JPS5531005A - Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' - Google Patents

Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2'

Info

Publication number
JPS5531005A
JPS5531005A JP10273378A JP10273378A JPS5531005A JP S5531005 A JPS5531005 A JP S5531005A JP 10273378 A JP10273378 A JP 10273378A JP 10273378 A JP10273378 A JP 10273378A JP S5531005 A JPS5531005 A JP S5531005A
Authority
JP
Japan
Prior art keywords
potassium
sodium
ferricyanide
cotinine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10273378A
Other languages
Japanese (ja)
Other versions
JPS566424B2 (en
Inventor
Yasuko Tsujino
Masao Noguchi
Takuro Kisaki
Kunio Kato
Hajime Matsushita
Akira Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Japan Tobacco and Salt Public Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc, Japan Tobacco and Salt Public Corp filed Critical Japan Tobacco Inc
Priority to JP10273378A priority Critical patent/JPS5531005A/en
Publication of JPS5531005A publication Critical patent/JPS5531005A/en
Publication of JPS566424B2 publication Critical patent/JPS566424B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Manufacture Of Tobacco Products (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: To obtain high-purity cotinine useful as an intermediate for a flavor improver of tobacco, medical supplies and agricultural medicines industrially, advantageously by the direct oxidation of nicotine with an aqueous solution of sodium (potassium) ferricyanide usalbe repeatedly and an alkali.
CONSTITUTION: 2'-(3-Pyridyl)-N'-methyl pyrrolidine(nicotine) is directly oxidized with an aqueous solution of potassium or sodium ferricyanide and an alkali, at 0W50°C to give 5'-(3-pyridyl)-N'-methyl pyrrolidone-2' (the common name is cotinine). The sodium (potassium) ferricyanide consumed in the reaction leads to sodium (potassium) ferrocyanide, which can be recovered as sodium (potassium) ferricyanide and reused, by blowing chlorine into the reaction mixture after the cotinine is extracted. This method is suitable for industrial massproduction.
COPYRIGHT: (C)1980,JPO&Japio
JP10273378A 1978-08-25 1978-08-25 Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' Granted JPS5531005A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10273378A JPS5531005A (en) 1978-08-25 1978-08-25 Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2'

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10273378A JPS5531005A (en) 1978-08-25 1978-08-25 Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2'

Publications (2)

Publication Number Publication Date
JPS5531005A true JPS5531005A (en) 1980-03-05
JPS566424B2 JPS566424B2 (en) 1981-02-10

Family

ID=14335439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10273378A Granted JPS5531005A (en) 1978-08-25 1978-08-25 Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2'

Country Status (1)

Country Link
JP (1) JPS5531005A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027303A1 (en) * 1995-03-06 1996-09-12 Lectec Corporation Nicotine-free smoking material
WO2022264621A1 (en) * 2021-06-15 2022-12-22 日本たばこ産業株式会社 Composition for tobacco

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60180423U (en) * 1984-05-10 1985-11-30 松下電工株式会社 Facial massager

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027303A1 (en) * 1995-03-06 1996-09-12 Lectec Corporation Nicotine-free smoking material
US5880164A (en) * 1995-03-06 1999-03-09 Lectec Corporation Nicotine-free smoking material
WO2022264621A1 (en) * 2021-06-15 2022-12-22 日本たばこ産業株式会社 Composition for tobacco

Also Published As

Publication number Publication date
JPS566424B2 (en) 1981-02-10

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