
JPH07102128B2 (ja) 1995-11-08
AU584097B2 (en) 1989-05-18
CA1248897A (en) 1989-01-17
DK170892B1 (da) 1996-03-04
KR860000385A (ko) 1986-01-28
US4645765A (en) 1987-02-24
DE3577850D1 (de) 1990-06-28
ES544482A0 (es) 1987-02-16
EP0166389B1 (en) 1990-05-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100623