ES8608511A1 - Procedimiento para la preparacion de fenilpiperacinil-propa-noles substituidos - Google Patents

Procedimiento para la preparacion de fenilpiperacinil-propa-noles substituidos

Info

Publication number
ES8608511A1
ES8608511A1 ES544854A ES544854A ES8608511A1 ES 8608511 A1 ES8608511 A1 ES 8608511A1 ES 544854 A ES544854 A ES 544854A ES 544854 A ES544854 A ES 544854A ES 8608511 A1 ES8608511 A1 ES 8608511A1
Authority
ES
Spain
Prior art keywords
group
propanols
compounds
preparation
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544854A
Other languages
English (en)
Other versions
ES544854A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of ES8608511A1 publication Critical patent/ES8608511A1/es
Publication of ES544854A0 publication Critical patent/ES544854A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR FENILPIPERACINIL-PROPANOLES SUSTITUIDOS. COMPRENDE: A) HACER REACCIONAR A ARILCETONAS D.F. (III) CON DIMETILFORMAMIDODIMETILACETAL, EN ETANOL Y ENTRE 50 Y 100JC, PARA PRODUCIR UN C.D.F. (II); Y B) TRATAR A (II) CON CIANOACETAMIDA EN METANOL O ACETONITRILO, EN PRESENCIA DE UN CARBONATO ALCALINO Y ENTRE LA AMBIENTE Y 150JC Y DURANTE 8 A 72 HORAS, PARA OBTENER UN C.D.F. (I), SUS FORMAS TAUTOMERAS, SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES Y SUS N-OXIDOS. SIENDO: R1, H O ALQUILO DE C 1 A 4; R2 Y R3, H, HAL, CIANO Y OTROS; D.F., DE FORMULA; Y C.D.F., COMPUESTO D.F. SE UTILIZAN COMO VASODILATADORES BRONCOLITICOS PARA EL TRATAMIENTO DEL ASMA Y LA TROMBOSIS.
ES544854A 1984-07-05 1985-07-04 Procedimiento para la preparacion de fenilpiperacinil-propa-noles substituidos Expired ES8608511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843424685 DE3424685A1 (de) 1984-07-05 1984-07-05 Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen

Publications (2)

Publication Number Publication Date
ES8608511A1 true ES8608511A1 (es) 1986-07-16
ES544854A0 ES544854A0 (es) 1986-07-16

Family

ID=6239858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544854A Expired ES8608511A1 (es) 1984-07-05 1985-07-04 Procedimiento para la preparacion de fenilpiperacinil-propa-noles substituidos

Country Status (9)

Country Link
US (1) US4631281A (es)
EP (1) EP0167121B1 (es)
JP (1) JPS6130573A (es)
AT (1) ATE68788T1 (es)
AU (1) AU571821B2 (es)
CA (1) CA1241959A (es)
DE (2) DE3424685A1 (es)
ES (1) ES8608511A1 (es)
ZA (1) ZA854837B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051431A (en) * 1989-09-22 1991-09-24 Glaxo Inc. Pyridone nitriles useful in treating cardiovascular disease
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
NZ717739A (en) 2013-08-09 2023-12-22 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2263211A1 (de) * 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim Neue arylpiperazine und verfahren zu ihrer herstellung
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
DE2824677A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
DE2834114A1 (de) * 1978-08-01 1980-02-14 Schering Ag Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3226863A1 (de) * 1981-09-18 1983-04-07 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
JPS58164583A (ja) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd フエノキシプロパノ−ルアミン誘導体
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤

Also Published As

Publication number Publication date
DE3584478D1 (de) 1991-11-28
ATE68788T1 (de) 1991-11-15
JPS6130573A (ja) 1986-02-12
AU4447485A (en) 1986-01-09
EP0167121A3 (en) 1988-08-17
EP0167121A2 (de) 1986-01-08
ZA854837B (en) 1986-02-26
DE3424685A1 (de) 1986-02-06
AU571821B2 (en) 1988-04-21
US4631281A (en) 1986-12-23
ES544854A0 (es) 1986-07-16
JPH0473432B2 (es) 1992-11-20
CA1241959A (en) 1988-09-13
EP0167121B1 (de) 1991-10-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030503