Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rocador SA
Original Assignee
Rocador SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rocador SAfiledCriticalRocador SA
Priority to ES548679ApriorityCriticalpatent/ES8604537A1/es
Publication of ES8604537A1publicationCriticalpatent/ES8604537A1/es
Publication of ES548679A0publicationCriticalpatent/ES548679A0/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Thiazole And Isothizaole Compounds
(AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE LA N-SULFAMOIL-3-(2-GUANIDINOTIAZOL-4-IL-METILTIO)PROPIONAMIDINA, DE FORMULA (I). CONSISTE EN LA REACCION DE 2-GUANIDINO-4-HIDROXIMETILTIAZOL CON LA N-SULFAMOIL-3-MERCAPTOPROPIONAMIDINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO ANHIDRO, TAL COMO DIMETILFORMAMIDA O DIMETILSULFOXIDO, EN PRESENCIA DE UNA BASE FUERTE, TAL COMO HIDRURO SODICO, Y DEL YODURO DE N,N-METILFENILAMINOTRIFENILFOSFONIO, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 100JC. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS ULCERAS DEL APARATO DIGESTIVO.
ES548679A1985-11-081985-11-08Procedimiento para la obtencion de la n-sulfamoil-3-(2-gua- nidinotiazol-4-il-metiltio)propionamidina
ExpiredES8604537A1
(es)