ES8607236A1 - Procedimiento para la obtencion de la sal de etanolamina de 6-cicloexil-1-hidroxi-4-metil-2(1h)-piridona. - Google Patents
Procedimiento para la obtencion de la sal de etanolamina de 6-cicloexil-1-hidroxi-4-metil-2(1h)-piridona.Info
- Publication number
- ES8607236A1 ES8607236A1 ES544827A ES544827A ES8607236A1 ES 8607236 A1 ES8607236 A1 ES 8607236A1 ES 544827 A ES544827 A ES 544827A ES 544827 A ES544827 A ES 544827A ES 8607236 A1 ES8607236 A1 ES 8607236A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridone
- cyclohexyl
- methyl
- cyclo
- ethanolamine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002169 ethanolamines Chemical class 0.000 title abstract 2
- -1 hexyl hydroxy methyl pyridone Chemical compound 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 abstract 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
- GNHZWBVSGWJMLC-UHFFFAOYSA-N 2-chloro-6-cyclohexyl-4-methylpyridine Chemical compound CC1=CC(Cl)=NC(C2CCCCC2)=C1 GNHZWBVSGWJMLC-UHFFFAOYSA-N 0.000 abstract 1
- 239000007832 Na2SO4 Substances 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- DLGYNVMUCSTYDQ-UHFFFAOYSA-N azane;pyridine Chemical compound N.C1=CC=NC=C1 DLGYNVMUCSTYDQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 235000010288 sodium nitrite Nutrition 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
METODO DE OBTENCION DE LA SAL DE ETANOLAMINA DE 6-CICLOHEXIL-1-HIDROXI-4-METIL-2(1H)-PIRIDONA. SE LLEVA A CABO POR REACCION DE 2-CICLOHEXIL-4-METIL-6-CLOROPIRIDINA CON AMONIACO ANHIDRO; A PRESION ELEVADA; OBTENIENDOSE 2-CICLOHEXIL-4-METIL-6-AMINOPIRIDINA; QUE POR TRATAMIENTO CON ACIDO PERACETICO EN ACIDO ACETICO COMO DISOLVENTE SE PRODUCE LA OXIDACION DEL NITROGENO PIRIDINICO. POSTERIORMENTE Y PREVIA NEUTRALIZACION DEL ACIDO, MEDIANTE BICARBONATO SODICO, EN MEDIO ACUOSO SE EXTRAE EL PRODUCTO OBTENIDO. SE CONCENTRA A SEQUEDAD EL PRODUCTO;, Y SE TRATA CON NITRITO SODICO PARA DIAZOTACION, EN SOLUCION ACUOSA A BAJA TEMPERATURA. EL MEDIO DE REACCION SE VIERTE SOBRE UNA MEZCLA DE ACIDO SULFURICO-AGUA CALIENTE, OBTENIENDOSE 6-CICLOHEXIL-1-HIDROXI-4-METIL-2(1)PIRIDONA, QUE PRECIPITA A PH NEUTRO. EL COMPUESTO RESULTANTE SE DISUELVE EN ETER SULFURICO, PARA DESHIDRATACION CON SULFATO SODICO ANHIDRO. POR ULTIMO SE SALIFICA CON ETANOLAMINA Y EL DISOLVENTE SE EVAPOR RESULTADO EL PRODUCTO DESEADO. DE UTILIZACION FAMACOLOGICA POR SU ACTIVIDAD ANTIFUNGICA, FRENTE A UN AMPLIO ESPECTRO DE DERMATOFITOS Y LEVADURAS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES544827A ES8607236A1 (es) | 1985-07-03 | 1985-07-03 | Procedimiento para la obtencion de la sal de etanolamina de 6-cicloexil-1-hidroxi-4-metil-2(1h)-piridona. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES544827A ES8607236A1 (es) | 1985-07-03 | 1985-07-03 | Procedimiento para la obtencion de la sal de etanolamina de 6-cicloexil-1-hidroxi-4-metil-2(1h)-piridona. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607236A1 true ES8607236A1 (es) | 1986-06-01 |
| ES544827A0 ES544827A0 (es) | 1986-06-01 |
Family
ID=8489465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544827A Expired ES8607236A1 (es) | 1985-07-03 | 1985-07-03 | Procedimiento para la obtencion de la sal de etanolamina de 6-cicloexil-1-hidroxi-4-metil-2(1h)-piridona. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8607236A1 (es) |
-
1985
- 1985-07-03 ES ES544827A patent/ES8607236A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES544827A0 (es) | 1986-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960401 |