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Dr Andreu SA
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Dr Andreu SA
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Priority to ES540352ApriorityCriticalpatent/ES8605253A1/en
Publication of ES540352A0publicationCriticalpatent/ES540352A0/en
Publication of ES8605253A1publicationCriticalpatent/ES8605253A1/en
Guanidino-thiazole derivs. of formula (I), in which R1 is H or lower alkyl, R2 can be various radicals, and m and n are 1-5, and their acceptable acid addn. salts are made by reaction of a cpd of formula (II) with a cpd. of formula (III), in which A is SH, Cl, Br or I, B has the same significance as, but is not identical to A. Reaction is carried out in methanol or ethanol in presence of sodium ethoxide, at -10 to 78 deg.C.