ES8602815A1 - Cephalosporins - Google Patents

Cephalosporins

Info

Publication number
ES8602815A1
ES8602815A1 ES527333A ES527333A ES8602815A1 ES 8602815 A1 ES8602815 A1 ES 8602815A1 ES 527333 A ES527333 A ES 527333A ES 527333 A ES527333 A ES 527333A ES 8602815 A1 ES8602815 A1 ES 8602815A1
Authority
ES
Spain
Prior art keywords
group
formula
image
hydrogen atom
cephalosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527333A
Other languages
Spanish (es)
Other versions
ES527333A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57200382A external-priority patent/JPS5993085A/en
Priority claimed from JP58067871A external-priority patent/JPS59193893A/en
Priority claimed from JP58199945A external-priority patent/JPS6092293A/en
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES527333A0 publication Critical patent/ES527333A0/en
Publication of ES8602815A1 publication Critical patent/ES8602815A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporins of formula < IMAGE > wherein -A- represents a group of the formula, -CH2- or a group of the formula, < IMAGE > in which R<18> represents a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, heterocyclic group or a hydroxyl-protecting group or a group of the formula, < IMAGE > (each of R<19> and R<20>, which may be the same or different, represents a hydroxyl, alkyl, aralkyl, aryl, alkoxy, aralkyloxy or aryloxy group), and the bond @ means that the compound may be a syn-isomer or an anti-isomer or a mixture thereof R<1> is H or carboxyl-protecting group R<2> is a substituted or unsubstituted 2,3- dioxo-1,2,3,4-tetrahydropyrazinyl, 2-oxo-1,2-dihydropyrazinyl, 3,6-dioxo- 1,2,3,6-tetrahydropyridazinyl or 6-oxo-1,6-dihydropyridazinyl group R<3> is H or alkoxy R<4> represents a hydrogen atom or a halogen atom and R<5> represents a hydrogen atom or a protected or unprotected amino group. These cephalosporins have a broad antibacterial spectrum, are stable against beta -lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally. Intermediates of formula: < IMAGE > where R<1> to R<3> are as above and R<28> is amino are also disclosed.
ES527333A 1982-11-17 1983-11-16 Cephalosporins Expired ES8602815A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP57200382A JPS5993085A (en) 1982-11-17 1982-11-17 Novel cephalosporin compound
JP58067871A JPS59193893A (en) 1983-04-19 1983-04-19 Novel cephalosporins
JP58199945A JPS6092293A (en) 1983-10-27 1983-10-27 Novel cephalosporin compound

Publications (2)

Publication Number Publication Date
ES527333A0 ES527333A0 (en) 1985-12-01
ES8602815A1 true ES8602815A1 (en) 1985-12-01

Family

ID=27299565

Family Applications (3)

Application Number Title Priority Date Filing Date
ES527333A Expired ES8602815A1 (en) 1982-11-17 1983-11-16 Cephalosporins
ES544724A Expired ES8607321A1 (en) 1982-11-17 1985-06-28 Cephalosporins
ES544723A Expired ES8607320A1 (en) 1982-11-17 1985-06-28 Cephalosporins

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES544724A Expired ES8607321A1 (en) 1982-11-17 1985-06-28 Cephalosporins
ES544723A Expired ES8607320A1 (en) 1982-11-17 1985-06-28 Cephalosporins

Country Status (12)

Country Link
KR (1) KR870000611B1 (en)
AU (2) AU549861B2 (en)
BE (1) BE898249A (en)
CA (2) CA1253486A (en)
CH (2) CH660010A5 (en)
DE (2) DE3347928C2 (en)
DK (1) DK521883A (en)
ES (3) ES8602815A1 (en)
FI (1) FI75827C (en)
FR (1) FR2536074B1 (en)
GB (2) GB2131800B (en)
NL (1) NL192792C (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6064986A (en) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd Production of cephalosporin
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
AT397086B (en) * 1984-05-25 1994-01-25 Toyama Chemical Co Ltd Process for the preparation of novel 2-(2-aminothiazol-4- yl)-2-(syn)-alkoxyiminoacetamides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53119885A (en) * 1977-03-29 1978-10-19 Takeda Chem Ind Ltd Cephalosporin derivatives
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
JPS5492986A (en) * 1977-12-28 1979-07-23 Takeda Chem Ind Ltd Cephalosporin derivative
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions

Also Published As

Publication number Publication date
ES8607320A1 (en) 1986-05-16
DE3341591C2 (en) 1988-04-07
ES527333A0 (en) 1985-12-01
NL8303955A (en) 1984-06-18
CH657135A5 (en) 1986-08-15
NL192792B (en) 1997-10-01
BE898249A (en) 1984-05-17
GB2131800B (en) 1986-07-09
GB2171697B (en) 1987-07-01
GB2131800A (en) 1984-06-27
CH660010A5 (en) 1987-03-13
FR2536074A1 (en) 1984-05-18
KR870000611B1 (en) 1987-03-25
FI75827C (en) 1988-08-08
FI834183A0 (en) 1983-11-15
FI834183A (en) 1984-05-18
KR840006668A (en) 1984-12-01
DK521883A (en) 1984-05-18
CA1253486A (en) 1989-05-02
NL192792C (en) 1998-02-03
ES544723A0 (en) 1986-05-16
AU565648B2 (en) 1987-09-24
ES8607321A1 (en) 1986-05-16
AU4742185A (en) 1986-01-02
FI75827B (en) 1988-04-29
CA1276139C (en) 1990-11-13
AU549861B2 (en) 1986-02-20
DE3347928C2 (en) 1993-05-06
GB8330599D0 (en) 1983-12-21
GB8603333D0 (en) 1986-03-19
DE3341591A1 (en) 1984-05-17
AU2142983A (en) 1985-05-23
FR2536074B1 (en) 1986-09-05
ES544724A0 (en) 1986-05-16
GB2171697A (en) 1986-09-03
DK521883D0 (en) 1983-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601