ES8604262A1 - Procedimiento de preparacion de aspartil-fenilalanina-metil-ester - Google Patents

Procedimiento de preparacion de aspartil-fenilalanina-metil-ester

Info

Publication number
ES8604262A1
ES8604262A1 ES529469A ES529469A ES8604262A1 ES 8604262 A1 ES8604262 A1 ES 8604262A1 ES 529469 A ES529469 A ES 529469A ES 529469 A ES529469 A ES 529469A ES 8604262 A1 ES8604262 A1 ES 8604262A1
Authority
ES
Spain
Prior art keywords
alkyl ester
prepn
aspartyl
phenylalanine
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529469A
Other languages
English (en)
Other versions
ES529469A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Priority to ES529469A priority Critical patent/ES8604262A1/es
Priority to EP84107902A priority patent/EP0143881A3/de
Priority to FI842743A priority patent/FI842743A/fi
Priority to DK338584A priority patent/DK338584A/da
Priority to NO842802A priority patent/NO842802L/no
Priority to DD84265160A priority patent/DD219025A7/xx
Priority to HU842725A priority patent/HUT34999A/hu
Priority to CS845460A priority patent/CZ546084A3/cs
Priority to RO84115323A priority patent/RO90400A/ro
Priority to PT79022A priority patent/PT79022B/pt
Priority to BR8404378A priority patent/BR8404378A/pt
Priority to IL72841A priority patent/IL72841A0/xx
Publication of ES529469A0 publication Critical patent/ES529469A0/es
Publication of ES8604262A1 publication Critical patent/ES8604262A1/es
Expired legal-status Critical Current

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  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE ASPARTIL-FENILALANINA-METIL-ESTER. COMPRENDE: A) TRATAR A UN COMPUESTO DE FORMULA (I) CON HIDROCLORURO DE N,N-DIMETILFORMAMIDA O DE N,N-DIMETILACETAMIDA, ENTRE C40J Y B20JC, PARA OBTENER UN COMPUESTO DE FORMULA (II); B) TRATAR A (II) CON UN CLORURO DE ACIDO DE FORMULA (R-CO-CL), ENTRE C60J Y B5JC, PARA CONSEGUIR UN COMPUESTO DE FORMULA (III); C) HACER REACCIONAR A (III) CON FENIL-ALANINA-METIL-ESTER, ENTRE C60JC Y B5JC, PARA DAR UN COMPUESTO DE FORMULA (IV); D) HIDROLIZAR A (IV) CON CLORHIDRICO, HASTA UN PH ENTRE 0 Y 1, PARA REALIZAR A (A); Y E) TRATAR A (A) CON HIDROXIDO SODICO O HIDROXIDO POTASICO HASTA UN PH ENTRE 4,5 Y 5, PARA OBTENER EL ASPARTIL-FENILALAMINA-METIL-ESTER. SIENDO: X E Y, LI, NA O K; Z, O O S; R, ALQUILICO DE C 8 A 30; Y R PIVALOIL ACETIL Y OTROS. SE UTILIZAN COMO EDULCORANTES ACALORICOS.
ES529469A 1983-09-07 1984-02-06 Procedimiento de preparacion de aspartil-fenilalanina-metil-ester Expired ES8604262A1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES529469A ES8604262A1 (es) 1984-02-06 1984-02-06 Procedimiento de preparacion de aspartil-fenilalanina-metil-ester
EP84107902A EP0143881A3 (de) 1983-09-07 1984-07-06 Verfahren zur Herstellung eines alpha-L-Aspartyl-L-Phenylalanin-alkylesters
FI842743A FI842743A (fi) 1983-09-07 1984-07-09 Foerfarande foer framstaellning av -l-aspartyl-l-fenylalaninalkylester.
DK338584A DK338584A (da) 1983-09-07 1984-07-10 Fremgangsmaade til fremstilling af alfa-l-aspartyl-l-phenylalaninalkylestere
NO842802A NO842802L (no) 1983-09-07 1984-07-10 Fremgangsmaate for fremstilling av alfa-l-aspartyl-l-fenyl-alanin-alkylestere
DD84265160A DD219025A7 (de) 1983-09-07 1984-07-11 Verfahren zur herstellung von alpha-l-aspartyl-l-phenylalanin-alkylester
HU842725A HUT34999A (en) 1983-09-07 1984-07-12 Process for preparing alkyl esters of alpha-l-aspartyl l-phenyl-alanina
CS845460A CZ546084A3 (en) 1983-09-07 1984-07-13 Process for preparing l-aspartyl-l-phenylalanine-c(1-4)-alkyl esters
RO84115323A RO90400A (ro) 1983-09-07 1984-07-23 Procedeu pentru prepararea esterilor alchilici inferiori ai & aspartil-l-fenilalaninei
PT79022A PT79022B (pt) 1983-09-07 1984-08-02 Verfahren zur herstellung von alpha-l-aspartyl-l-phenylalaninalkylester
BR8404378A BR8404378A (pt) 1983-09-07 1984-08-31 Processo de preparacao de ester alquilico de a-l-aspartil-l-fenila lanina e processo de preparacao de compostos
IL72841A IL72841A0 (en) 1983-09-07 1984-09-02 Process for the preparation of a dipeptide alkyl ester and a novel intermediate used in said process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES529469A ES8604262A1 (es) 1984-02-06 1984-02-06 Procedimiento de preparacion de aspartil-fenilalanina-metil-ester

Publications (2)

Publication Number Publication Date
ES529469A0 ES529469A0 (es) 1986-02-01
ES8604262A1 true ES8604262A1 (es) 1986-02-01

Family

ID=8486827

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529469A Expired ES8604262A1 (es) 1983-09-07 1984-02-06 Procedimiento de preparacion de aspartil-fenilalanina-metil-ester

Country Status (1)

Country Link
ES (1) ES8604262A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042417A1 (es) * 1992-05-18 1993-12-01 Genesis Para La Investigacion Procedimiento de obtencion de alfa-aspartame.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042417A1 (es) * 1992-05-18 1993-12-01 Genesis Para La Investigacion Procedimiento de obtencion de alfa-aspartame.

Also Published As

Publication number Publication date
ES529469A0 (es) 1986-02-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603