ES8703469A1 - Un procedimiento para preparar pirazol(3,4,5-kl)acridinas - Google Patents

Un procedimiento para preparar pirazol(3,4,5-kl)acridinas

Info

Publication number
ES8703469A1
ES8703469A1 ES550775A ES550775A ES8703469A1 ES 8703469 A1 ES8703469 A1 ES 8703469A1 ES 550775 A ES550775 A ES 550775A ES 550775 A ES550775 A ES 550775A ES 8703469 A1 ES8703469 A1 ES 8703469A1
Authority
ES
Spain
Prior art keywords
pyrazolo
pharmaceutical compositions
processes
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550775A
Other languages
English (en)
Other versions
ES550775A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES550775A0 publication Critical patent/ES550775A0/es
Publication of ES8703469A1 publication Critical patent/ES8703469A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PIRAZOL3,4,5-KLACRIDINAS. CONSISTE EN HACER REACCIONAR UNA 1-CLORO-4-NITRO-9(10)-ACRIDONA DE FORMULA (II) CON DOS EQUIVALENTES DE UNA HIDRAZINA SUSTITUIDA POR R2 QUE TIENE LA FORMULA H2NNHR2 Y AISLAR EL PRODUCTO EN FORMA DE BASE LIBRE O EN FORMA DE SAL FARMACEUTICAMENTE ACEPTABLE PARA OBTENER PIRAZOL3,4,5-KLACRIDINAS DE FORMULA (I) DONDE R2 ES ALQUILEN-NRXRY EN DONDE RX Y RY SON INDIVIDUAL E INDEPENDIENTEMENTE H, ALQUILO Y OTROS; R6 ES H O ALQUILO DE CADENA RECTA O RAMIFICADA CON C 1 A 3; Y RA ES H O UNO DE DOS GRUPOS SELECCIONADOS DE HIDROXILO, CLORO, AMINO, ALQUILAMINO O DIALQUILAMINO DE C 1 A 4 Y OTROS. TIENEN UTILIDAD COMO AGENTES ANTIMICROBIANOS Y ANTITUMORALES.
ES550775A 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas Expired ES8703469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51512583A 1983-07-19 1983-07-19
US06/619,258 US4555572A (en) 1983-07-19 1984-06-15 Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use

Publications (2)

Publication Number Publication Date
ES550775A0 ES550775A0 (es) 1987-02-16
ES8703469A1 true ES8703469A1 (es) 1987-02-16

Family

ID=27058407

Family Applications (5)

Application Number Title Priority Date Filing Date
ES534414A Expired ES8701758A1 (es) 1983-07-19 1984-07-18 Un procedimiento para preparar pirazolo (3, 4, 5-kl) acridinas
ES550776A Expired ES8703874A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas
ES550775A Expired ES8703469A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas
ES550774A Expired ES8703468A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol (3,4,5-kl)acridinas
ES550777A Expired ES8703875A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES534414A Expired ES8701758A1 (es) 1983-07-19 1984-07-18 Un procedimiento para preparar pirazolo (3, 4, 5-kl) acridinas
ES550776A Expired ES8703874A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES550774A Expired ES8703468A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol (3,4,5-kl)acridinas
ES550777A Expired ES8703875A1 (es) 1983-07-19 1986-01-10 Un procedimiento para preparar pirazol(3,4,5-kl)acridinas

Country Status (11)

Country Link
US (1) US4555572A (es)
EP (1) EP0138302B1 (es)
JP (2) JPS6069084A (es)
AT (1) ATE32897T1 (es)
AU (1) AU569532B2 (es)
CA (1) CA1271476A (es)
DE (1) DE3469740D1 (es)
DK (1) DK161384C (es)
ES (5) ES8701758A1 (es)
GR (1) GR79958B (es)
IE (1) IE57712B1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868191A (en) * 1988-03-03 1989-09-19 Harbor Branch Oceanographic Institution, Inc. Alkaloid compounds, and pharmaceutical compositions containing them
JP2795460B2 (ja) * 1988-06-20 1998-09-10 協和醗酵工業株式会社 ピラゾロアクリドン誘導体
GB8923075D0 (en) * 1989-10-13 1989-11-29 Patterson Laurence H Anti-cancer compounds
GB9107843D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9107852D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
US5319460A (en) * 1991-08-29 1994-06-07 Canon Kabushiki Kaisha Image signal processing device including frame memory
IT1293523B1 (it) * 1997-08-01 1999-03-01 Uni Degli Studi Camerino Derivati di pirazolo-acridine aventi attivita' antitumorale
US7609669B2 (en) 2005-02-14 2009-10-27 Vocollect, Inc. Voice directed system and method configured for assured messaging to multiple recipients
CN104860945B (zh) * 2014-02-25 2016-08-24 北京大学 稠合吖啶衍生物及其药物组合物、制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009079A1 (es) * 1968-05-22 1970-01-30 Sandoz Sa
DE1811409A1 (de) * 1968-11-28 1970-06-18 Bayer Ag Mittel zur Bekaempfung von Insekten,Milben,Hasenartigen und Nagetieren
PL106752B1 (pl) * 1976-02-25 1980-01-31 Politechnika Gdanska Sposob otrzymywania nowych 1-nitro-9-alkiloaminoalkiloaminoakrydyn lub ich soli

Also Published As

Publication number Publication date
ES550776A0 (es) 1987-03-01
DK351484D0 (da) 1984-07-18
ES8703468A1 (es) 1987-02-16
JPS6069084A (ja) 1985-04-19
DK351484A (da) 1985-01-20
ES550777A0 (es) 1987-03-01
JPH0730076B2 (ja) 1995-04-05
CA1271476A (en) 1990-07-10
AU569532B2 (en) 1988-02-04
JPH0641127A (ja) 1994-02-15
IE57712B1 (en) 1993-03-10
GR79958B (es) 1984-10-31
JPH0559916B2 (es) 1993-09-01
ES8701758A1 (es) 1986-12-01
ES8703874A1 (es) 1987-03-01
DK161384C (da) 1992-01-06
ES550775A0 (es) 1987-02-16
AU3056484A (en) 1985-01-24
US4555572A (en) 1985-11-26
ES534414A0 (es) 1986-12-01
DK161384B (da) 1991-07-01
IE841617L (en) 1985-01-19
ATE32897T1 (de) 1988-03-15
EP0138302B1 (en) 1988-03-09
DE3469740D1 (en) 1988-04-14
EP0138302A1 (en) 1985-04-24
ES8703875A1 (es) 1987-03-01
ES550774A0 (es) 1987-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20061120