ES8606318A1 - Un procedimiento para la preparacion de nuevos tetrahidrofuranos y analogos de los mismos. - Google Patents

Un procedimiento para la preparacion de nuevos tetrahidrofuranos y analogos de los mismos.

Info

Publication number
ES8606318A1
ES8606318A1 ES537583A ES537583A ES8606318A1 ES 8606318 A1 ES8606318 A1 ES 8606318A1 ES 537583 A ES537583 A ES 537583A ES 537583 A ES537583 A ES 537583A ES 8606318 A1 ES8606318 A1 ES 8606318A1
Authority
ES
Spain
Prior art keywords
formula
analogs
paf
antagonists
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537583A
Other languages
English (en)
Other versions
ES537583A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES537583A0 publication Critical patent/ES537583A0/es
Publication of ES8606318A1 publication Critical patent/ES8606318A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE TETRAHIDROFURANOS Y ANALOGOS DE LOS MISMOS, DE FORMULA (I), EN LA QUE R, R1, AR Y AR1 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE REDUCCION DE UNA 1,4-DIARIL-1,4-DICETONA, DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR TRATAMIENTO CON HIDROGENO EN PRESENCIA DE UN CATALIZADOR O CON AGENTES REDUCTORES DE HIDRURO METALICO, A UNA TEMPERATURA COMPRENDIDA ENTRE C30JC Y 100JC; SEGUIDA DE LA CICLACION DEL 1,4-DIOL FORMADO POR AGITACION O CALENTAMIENTO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFLAMACION, TRASTORNOS CARDIOVASCULARES, ASMA, EDEMA PULMONAR Y AGREGACION DE PLAQUETAS.
ES537583A 1983-11-14 1984-11-12 Un procedimiento para la preparacion de nuevos tetrahidrofuranos y analogos de los mismos. Expired ES8606318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/551,666 US4539332A (en) 1983-11-14 1983-11-14 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists

Publications (2)

Publication Number Publication Date
ES537583A0 ES537583A0 (es) 1986-04-16
ES8606318A1 true ES8606318A1 (es) 1986-04-16

Family

ID=24202197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537583A Expired ES8606318A1 (es) 1983-11-14 1984-11-12 Un procedimiento para la preparacion de nuevos tetrahidrofuranos y analogos de los mismos.

Country Status (8)

Country Link
US (1) US4539332A (es)
EP (1) EP0144804B1 (es)
JP (1) JPS60116679A (es)
AT (1) ATE50768T1 (es)
CA (1) CA1267417A (es)
DE (1) DE3481511D1 (es)
DK (1) DK538384A (es)
ES (1) ES8606318A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619943A (en) * 1981-06-04 1986-10-28 Rao Koppaka V Neolignans of Saururus cernuus L and analogues thereof
US5010100A (en) * 1983-11-14 1991-04-23 Merck & Co. Inc. Certain 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
JPS61212518A (ja) * 1985-03-19 1986-09-20 Nippon Paint Co Ltd 血液凝固促進剤
NZ215866A (en) * 1985-04-22 1989-11-28 Merck & Co Inc 2,5-di(aryl/heterocyclyl) tetrahydro-furans and pharmaceutical compositions
EP0257921B1 (en) * 1986-08-21 1992-04-15 Merck & Co. Inc. New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists
US4879285A (en) * 1986-08-22 1989-11-07 Royal North Shore Hospital And Area Health Service Fertility control
PH23898A (en) * 1986-09-12 1989-12-18 Duphar Int Res New phenyl pyrrolidin-2-yl substituted-2-yl substituted 5-ring heterocycles having antipsycotic properties
GB2197650A (en) * 1986-11-21 1988-05-25 Merck & Co Inc Process for preparing 2,5-diphenyl tetrahydrofurans and analogs thereof
US4996203A (en) * 1987-12-21 1991-02-26 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
NZ227287A (en) * 1987-12-21 1992-01-29 Merck & Co Inc 2,5-diaryl tetrahydrofurans and medicaments
WO1989010143A1 (en) * 1988-04-27 1989-11-02 Schering Corporation Certain paf antagonist antihistamine combinations and methods
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
ES2010568A6 (es) * 1988-08-04 1989-11-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
US5114961A (en) * 1989-06-08 1992-05-19 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5001123A (en) * 1989-06-08 1991-03-19 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5011847A (en) * 1989-06-08 1991-04-30 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US4977146A (en) * 1989-06-08 1990-12-11 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
DE4014420A1 (de) * 1989-09-23 1991-04-04 Bayer Ag 5h-furan-2-on-derivate
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
US5099033A (en) * 1990-06-29 1992-03-24 Merck & Co., Inc. Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as PAF antagonists
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides
IE912874A1 (en) * 1990-08-15 1992-02-26 British Bio Technology Compounds
HUT65173A (en) * 1991-03-04 1994-05-02 Innovative Tech Center Neolignan derivatives and pharmaceutical preparations containing them
GB9104746D0 (en) * 1991-03-06 1991-04-17 British Bio Technology Compounds
GB9114337D0 (en) * 1991-07-03 1991-08-21 British Bio Technology Compounds
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
GB9200209D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
DE69329550T2 (de) 1992-07-13 2001-05-31 Cytomed Inc 2,5-diaryl tetrahydro-thiopene, -furane und analoge zur behandlung von entzündungs-und immunkrankheiten
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1994015594A1 (en) * 1993-01-11 1994-07-21 Tsumura & Co. Vascularization inhibitor and novel compound
US6492413B2 (en) * 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US20240065809A1 (en) 2020-12-30 2024-02-29 3M Innovative Properties Company Bondable orthodontic assemblies and methods for bonding

Also Published As

Publication number Publication date
ES537583A0 (es) 1986-04-16
EP0144804A3 (en) 1986-01-08
EP0144804B1 (en) 1990-03-07
JPS60116679A (ja) 1985-06-24
US4539332A (en) 1985-09-03
DK538384D0 (da) 1984-11-13
DK538384A (da) 1985-06-19
ATE50768T1 (de) 1990-03-15
JPH0550516B2 (es) 1993-07-29
CA1267417A (en) 1990-04-03
DE3481511D1 (de) 1990-04-12
EP0144804A2 (en) 1985-06-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506