JPS5531005A - Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' - Google Patents
Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2'Info
- Publication number
- JPS5531005A JPS5531005A JP10273378A JP10273378A JPS5531005A JP S5531005 A JPS5531005 A JP S5531005A JP 10273378 A JP10273378 A JP 10273378A JP 10273378 A JP10273378 A JP 10273378A JP S5531005 A JPS5531005 A JP S5531005A
- Authority
- JP
- Japan
- Prior art keywords
- potassium
- sodium
- ferricyanide
- cotinine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Manufacture Of Tobacco Products (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To obtain high-purity cotinine useful as an intermediate for a flavor improver of tobacco, medical supplies and agricultural medicines industrially, advantageously by the direct oxidation of nicotine with an aqueous solution of sodium (potassium) ferricyanide usalbe repeatedly and an alkali.
CONSTITUTION: 2'-(3-Pyridyl)-N'-methyl pyrrolidine(nicotine) is directly oxidized with an aqueous solution of potassium or sodium ferricyanide and an alkali, at 0W50°C to give 5'-(3-pyridyl)-N'-methyl pyrrolidone-2' (the common name is cotinine). The sodium (potassium) ferricyanide consumed in the reaction leads to sodium (potassium) ferrocyanide, which can be recovered as sodium (potassium) ferricyanide and reused, by blowing chlorine into the reaction mixture after the cotinine is extracted. This method is suitable for industrial massproduction.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10273378A JPS5531005A (en) | 1978-08-25 | 1978-08-25 | Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10273378A JPS5531005A (en) | 1978-08-25 | 1978-08-25 | Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5531005A true JPS5531005A (en) | 1980-03-05 |
JPS566424B2 JPS566424B2 (en) | 1981-02-10 |
Family
ID=14335439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10273378A Granted JPS5531005A (en) | 1978-08-25 | 1978-08-25 | Preparation of 5'-(3-pyrydyl)-n'-methyl-pyrrolidone-2' |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5531005A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027303A1 (en) * | 1995-03-06 | 1996-09-12 | Lectec Corporation | Nicotine-free smoking material |
WO2022264621A1 (en) * | 2021-06-15 | 2022-12-22 | 日本たばこ産業株式会社 | Composition for tobacco |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60180423U (en) * | 1984-05-10 | 1985-11-30 | 松下電工株式会社 | Facial massager |
-
1978
- 1978-08-25 JP JP10273378A patent/JPS5531005A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027303A1 (en) * | 1995-03-06 | 1996-09-12 | Lectec Corporation | Nicotine-free smoking material |
US5880164A (en) * | 1995-03-06 | 1999-03-09 | Lectec Corporation | Nicotine-free smoking material |
WO2022264621A1 (en) * | 2021-06-15 | 2022-12-22 | 日本たばこ産業株式会社 | Composition for tobacco |
Also Published As
Publication number | Publication date |
---|---|
JPS566424B2 (en) | 1981-02-10 |
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