ES8604580A1 - Procedimiento para preparar derivados de lisergol - Google Patents

Procedimiento para preparar derivados de lisergol

Info

Publication number
ES8604580A1
ES8604580A1 ES545961A ES545961A ES8604580A1 ES 8604580 A1 ES8604580 A1 ES 8604580A1 ES 545961 A ES545961 A ES 545961A ES 545961 A ES545961 A ES 545961A ES 8604580 A1 ES8604580 A1 ES 8604580A1
Authority
ES
Spain
Prior art keywords
effected
ester
lysergol
lumilysergol
h2so4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545961A
Other languages
English (en)
Other versions
ES545961A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inverni Della Beffa SpA
Original Assignee
Inverni Della Beffa SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inverni Della Beffa SpA filed Critical Inverni Della Beffa SpA
Publication of ES8604580A1 publication Critical patent/ES8604580A1/es
Publication of ES545961A0 publication Critical patent/ES545961A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE LISERGOL. COMPRENDE: A) SOMETER A REACCION FOTOQUIMICA, UN ESTER DE LISERGOL DE FORMULA (II), A UNA TEMPERATURA INFERIOR A 0JC, EN METANOL CONTENIENDO NO MAS DE 10% (GR/MLS) DE ACIDO SULFURICO, PARA PRODUCIR UN ESTER DE FORMULA (III); Y B) CONVERTIR EL ESTER RESULTANTE DE A) EN UN COMPUESTO DE FORMULA (I), MEDIANTE UNA O MAS DE LAS ETAPAS: B1), N0METILACION; B2), HIDROLISIS PARA FORMAR UN COMPUESTO EN DONDE OR2 ES HIDROXILO; B3), ESTERIFICACION DE UN COMPUESTO EN DONDE OR2 ES HIDROXILO PARA FORMAR UN COMPUESTO EN DONDE OR2 ES UN GRUPO HIDROXILO ESTERIFICADO; Y B4) TRANSESTERIFICACION DE UN COMPUESTO EN DONDE OR2 ES UN GRUPO HIDROXILO ESTERIFICADO. SIENDO: -OR2 GRUPO HIDROXILO LIBRE O ESTERIFICADI; -OR3, GRUPO HIDROXILO ESTERIFICADO; R1, H O METILO.
ES545961A 1984-08-07 1985-08-07 Procedimiento para preparar derivados de lisergol Expired ES8604580A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8422245A IT1213206B (it) 1984-08-07 1984-08-07 Procedimento per la preparazione di derivati del lisergolo.

Publications (2)

Publication Number Publication Date
ES8604580A1 true ES8604580A1 (es) 1986-02-01
ES545961A0 ES545961A0 (es) 1986-02-01

Family

ID=11193591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545961A Expired ES8604580A1 (es) 1984-08-07 1985-08-07 Procedimiento para preparar derivados de lisergol

Country Status (11)

Country Link
US (1) US4870179A (es)
EP (1) EP0171988B1 (es)
JP (1) JPH0747587B2 (es)
AT (1) ATE44148T1 (es)
CA (1) CA1300127C (es)
DE (1) DE3571133D1 (es)
ES (1) ES8604580A1 (es)
GR (1) GR851919B (es)
IT (1) IT1213206B (es)
MX (1) MX160725A (es)
PT (1) PT80912B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8515528D0 (en) * 1985-06-19 1985-07-24 Erba Farmitalia Ergoline derivatives
GB8608893D0 (en) * 1986-04-11 1986-05-14 Erba Farmitalia D-nor-7-ergoline derivatives
GB8615471D0 (en) * 1986-06-25 1986-07-30 Erba Farmitalia T-butyl ergoline derivatives
CH674367A5 (es) * 1987-06-16 1990-05-31 Arysearch Arylan Ag
CN102718761A (zh) * 2012-05-29 2012-10-10 珠海润都制药股份有限公司 尼麦角林的制备方法
WO2014195849A2 (en) * 2013-06-03 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of cerebrovascular diseases
CN110102234A (zh) * 2019-06-21 2019-08-09 山东方明药业集团股份有限公司 一种光反应生产设备

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228943A (en) * 1962-06-11 1966-01-11 Lumilysergol derivatives
FR7775M (es) * 1967-06-28 1970-03-23
YU33967B (en) * 1969-05-13 1978-09-08 Farmaceutici Italia Process for preparing lumilysergic acid derivatives
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
IT1094965B (it) * 1978-04-05 1985-08-10 Corvi Mora E Procedimento di preparazione di derivati del lisergolo
JPS5661376A (en) * 1979-10-09 1981-05-26 Corvi Mora E Manufacture of lysergol derivative
IT1173489B (it) * 1984-03-27 1987-06-24 Inverni Della Beffa Spa Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione

Also Published As

Publication number Publication date
JPS6147481A (ja) 1986-03-07
IT1213206B (it) 1989-12-14
IT8422245A0 (it) 1984-08-07
ES545961A0 (es) 1986-02-01
CA1300127C (en) 1992-05-05
EP0171988A2 (en) 1986-02-19
EP0171988B1 (en) 1989-06-21
MX160725A (es) 1990-04-27
ATE44148T1 (de) 1989-07-15
PT80912A (en) 1985-09-01
US4870179A (en) 1989-09-26
EP0171988A3 (en) 1986-11-20
GR851919B (es) 1985-12-03
PT80912B (pt) 1987-09-30
DE3571133D1 (en) 1989-07-27
JPH0747587B2 (ja) 1995-05-24

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