ES8604623A1 - Un procedimiento para la produccion de un complejo covalentemente enlazado de heparina-antitrombina-iii - Google Patents
Un procedimiento para la produccion de un complejo covalentemente enlazado de heparina-antitrombina-iiiInfo
- Publication number
- ES8604623A1 ES8604623A1 ES536055A ES536055A ES8604623A1 ES 8604623 A1 ES8604623 A1 ES 8604623A1 ES 536055 A ES536055 A ES 536055A ES 536055 A ES536055 A ES 536055A ES 8604623 A1 ES8604623 A1 ES 8604623A1
- Authority
- ES
- Spain
- Prior art keywords
- covalently bound
- antithrombin
- preparation
- iii complex
- bound heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DE UN COMPLEJO COVALENTEMENTE ENLAZADO DE HEPARINA ANTITROMBINA-III. COMPRENDE: A) PONER EN CONTACTO HEPARINA NO FRACCIONADA, CONTENIENDO COMPONENTES DE GRADOS VARIABLES DE ACTIVIDAD, CON BROMURO DE CIANOGENO PARA OBTENER UN INTERMEDIO DE HEPARINA ACTIVADO; B) PONER EN CONTACTO EL INTERMEDIO DE HEPARINA ACTIVADO DE LA ETAPA A) CON ANTITROMBINA III (AT-III); C) PROCESAR EL PRODUCTO OBTENIDO EN LA ETAPA B) PARA SEPARAR LA HEPARINA LIBRE DEL MISMO, POR TECNICAS DE CROMATOGRAFIA DE AFINIDAD, EMPLEANDO UNA MATRIZ INSOLUBLE EN AGUA CONTENIENDO LECITINA COMO ABSORBENTE DE LA COLUMNA; D) SEPARAR DEL PRODUCTO OBTENIDO EN B) EL AT-III LIBRE, POR CROMATOGRAFIA DE AFINIDAD, EMPLEANDO UNA MATRIZ NO HIDROSOLUBLE CONTENIENDO HEPARINA COMO ABSORBENTE DE LA COLUMNA; Y E) COMBINAR EL PRODUCTO, UNA VEZ EXTRAIDAS LAS HEPARINA Y AT-III LIBRES, CON UN VEHICULO FARMACEUTICAMENTE ACEPTABLE. SE UTILIZA EN FARMACOLOGIA, PARA LA PREVENCION Y EL TRATAMIENTO DE LA TROMBOEMBOLIA EN HUMANOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/536,072 US4689323A (en) | 1983-09-26 | 1983-09-26 | Covalently bound heparin--antithrombin-III complex |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604623A1 true ES8604623A1 (es) | 1986-02-01 |
ES536055A0 ES536055A0 (es) | 1986-02-01 |
Family
ID=24137020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536055A Expired ES8604623A1 (es) | 1983-09-26 | 1984-09-19 | Un procedimiento para la produccion de un complejo covalentemente enlazado de heparina-antitrombina-iii |
Country Status (7)
Country | Link |
---|---|
US (1) | US4689323A (es) |
EP (1) | EP0137356B1 (es) |
AT (1) | ATE44156T1 (es) |
AU (1) | AU573262B2 (es) |
CA (1) | CA1240264A (es) |
DE (1) | DE3478749D1 (es) |
ES (1) | ES8604623A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
US4900723A (en) * | 1988-04-29 | 1990-02-13 | E. R. Squibb & Sons, Inc. | Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination |
DK148890D0 (da) * | 1990-06-19 | 1990-06-19 | Novo Nordisk As | Farmaceutisk praeparat |
US5599677A (en) * | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
US6106866A (en) * | 1995-07-31 | 2000-08-22 | Access Pharmaceuticals, Inc. | In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6491965B1 (en) * | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
AT405905B (de) * | 1997-03-25 | 1999-12-27 | Immuno Ag | Neue verwendung von antithrombin iii |
JP3096737B1 (ja) * | 1999-07-19 | 2000-10-10 | 工業技術院長 | ヒト・動物細胞培養液 |
WO2002058638A2 (en) * | 2001-01-26 | 2002-08-01 | The General Hospital Corporation | Serpin drugs for treatment of hiv infection and method of use thereof |
US8563693B2 (en) * | 2001-01-26 | 2013-10-22 | Acceleration Biopharmaceuticals, Inc. | Method of treating human immunodeficiency virus infection in a mammal comprising administering heparin-activated antithrombin III |
US20210308228A1 (en) * | 2020-04-04 | 2021-10-07 | The Board Of Regents Of The University Of Texas System | Method for reducing the occurrence of thrombosis or thromboembolism |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301153A (en) * | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
JPS6040859B2 (ja) * | 1977-07-27 | 1985-09-12 | 喜温 三浦 | 抗血栓性人工医療材料 |
US4446126A (en) * | 1980-09-30 | 1984-05-01 | Cutter Laboratories, Inc. | Antithrombin-heparin complex and method for its production |
EP0048898B1 (en) * | 1980-09-30 | 1985-04-17 | Bayer Ag | Method for the production of an antithrombin-heparin complex and pharmaceutical compositions containing the complex |
DE3038163A1 (de) * | 1980-10-09 | 1982-05-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Thrombininhibitor, seine herstellung und verwendung |
-
1983
- 1983-09-26 US US06/536,072 patent/US4689323A/en not_active Expired - Lifetime
-
1984
- 1984-09-17 AT AT84111048T patent/ATE44156T1/de not_active IP Right Cessation
- 1984-09-17 DE DE8484111048T patent/DE3478749D1/de not_active Expired
- 1984-09-17 EP EP84111048A patent/EP0137356B1/en not_active Expired
- 1984-09-19 ES ES536055A patent/ES8604623A1/es not_active Expired
- 1984-09-21 CA CA000463807A patent/CA1240264A/en not_active Expired
- 1984-09-26 AU AU33568/84A patent/AU573262B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA1240264A (en) | 1988-08-09 |
DE3478749D1 (en) | 1989-07-27 |
AU3356884A (en) | 1985-04-04 |
EP0137356A3 (en) | 1986-05-14 |
AU573262B2 (en) | 1988-06-02 |
US4689323A (en) | 1987-08-25 |
ATE44156T1 (de) | 1989-07-15 |
EP0137356A2 (en) | 1985-04-17 |
EP0137356B1 (en) | 1989-06-21 |
ES536055A0 (es) | 1986-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20051110 |