ES8701722A1 - Un procedimiento para preparar derivados de acidos carboxilicos - Google Patents

Un procedimiento para preparar derivados de acidos carboxilicos

Info

Publication number
ES8701722A1
ES8701722A1 ES554040A ES554040A ES8701722A1 ES 8701722 A1 ES8701722 A1 ES 8701722A1 ES 554040 A ES554040 A ES 554040A ES 554040 A ES554040 A ES 554040A ES 8701722 A1 ES8701722 A1 ES 8701722A1
Authority
ES
Spain
Prior art keywords
condensed
lower alkyl
membered ring
ring compounds
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554040A
Other languages
English (en)
Other versions
ES554040A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000119 external-priority patent/WO1985004402A1/ja
Priority claimed from PCT/JP1984/000172 external-priority patent/WO1985004657A1/ja
Priority claimed from PCT/JP1984/000363 external-priority patent/WO1986000618A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8701722A1 publication Critical patent/ES8701722A1/es
Publication of ES554040A0 publication Critical patent/ES554040A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDOS CARBOXILICOS O ALGUNA DE SUS SALES, DE FORMULA R6-A-E-COOR3 (I) EN LA QUE R3 ES H, ALQUILO INFERIOR O ARALQUILO; R6 ES 4-PIPERIDILO; A UNA CADENA DE ALQUILENO Y E ES CFO O UN GRUPO C-WA SIENDO WA HALOGENO O UN GRUPO RASO2-O- Y RA ES ALQUILO INFERIOR, F3CH3, FENILO O P-TOLILO. COMPRENDE HACER REACCIONAR UN COMPUESTO R6-A-COOR3 Y UN COMPUESTO R3LOOC-COORL, EN QUE R3, R6 Y A SON LOS ANTES DEFINIDOS Y RL ES ALQUILO INFERIOR O ARALQUILO, EN PRESENCIA DE UNA BASE, SEGUIDO DE CALENTAMIENTO Y SI SE DESEA TRANSFORMAR EL COMPUESTO (I) EN ALGUNA DE SUS SALES. DE APLICACION EN FARMACOS PARA EL TRATAMIENTO DE ENFERMEDADES CIRCULATORIAS COMO HIPERTENSION, CARDIOPATIA Y APOPLEJIA CEREBRAL.43
ES554040A 1984-03-24 1986-04-16 Un procedimiento para preparar derivados de acidos carboxilicos Expired ES8701722A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP1984/000119 WO1985004402A1 (en) 1984-03-24 1984-03-24 Fused 7-membered ring compounds and process for their preparation
PCT/JP1984/000172 WO1985004657A1 (en) 1984-04-06 1984-04-06 Fused 7-membered ring compounds and process for their preparation
PCT/JP1984/000363 WO1986000618A1 (en) 1984-07-13 1984-07-13 Condensed 7-membered ring compounds and process for their preparation

Publications (2)

Publication Number Publication Date
ES8701722A1 true ES8701722A1 (es) 1986-12-01
ES554040A0 ES554040A0 (es) 1986-12-01

Family

ID=27304396

Family Applications (2)

Application Number Title Priority Date Filing Date
ES554039A Expired ES8801635A1 (es) 1984-03-24 1986-04-16 Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-tetrahidro-1,5-benzoxazepina.
ES554040A Expired ES8701722A1 (es) 1984-03-24 1986-04-16 Un procedimiento para preparar derivados de acidos carboxilicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES554039A Expired ES8801635A1 (es) 1984-03-24 1986-04-16 Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-tetrahidro-1,5-benzoxazepina.

Country Status (7)

Country Link
US (1) US4739066A (es)
KR (1) KR910009201B1 (es)
AR (1) AR241112A1 (es)
DK (1) DK33385A (es)
ES (2) ES8801635A1 (es)
PH (1) PH25131A (es)
PT (1) PT79931B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450248A (en) * 1980-09-08 1984-05-22 Phoenix Chemical Corporation Hindered piperidyl light stabilizers
US4638800A (en) * 1985-02-08 1987-01-27 Research Physics, Inc Laser beam surgical system

Also Published As

Publication number Publication date
KR910009201B1 (ko) 1991-11-04
PT79931A (en) 1985-03-01
ES8801635A1 (es) 1988-02-16
PH25131A (en) 1991-02-19
DK33385A (da) 1985-09-23
AR241112A2 (es) 1991-11-15
ES554040A0 (es) 1986-12-01
PT79931B (en) 1987-05-13
DK33385D0 (da) 1985-01-25
KR850006412A (ko) 1985-10-05
ES554039A0 (es) 1988-02-16
AR241112A1 (es) 1991-11-15
US4739066A (en) 1988-04-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603