ES8506714A1 - Triazol (2,3-c)pirimidin-aminas(-amidas) - Google Patents
Triazol (2,3-c)pirimidin-aminas(-amidas)Info
- Publication number
- ES8506714A1 ES8506714A1 ES533537A ES533537A ES8506714A1 ES 8506714 A1 ES8506714 A1 ES 8506714A1 ES 533537 A ES533537 A ES 533537A ES 533537 A ES533537 A ES 533537A ES 8506714 A1 ES8506714 A1 ES 8506714A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- amines
- triazolo
- pyrimidines
- amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE TRIAZOL 2,3-C PIRIMIDIN-AMINAS(-AMIDAS), DE FORMULA GENERAL (I), EN LA QUE R1 ES HIDROGENO, HALOGENO O ALCOXI; R2 Y R3 SON HIDROGENO, ALCANOILO O ALQUILO DE 1 A 6 ATOMOS DE CARBONO; Y R4 ES ALCONOILOXIALQUILO O BENZOILOXIALQUILO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE Y ES HIDROXI, ETOXI O BROMO, CON UN REACTIVO ADECUADO SELECCIONADO ENTRE TRICLORURO DE BORO, TRIBROMURO DE BORO Y ANHIDRIDO SUCCINICO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (II), Y EN TRATAR DICHOS COMPUESTOS DE FORMULA GENERAL (II) CON IODOMETANO.DE APLICACION COMO DIURETICOS FARMACEUTICOS USADOS PARA INCREMENTAR EL VOLUMEN DE ORINA EXCRETADA POR LOS RIN/ONES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/506,157 US4483987A (en) | 1983-06-20 | 1983-06-20 | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8506714A1 true ES8506714A1 (es) | 1985-08-01 |
ES533537A0 ES533537A0 (es) | 1985-08-01 |
Family
ID=24013440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533537A Granted ES533537A0 (es) | 1983-06-20 | 1984-06-19 | Triazol (2,3-c)pirimidin-aminas(-amidas) |
Country Status (7)
Country | Link |
---|---|
US (1) | US4483987A (es) |
EP (1) | EP0129247A1 (es) |
JP (1) | JPS6013792A (es) |
AU (1) | AU566670B2 (es) |
CA (1) | CA1204741A (es) |
ES (1) | ES533537A0 (es) |
ZA (1) | ZA844669B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3130633A1 (de) * | 1981-08-01 | 1983-02-17 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)pyrimidine und diese enthaltende fungizide |
US4562192A (en) * | 1984-02-03 | 1985-12-31 | G. D. Searle & Co. | 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them |
JPS62107954A (ja) * | 1985-11-05 | 1987-05-19 | Tomiji Saito | 可塑性研磨材料 |
EP0244948A3 (en) * | 1986-04-30 | 1989-03-15 | Schering Agrochemicals Limited | Triazolopyrimidine herbicides |
JPH07115284B2 (ja) * | 1986-07-18 | 1995-12-13 | 株式会社東芝 | 非球面部材のみがき装置 |
US5338743A (en) * | 1988-06-06 | 1994-08-16 | Fujisawa Pharmaceutical Co., Ltd. | New use of the adenosine antagonist |
US4866063A (en) * | 1988-12-22 | 1989-09-12 | G. D. Searle & Co. | Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines |
FR2687676B1 (fr) * | 1992-02-24 | 1994-07-08 | Union Pharma Scient Appl | Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
AU743910B2 (en) | 1997-03-24 | 2002-02-07 | Kyowa Hakko Kirin Co., Ltd. | {1,2,4}triazolo{1,5-c}pyrimidine derivatives |
CN1328560A (zh) | 1998-09-22 | 2001-12-26 | 协和发酵工业株式会社 | [1,2,4]三唑并[1,5-c]嘧啶衍生物 |
JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
US6998148B1 (en) | 2001-03-28 | 2006-02-14 | Shipley Company, L.L.C. | Porous materials |
JP2005509495A (ja) * | 2001-11-16 | 2005-04-14 | チルドレンズ メディカル センター コーポレーション | 臓器の機能の増強 |
JPWO2004029056A1 (ja) * | 2002-09-24 | 2006-01-26 | 協和醗酵工業株式会社 | [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体 |
EP3883576A4 (en) * | 2018-11-20 | 2022-06-22 | Merck Sharp & Dohme Corp. | SUBSTITUTED AMINOTRIAZOLOPYRIMIDINES AND AMINO-TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3053844A (en) * | 1959-04-13 | 1962-09-11 | Ici Ltd | Mono-acyl derivatives of s-triazolo [2, 3-c] pyrimidines |
US3046276A (en) * | 1959-06-15 | 1962-07-24 | Ici Ltd | S-triazolo-[2, 3-c] pyrimidine derivatives |
US4205169A (en) * | 1979-04-09 | 1980-05-27 | G. D. Searle & Co. | N-[4-Azido-5-(2-ethoxyethyl)-6-phenyl-2-pyrimidinyl]acetamide and congeners |
US4405780A (en) * | 1979-08-08 | 1983-09-20 | G. D. Searle & Co. | 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides |
GB2056449A (en) * | 1979-08-08 | 1981-03-18 | Searle & Co | 8-substituted-7-phenyl-1,2,4- triazolo[4,3-c] pyrimidine-5-amines and amides |
US4269980A (en) * | 1979-12-17 | 1981-05-26 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines |
-
1983
- 1983-06-20 US US06/506,157 patent/US4483987A/en not_active Expired - Fee Related
-
1984
- 1984-06-19 CA CA000456918A patent/CA1204741A/en not_active Expired
- 1984-06-19 EP EP84107022A patent/EP0129247A1/en not_active Withdrawn
- 1984-06-19 AU AU29494/84A patent/AU566670B2/en not_active Ceased
- 1984-06-19 ES ES533537A patent/ES533537A0/es active Granted
- 1984-06-20 JP JP59127266A patent/JPS6013792A/ja active Granted
- 1984-06-20 ZA ZA844669A patent/ZA844669B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0129247A1 (en) | 1984-12-27 |
AU566670B2 (en) | 1987-10-29 |
JPH0471074B2 (es) | 1992-11-12 |
US4483987A (en) | 1984-11-20 |
CA1204741A (en) | 1986-05-20 |
JPS6013792A (ja) | 1985-01-24 |
ES533537A0 (es) | 1985-08-01 |
ZA844669B (en) | 1985-08-28 |
AU2949484A (en) | 1985-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970505 |