ES8607922A1 - Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatos - Google Patents
Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatosInfo
- Publication number
- ES8607922A1 ES8607922A1 ES545701A ES545701A ES8607922A1 ES 8607922 A1 ES8607922 A1 ES 8607922A1 ES 545701 A ES545701 A ES 545701A ES 545701 A ES545701 A ES 545701A ES 8607922 A1 ES8607922 A1 ES 8607922A1
- Authority
- ES
- Spain
- Prior art keywords
- phenoxy
- alpha
- trienoates
- tetranorprosta
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000951 phenoxy group Chemical class [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 9-OXO-15A-HIDROXI-16-FENOXI Y 16-FENOXI SUSTITUIDO-17,18,19,20-TETRANOPROSTA-4,5,13(E)-TRIENOATOS, DE FORMULA (I), DE SU CONTRAPARTIDA DE LA CONFIGURACION DE PROSTAGLANDINA NO NATURAL Y SUS MEZCLAS Y SALES NO TOXICAS FISIOLOGICAMENTE COMPATIBLES, FORMULA EN LA QUE R ES HIDROGENO O ALQUILO Y X PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE HIDROLISIS DEL GRUPO RL DE UN COMPUESTO DE FORMULA (II) O SU CONTRAPARTIDA DE LA CONFIGURACION DE PROSTAGLANDINA NO NATURAL O DE SUS MEZCLAS, EN LA QUE RL ES UN GRUPO FORMADOR DE ETER Y R Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA HIDROLISIS SE EFECTUA POR TRATAMIENTO CON UN ACIDO ALCANOICO EN UN DISOLVENTE ORGANICO A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 60JC, O CON DISOLUCION DE HALURO DE HIDROGENO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/636,058 US4618696A (en) | 1984-07-31 | 1984-07-31 | 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545701A0 ES545701A0 (es) | 1986-06-16 |
| ES8607922A1 true ES8607922A1 (es) | 1986-06-16 |
Family
ID=24550237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545701A Expired ES8607922A1 (es) | 1984-07-31 | 1985-07-30 | Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4618696A (es) |
| EP (1) | EP0170260A3 (es) |
| JP (1) | JPS6143161A (es) |
| AU (1) | AU574211B2 (es) |
| DK (1) | DK345985A (es) |
| ES (1) | ES8607922A1 (es) |
| HU (1) | HU196747B (es) |
| NZ (1) | NZ212915A (es) |
| ZA (1) | ZA855741B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4600785A (en) * | 1983-12-22 | 1986-07-15 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| US4912235A (en) * | 1983-12-22 | 1990-03-27 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers |
| US4804787A (en) * | 1983-12-22 | 1989-02-14 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| DK346085A (da) * | 1984-07-31 | 1986-02-01 | Syntex Inc | Prostatriensyrederivater |
| DK606185A (da) * | 1984-12-24 | 1986-06-25 | Syntex Inc | Prostaglandinderivater |
| JPS63178105U (es) * | 1987-01-29 | 1988-11-17 | ||
| DE10130449A1 (de) * | 2001-06-23 | 2003-01-09 | Martin Schmidt | Inhalierbare Sedativa und Hypnotika für den medizinischen Gebrauch |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178457A (en) * | 1978-07-10 | 1979-12-11 | Syntex (U.S.A.) Inc. | (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof |
| DK346085A (da) * | 1984-07-31 | 1986-02-01 | Syntex Inc | Prostatriensyrederivater |
-
1984
- 1984-07-31 US US06/636,058 patent/US4618696A/en not_active Expired - Fee Related
-
1985
- 1985-07-30 DK DK345985A patent/DK345985A/da not_active Application Discontinuation
- 1985-07-30 ES ES545701A patent/ES8607922A1/es not_active Expired
- 1985-07-30 AU AU45621/85A patent/AU574211B2/en not_active Ceased
- 1985-07-30 EP EP85109583A patent/EP0170260A3/en not_active Ceased
- 1985-07-30 ZA ZA855741A patent/ZA855741B/xx unknown
- 1985-07-30 JP JP60169654A patent/JPS6143161A/ja active Pending
- 1985-07-30 NZ NZ212915A patent/NZ212915A/xx unknown
- 1985-07-30 HU HU852916A patent/HU196747B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU574211B2 (en) | 1988-06-30 |
| ES545701A0 (es) | 1986-06-16 |
| EP0170260A2 (en) | 1986-02-05 |
| HUT38308A (en) | 1986-05-28 |
| DK345985A (da) | 1986-02-01 |
| NZ212915A (en) | 1988-08-30 |
| HU196747B (en) | 1989-01-30 |
| EP0170260A3 (en) | 1986-09-10 |
| AU4562185A (en) | 1986-02-06 |
| DK345985D0 (da) | 1985-07-30 |
| JPS6143161A (ja) | 1986-03-01 |
| US4618696A (en) | 1986-10-21 |
| ZA855741B (en) | 1987-03-25 |
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