ES8605156A1 - Un metodo para la preparacion de un conjugado inmunogeno de un hapteno con un portador, util para la produccion de anticuerpos. - Google Patents

Un metodo para la preparacion de un conjugado inmunogeno de un hapteno con un portador, util para la produccion de anticuerpos.

Info

Publication number
ES8605156A1
ES8605156A1 ES530899A ES530899A ES8605156A1 ES 8605156 A1 ES8605156 A1 ES 8605156A1 ES 530899 A ES530899 A ES 530899A ES 530899 A ES530899 A ES 530899A ES 8605156 A1 ES8605156 A1 ES 8605156A1
Authority
ES
Spain
Prior art keywords
antibodies
urea
hapten
carrier
preparative method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530899A
Other languages
English (en)
Other versions
ES530899A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of ES8605156A1 publication Critical patent/ES8605156A1/es
Publication of ES530899A0 publication Critical patent/ES530899A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

METODO PARA LA PREPARACION DE UN CONJUGADO INMUNOGENO DE UN HAPTENO CON UN PORTADOR. CONSISTE EN HACER REACCIONAR UN HAPTENO CON UN CARBONIL-DIIMIFDAZOL, Y DESPUES PONER EN CONTACTO EL HAPTENO ACTIVADO RESULTANTE CON UNA PROTEINA O POLIPEPTIDO INMUNOGENICO, PARA OBTENER UN CONJUGADO INMUNOGENO DE HAPTENO DEFORMULA (I); DONDE HAPTENO REPRESENTA EL HAPTENO ACOPLADO A TRAVES DE UN GRUPO AMINO, (NH)PORTADOR REPRESENTA UNA PROTEINA O POLIPEPTIDO INMUNOGENOS ACOPLADOS DIRECTAMENTE A TRAVES DE GRUPOS AMINO EN LOS MISMOS; Y P ES DE PROMEDIO ENTRE 1 Y EL NUMERO DE GRUPOS AMINO DISPONIBLES EN EL PORTADOR. TIENE APLICACIONES TERAPEUTICAS PARA LA PRODUCCION DE ANTICUERPOS.
ES530899A 1983-03-28 1984-03-23 Un metodo para la preparacion de un conjugado inmunogeno de un hapteno con un portador, util para la produccion de anticuerpos. Expired ES8605156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/479,757 US4486344A (en) 1983-03-28 1983-03-28 Urea-linked immunogens, antibodies, and preparative method

Publications (2)

Publication Number Publication Date
ES8605156A1 true ES8605156A1 (es) 1986-03-16
ES530899A0 ES530899A0 (es) 1986-03-16

Family

ID=23905299

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530899A Expired ES8605156A1 (es) 1983-03-28 1984-03-23 Un metodo para la preparacion de un conjugado inmunogeno de un hapteno con un portador, util para la produccion de anticuerpos.

Country Status (7)

Country Link
US (1) US4486344A (es)
EP (1) EP0123114A1 (es)
JP (1) JPS59206765A (es)
AU (1) AU546757B2 (es)
CA (1) CA1212900A (es)
ES (1) ES8605156A1 (es)
IL (1) IL70968A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650771A (en) * 1983-11-04 1987-03-17 Miles Laboratories, Inc. Immunogens, antibodies, labeled conjugates, and related derivatives for lidocaine and analogs thereof
US4670406A (en) * 1984-01-06 1987-06-02 Becton Dickinson And Company Tracers for use in assays
AU600432B2 (en) * 1984-11-27 1990-08-16 Dade Behring Marburg Gmbh Divalent hapten derivatives, process for preparing and use of them
US4762915A (en) * 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US4824659A (en) * 1985-06-07 1989-04-25 Immunomedics, Inc. Antibody conjugates
US5175697A (en) * 1986-06-02 1992-12-29 Minolta Camera Kabushiki Kaisha Spectrophotometer for accurately measuring light intensity in a specific wavelength region
FR2601141A1 (fr) * 1986-07-02 1988-01-08 Centre Nat Rech Scient Produit de couplage a base d'haptene, utile notamment comme substance immunogene, anticorps correspondants et applications
DE3727987A1 (de) * 1987-08-21 1989-03-02 Sleytr Uwe B Pharmazeutische struktur
JPH01165961A (ja) * 1987-12-22 1989-06-29 Baiteku Res:Kk ビリルビン抗原、そのモノクローナル抗体、それらの製造方法およびその用途
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
DE4447484C2 (de) * 1994-04-08 1997-07-17 Deutsches Krebsforsch Mittel zur Hemmung von Apoptose
DE4438660A1 (de) * 1994-10-28 1996-05-02 Boehringer Mannheim Gmbh Biolumineszenzmarkierte Hapten-Konjugate für den Einsatz in kompetitiven Immunoassays
US7011940B1 (en) 1999-04-14 2006-03-14 Medical Discovery Partners Llc Quality control for cytochemical assays
KR20080072686A (ko) * 2005-11-29 2008-08-06 말린크로트, 인코포레이티드 이관능성 금속 킬레이팅 컨쥬게이트
US20070141723A1 (en) * 2005-12-16 2007-06-21 Sompuram Seshi A Immunohistochemistry staining controls

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396316A (de) * 1960-07-12 1965-07-31 Wander Ag Dr A Verfahren zur Herstellung von Impfstoffen
SE337223B (es) * 1967-05-23 1971-08-02 Pharmacia Ab
JPS4941526A (es) * 1972-05-15 1974-04-18
US4041076A (en) * 1974-10-23 1977-08-09 Hoffmann-La Roche Inc. Immunoassay for pharmacologically active phenethylamines
JPS5366417A (en) * 1976-11-25 1978-06-13 Dainippon Pharmaceut Co Ltd Haptene antigens
DE2862449D1 (en) * 1977-08-22 1984-11-22 Nat Res Dev Macromolecular covalent conjugates, methods for preparing and pharmaceutical compositions containing them
US4192799A (en) * 1977-09-21 1980-03-11 The Upjohn Company Conjugates formed by reacting a prostaglandin mimic compound with a carrier molecule
US4218436A (en) * 1977-09-21 1980-08-19 The Upjohn Company Compounds and methods
US4276206A (en) * 1979-01-18 1981-06-30 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
IL65556A (en) * 1981-05-20 1985-07-31 Robins Co Inc A H Pharmaceutical compositions containing n-(aryloxyalkyl)-n'-(aminoalkyl)ureas or salts thereof and some such novel compounds
US4533493A (en) * 1981-08-27 1985-08-06 Miles Laboratories, Inc. Theophylline immunogens, antibodies, labeled conjugates, and related derivatives

Also Published As

Publication number Publication date
CA1212900A (en) 1986-10-21
AU2527284A (en) 1984-10-11
IL70968A (en) 1986-10-31
IL70968A0 (en) 1984-05-31
ES530899A0 (es) 1986-03-16
EP0123114A1 (en) 1984-10-31
JPS59206765A (ja) 1984-11-22
US4486344A (en) 1984-12-04
AU546757B2 (en) 1985-09-19

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