ES8700247A1 - Un metodo para preparar una cromona-5 sustituida. - Google Patents

Un metodo para preparar una cromona-5 sustituida.

Info

Publication number
ES8700247A1
ES8700247A1 ES543515A ES543515A ES8700247A1 ES 8700247 A1 ES8700247 A1 ES 8700247A1 ES 543515 A ES543515 A ES 543515A ES 543515 A ES543515 A ES 543515A ES 8700247 A1 ES8700247 A1 ES 8700247A1
Authority
ES
Spain
Prior art keywords
thiochromones
carbon atoms
image
lower alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543515A
Other languages
English (en)
Other versions
ES543515A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of ES543515A0 publication Critical patent/ES543515A0/es
Publication of ES8700247A1 publication Critical patent/ES8700247A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D335/16—Oxygen atoms, e.g. thioxanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cylinder Crankcases Of Internal Combustion Engines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Lubricants (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Ceramic Products (AREA)

Abstract

METODO PARA PREPARAR UNA CROMONA 5-SUSTITUIDA DE FORMULA (I) Y DESCRIPCION DE CIERTAS CROMONAS Y TIOCROMONAS 5-SUSTITUIDAS Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES. LAS CROMONAS 5-SUSTITUIDAS SE PREPARAN CONVENIENTEMENTE A PARTIR DE UN BENCENO 1,2,3-TRISUSTITUIDO PREPARADO POR ORTOLITIACION DE UN BENCENO 1,3-DISUSTITUIDO. EL BENCENO DIPROTEGIDO LITIADO SE TRATA DESPUES CON UN REACTIVO ELECTROFILO (PREFERIBLEMENTE CLOROFORMIATO DE ETILO), PARA INTRODUCIR EL SUSTITUYENTE ORTO DESEADO, Y FORMAR EL DERIVADO TRISUSTITUIDO (1,2,3). LA FUNCION HIDROXILO ES DESPROTEGIDA POR CALENTAMIENTO A REFLUJO CON P-TOLUENSULFONATO DE PIRIDINIO (PPTS), DESPUES SE REALIZA LA CONDENSACION DEL SALICILALDEHIDO LIBRE CON UNA ENAMINA PARA FORMAR LA 5-AMINOCROMONA PROTEGIDA. LAS CROMONAS Y TIOCROMONAS 5-SUSTITUIDAS Y SUS SALES POSEEN PROPIEDADES ANTIALERGICAS.
ES543515A 1984-05-29 1985-05-27 Un metodo para preparar una cromona-5 sustituida. Expired ES8700247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/615,042 US4571405A (en) 1984-05-29 1984-05-29 Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor

Publications (2)

Publication Number Publication Date
ES543515A0 ES543515A0 (es) 1986-09-16
ES8700247A1 true ES8700247A1 (es) 1986-09-16

Family

ID=24463776

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543515A Expired ES8700247A1 (es) 1984-05-29 1985-05-27 Un metodo para preparar una cromona-5 sustituida.
ES552106A Expired ES8704160A1 (es) 1984-05-29 1986-02-17 Un metodo para preparar una cromona 5-sustituida

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552106A Expired ES8704160A1 (es) 1984-05-29 1986-02-17 Un metodo para preparar una cromona 5-sustituida

Country Status (12)

Country Link
US (1) US4571405A (es)
EP (1) EP0163227B1 (es)
JP (2) JPS6178A (es)
AT (1) ATE45154T1 (es)
AU (2) AU555549B2 (es)
CA (1) CA1244453A (es)
DE (1) DE3571983D1 (es)
DK (1) DK234685A (es)
ES (2) ES8700247A1 (es)
FI (1) FI852102L (es)
NO (1) NO852023L (es)
ZA (1) ZA853257B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4571405A (en) * 1984-05-29 1986-02-18 Miles Laboratories, Inc. Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor
WO1999046268A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
CN107501142B (zh) * 2017-08-29 2019-11-08 厦门大学 还原响应型含双二硫键的化学连接物及其制备与用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU75688A1 (es) * 1976-08-31 1978-04-13
US4221800A (en) * 1977-12-23 1980-09-09 Miles Laboratories, Inc. Cycloalkenochromone
JPS5562082A (en) * 1978-11-01 1980-05-10 Kowa Co Tetrahydroxanthone derivative
DE2963792D1 (en) * 1978-12-22 1982-11-11 Sandoz Ag Indanyloxamic derivatives, their preparation and pharmaceutical compositions containing them
US4571405A (en) * 1984-05-29 1986-02-18 Miles Laboratories, Inc. Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor
DE3668450D1 (de) * 1985-03-14 1990-03-01 Smithkline Dauelsberg 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren.
US4731480A (en) * 1985-07-29 1988-03-15 Ortho Pharmaceutical Corporation Process for preparing 2-acyl-3,4-dialkoxyanilines

Also Published As

Publication number Publication date
FI852102A0 (fi) 1985-05-27
JPH0344063B2 (es) 1991-07-04
US4571405A (en) 1986-02-18
EP0163227B1 (en) 1989-08-02
ES543515A0 (es) 1986-09-16
AU555549B2 (en) 1986-10-02
DK234685A (da) 1985-11-30
AU4307285A (en) 1985-12-05
AU599327B2 (en) 1990-07-19
DK234685D0 (da) 1985-05-24
NO852023L (no) 1985-12-02
JPS62252753A (ja) 1987-11-04
ATE45154T1 (de) 1989-08-15
FI852102L (fi) 1985-11-30
AU6176586A (en) 1986-12-18
ES8704160A1 (es) 1987-03-16
JPS6352029B2 (es) 1988-10-17
ZA853257B (en) 1985-12-24
DE3571983D1 (en) 1989-09-07
EP0163227A1 (en) 1985-12-04
JPS6178A (ja) 1986-01-06
CA1244453A (en) 1988-11-08
ES552106A0 (es) 1987-03-16

Similar Documents

Publication Publication Date Title
TW262474B (es)
ES8603242A1 (es) Procedimiento para la obtencion de un derivado de nitrometi-leno
IE820753L (en) Acyl dipeptides
CA2334342A1 (en) Epothilone derivatives and their synthesis and use
FI864527A (fi) Tricyklofoereningar, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandning.
UA39869C2 (uk) Похідні аспартаму або їх фізіологічно прийнятні солі, спосіб їх отримання та підсолоджувальна композиція
AU8528291A (en) Leukotriene b4 antagonists
ES8605506A1 (es) Procedimiento para preparar derivados de piperidina
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
ES8703869A1 (es) Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona.
ES8704160A1 (es) Un metodo para preparar una cromona 5-sustituida
AU550340B2 (en) Dibenzazepine derivatives
EP0335979A4 (en) Thienopyrimidine derivatives
NZ201643A (en) 1,5-diphenylpyrazolin-3-ones and pharmaceutical compositions
ZA925093B (en) 6-oxo-azepinoindol compounds as well as a process and intermediate products for the production thereof,and drugs that contain these compounds
NZ335318A (en) (o-acyl-p-N-acylamino-phenyl)-O-phosphoethanolamines with anti-inflammatory activity
DE69111311T2 (de) 2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung.
JPS5615273A (en) Preparation of pyrimidine derivative