ES8603260A1 - Un procedimiento para formar pequenas particular de un compuesto organico debilmente acido o basico, tal como sulfadiazina, lidocaina y otros compuestos farmaceuticamente activos. - Google Patents

Un procedimiento para formar pequenas particular de un compuesto organico debilmente acido o basico, tal como sulfadiazina, lidocaina y otros compuestos farmaceuticamente activos.

Info

Publication number
ES8603260A1
ES8603260A1 ES533586A ES533586A ES8603260A1 ES 8603260 A1 ES8603260 A1 ES 8603260A1 ES 533586 A ES533586 A ES 533586A ES 533586 A ES533586 A ES 533586A ES 8603260 A1 ES8603260 A1 ES 8603260A1
Authority
ES
Spain
Prior art keywords
small particle
particle formation
change
temperature
formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533586A
Other languages
English (en)
Other versions
ES533586A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Publication of ES8603260A1 publication Critical patent/ES8603260A1/es
Publication of ES533586A0 publication Critical patent/ES533586A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21C—PROCESSING OF PIG-IRON, e.g. REFINING, MANUFACTURE OF WROUGHT-IRON OR STEEL; TREATMENT IN MOLTEN STATE OF FERROUS ALLOYS
    • C21C1/00—Refining of pig-iron; Cast iron
    • C21C1/04—Removing impurities other than carbon, phosphorus or sulfur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO PARA FORMAR PEQUEÑAS PARTICULAS DE UN COMPUESTO ORGANICO DEBILMENTE ACIDO O BASICO, TAL COMO SULFADIAZINA, LIDOCAINA Y OTROS COMPUESTOS FARMACEUTICAMENTE ACTIVOS. COMPRENDE: A) DISOLVER EL COMPUESTO EN AGUA, EN PRESENCIA DE SUFICIENTE CANTIDAD DE BASE O ACIDO PARA MODIFICAR EL PH HASTA UN PRIMER PH CON UN AGENTE TENSIOACTIVO ANIONICO O CATIONICO, QUE MANTIENE SU CONDICION IONICA ENTRE EL PRIMERO Y SEGUNDO PH Y UN AGENTE TENSIOACTIVO ANFOTERO CUYA NATURALEZA CATIONICA O ANIONICA AUMENTA DESDE EL PRIMER AL SEGUNDO PH; Y B) AGITAR Y TITULAR LA SOLUCION CON UN TITULANTE EFICAZ A UNA TEMPERATURA DE 0 A 50JC, PARA MODIFICAR EL PH DE LA SOLUCION HASTA EL SEGUNDO PH Y PROVOCAR LA FORMACION DE UN COACERVADO DE LOS AGENTES TENSIOACTIVOS ANIONICO O CATIONICO Y ANFOTERO, Y LA PRECIPITACION DEL COMPUESTO EN FORMA DE PARTICULAS PEQUEÑAS. LA SOLUBILIDAD EN AGUA DEL COMPUESTO ORGANICO ES MAYOR A UN PRIMER PH QUE A UN SEGUNDO PH.
ES533586A 1983-06-22 1984-06-20 Un procedimiento para formar pequenas particular de un compuesto organico debilmente acido o basico, tal como sulfadiazina, lidocaina y otros compuestos farmaceuticamente activos. Granted ES533586A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50659883A 1983-06-22 1983-06-22

Publications (2)

Publication Number Publication Date
ES8603260A1 true ES8603260A1 (es) 1985-12-16
ES533586A0 ES533586A0 (es) 1985-12-16

Family

ID=24015256

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533586A Granted ES533586A0 (es) 1983-06-22 1984-06-20 Un procedimiento para formar pequenas particular de un compuesto organico debilmente acido o basico, tal como sulfadiazina, lidocaina y otros compuestos farmaceuticamente activos.

Country Status (15)

Country Link
EP (1) EP0130160B1 (es)
JP (1) JPS60501594A (es)
KR (1) KR910008364B1 (es)
AT (1) ATE31635T1 (es)
CA (1) CA1245631A (es)
CY (1) CY1557A (es)
DE (1) DE3468336D1 (es)
DK (1) DK167308B1 (es)
ES (1) ES533586A0 (es)
HK (1) HK70590A (es)
IL (1) IL72104A (es)
MY (1) MY102055A (es)
NZ (1) NZ208580A (es)
PH (1) PH22911A (es)
SG (1) SG55590G (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
US4794000A (en) * 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
SI22751A (sl) * 2008-04-03 2009-10-31 Krka, D.D., Novo Mesto Toltrazuril z izboljĺ animi lastnostmi za raztapljanje
WO2014010778A1 (ko) 2012-07-10 2014-01-16 주식회사 포스코엘이디 광 반도체 조명장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1350389A (en) * 1970-08-26 1974-04-18 Atomic Energy Authority Uk Processes for precipitating metal compounds
GB1382435A (en) * 1971-11-22 1975-01-29 Squibb & Sons Inc Free flowing epicillin
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
LU84530A1 (fr) * 1982-12-13 1984-10-22 Midit Procede de preparation d'acide p-butoxyphenylacethydroxamique a l'etat finement divise et composition contenant cet acide

Also Published As

Publication number Publication date
KR910008364B1 (ko) 1991-10-12
IL72104A (en) 1988-03-31
KR850000258A (ko) 1985-02-26
DK59185D0 (da) 1985-02-08
JPH0456659B2 (es) 1992-09-09
EP0130160B1 (en) 1988-01-07
MY102055A (en) 1992-03-31
NZ208580A (en) 1986-11-12
DK167308B1 (da) 1993-10-11
HK70590A (en) 1990-09-14
EP0130160A2 (en) 1985-01-02
CA1245631A (en) 1988-11-29
IL72104A0 (en) 1984-10-31
DE3468336D1 (en) 1988-02-11
JPS60501594A (ja) 1985-09-26
SG55590G (en) 1990-09-07
PH22911A (en) 1989-01-24
EP0130160A3 (en) 1985-07-10
DK59185A (da) 1985-02-08
CY1557A (en) 1991-03-22
ATE31635T1 (de) 1988-01-15
ES533586A0 (es) 1985-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001002