ES8603509A1 - Procedimiento para preparar compuestos esteroides 2-alfa-ciano-4 alfa,5 alfa epoxi-3-oxo y (2,3-d) hetero-sustituidos. - Google Patents
Procedimiento para preparar compuestos esteroides 2-alfa-ciano-4 alfa,5 alfa epoxi-3-oxo y (2,3-d) hetero-sustituidos.Info
- Publication number
- ES8603509A1 ES8603509A1 ES537181A ES537181A ES8603509A1 ES 8603509 A1 ES8603509 A1 ES 8603509A1 ES 537181 A ES537181 A ES 537181A ES 537181 A ES537181 A ES 537181A ES 8603509 A1 ES8603509 A1 ES 8603509A1
- Authority
- ES
- Spain
- Prior art keywords
- particle size
- reduced particle
- steroid
- compoundshaving
- size form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS ESTEROIDALES CON UN TAMAÑO DE PARTICULA DENTRO DE UNA GAMA DESEADA Y ESPECIFICA. CONSISTE EN DISOLVER COMPUESTOS ESTEROIDALES DE FORMULAS GENERALES (II) O (III) EN DIMETILFORMAMIDA O ACETONA Y PRECIPITAR EL COMPUESTO MEZCLANDOLO CON AGUA DURANTE UN PERIODO DE TIEMPO DE 4 A 10 MINUTOS, CONTROLANDO LAS CONDICIONES DE MEZCLA PARA PRODUCIR UN PRECIPITADO CON UN DIAMETRO DE VOLUMEN ESFERICO EQUIVALENTE MEDIO ENTRE 4 Y 12 MICRAS. ESTA GAMA DE TAMAÑOS DE PARTICULA POSEE UNA BIODISPONIBILIDAD OPTIMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838328929A GB8328929D0 (en) | 1983-10-29 | 1983-10-29 | Steroid compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES537181A0 ES537181A0 (es) | 1985-12-16 |
ES8603509A1 true ES8603509A1 (es) | 1985-12-16 |
Family
ID=10550923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537181A Expired ES8603509A1 (es) | 1983-10-29 | 1984-10-29 | Procedimiento para preparar compuestos esteroides 2-alfa-ciano-4 alfa,5 alfa epoxi-3-oxo y (2,3-d) hetero-sustituidos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4605517A (es) |
EP (1) | EP0142309B1 (es) |
AT (1) | ATE49217T1 (es) |
DE (1) | DE3480929D1 (es) |
DK (1) | DK511184A (es) |
ES (1) | ES8603509A1 (es) |
FI (1) | FI81362C (es) |
GB (2) | GB8328929D0 (es) |
GR (1) | GR80795B (es) |
NO (1) | NO159385C (es) |
PT (1) | PT79423B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8504486A1 (es) | 1982-11-02 | 1985-05-01 | Sterwin Ag | Procedimiento de trituracion de compuestos esteroides |
US6458811B1 (en) | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
UA72922C2 (uk) | 1999-08-03 | 2005-05-16 | Ліллі Айкос Ллк | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ З <font face="Symbol">b</font>-КАРБОЛІНОМ (ВАРІАНТИ) ТА СПОСІБ ЛІКУВАННЯ СЕКСУАЛЬНОЇ ДИСФУНКЦІЇ |
GB2375958B (en) * | 2001-04-09 | 2005-03-02 | George Margetts | The use of steroids to lower the levels of cortisol |
CN100404545C (zh) * | 2003-03-27 | 2008-07-23 | 尼科梅德有限责任公司 | 具有规定粒径的结晶环缩松的制备方法 |
MY143936A (en) * | 2003-03-27 | 2011-07-29 | Nycomed Gmbh | Process for preparing crystalline ciclesonide with defined particle size |
GB2400554B (en) * | 2003-04-16 | 2007-04-18 | George Margetts | Treatment of angiotensin II-induced cardiovascular disease |
GB2414238B (en) * | 2004-05-22 | 2006-12-13 | Stegram Pharmaceuticals Ltd | Method for the preparation of trilostane |
CA2653384C (en) | 2006-06-30 | 2017-03-14 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
CA3084564A1 (en) | 2017-12-04 | 2019-06-13 | Nanollose Limited | Methods for producing a viscose dope from microbial cellulose |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB911815A (en) * | 1958-03-24 | 1962-11-28 | Sterling Drug Inc | Steroid compounds and preparation thereof |
NL241544A (es) * | 1958-07-23 | |||
GB1009912A (en) * | 1960-11-23 | 1965-11-17 | Merck & Co Inc | Steroid compounds |
GB1123770A (en) * | 1966-11-15 | 1968-08-14 | Sterling Drug Inc | 2-cyano-3-oxo-steroids |
US4277409A (en) * | 1977-03-18 | 1981-07-07 | Roussel Uclaf | Preparation of 9α-fluoro-16α-methyl-21-acetoxy-Δ1,4 -pregnadiene-11β-ol-3,20-dione |
US4160027A (en) * | 1977-12-20 | 1979-07-03 | Sterling Drug Inc. | Steroid cyanoketones and intermediates |
US4391755A (en) * | 1982-01-18 | 1983-07-05 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
ES8504486A1 (es) * | 1982-11-02 | 1985-05-01 | Sterwin Ag | Procedimiento de trituracion de compuestos esteroides |
US4459235A (en) * | 1983-03-03 | 1984-07-10 | G. D. Searle & Co. | 2-Cyanosteroids |
-
1983
- 1983-10-29 GB GB838328929A patent/GB8328929D0/en active Pending
-
1984
- 1984-10-11 US US06/659,594 patent/US4605517A/en not_active Expired - Fee Related
- 1984-10-26 DK DK511184A patent/DK511184A/da not_active Application Discontinuation
- 1984-10-26 PT PT79423A patent/PT79423B/pt not_active IP Right Cessation
- 1984-10-29 FI FI844238A patent/FI81362C/fi not_active IP Right Cessation
- 1984-10-29 AT AT84307432T patent/ATE49217T1/de not_active IP Right Cessation
- 1984-10-29 EP EP84307432A patent/EP0142309B1/en not_active Expired - Lifetime
- 1984-10-29 GR GR80795A patent/GR80795B/el unknown
- 1984-10-29 NO NO844300A patent/NO159385C/no unknown
- 1984-10-29 GB GB08427300A patent/GB2148899B/en not_active Expired
- 1984-10-29 DE DE8484307432T patent/DE3480929D1/de not_active Expired - Fee Related
- 1984-10-29 ES ES537181A patent/ES8603509A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2148899B (en) | 1987-07-22 |
DK511184D0 (da) | 1984-10-26 |
DE3480929D1 (de) | 1990-02-08 |
FI844238L (fi) | 1985-04-30 |
EP0142309B1 (en) | 1990-01-03 |
PT79423B (en) | 1986-11-13 |
EP0142309A3 (en) | 1986-02-12 |
NO159385B (no) | 1988-09-12 |
FI844238A0 (fi) | 1984-10-29 |
NO159385C (no) | 1988-12-21 |
NO844300L (no) | 1985-04-30 |
FI81362B (fi) | 1990-06-29 |
ES537181A0 (es) | 1985-12-16 |
US4605517A (en) | 1986-08-12 |
EP0142309A2 (en) | 1985-05-22 |
GB2148899A (en) | 1985-06-05 |
ATE49217T1 (de) | 1990-01-15 |
GR80795B (en) | 1985-03-01 |
DK511184A (da) | 1985-04-30 |
PT79423A (en) | 1984-11-01 |
FI81362C (fi) | 1990-10-10 |
GB8328929D0 (en) | 1983-11-30 |
GB8427300D0 (en) | 1984-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960401 |