ES8602761A1 - Un procedimiento para preparar un derivado de primidona - Google Patents
Un procedimiento para preparar un derivado de primidonaInfo
- Publication number
- ES8602761A1 ES8602761A1 ES534452A ES534452A ES8602761A1 ES 8602761 A1 ES8602761 A1 ES 8602761A1 ES 534452 A ES534452 A ES 534452A ES 534452 A ES534452 A ES 534452A ES 8602761 A1 ES8602761 A1 ES 8602761A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridyl
- oxo
- methyl
- dimethyl
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Treating Waste Gases (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Impact Printers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDONA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE HAL ES UN ATOMO DE HALOGENO;R5 ES AMINO O DERIVADO DEL MISMO; R6 ES ALQUILENO C1-3; Y R7 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R8 ES AMINO O UN GRUPO AMINO PROTEGIDO, R9 ES UN GRUPO DESPLAZABLE CON AMINA Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN AUSENCIA DE DISOLVENTE O EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE 80C Y LA DE EBULLICION DEL DISOLVENTE ELEGIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL ASMA BRONQUIAL, RINITIS, FIEBRE DEL HENO Y ECZEMAS ALERGICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838319874A GB8319874D0 (en) | 1983-07-23 | 1983-07-23 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8602761A1 true ES8602761A1 (es) | 1985-12-01 |
ES534452A0 ES534452A0 (es) | 1985-12-01 |
Family
ID=10546171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES534452A Granted ES534452A0 (es) | 1983-07-23 | 1984-07-19 | Un procedimiento para preparar un derivado de primidona |
Country Status (23)
Country | Link |
---|---|
US (1) | US4665078A (es) |
EP (1) | EP0134091B1 (es) |
JP (1) | JPS6048986A (es) |
KR (1) | KR850001194A (es) |
AT (1) | ATE27818T1 (es) |
AU (1) | AU3080984A (es) |
CS (1) | CS244446B2 (es) |
DD (1) | DD216463A5 (es) |
DE (1) | DE3464249D1 (es) |
DK (1) | DK359184A (es) |
ES (1) | ES534452A0 (es) |
FI (1) | FI842907A (es) |
GB (1) | GB8319874D0 (es) |
GR (1) | GR79961B (es) |
HU (1) | HUT34745A (es) |
IL (1) | IL72448A0 (es) |
JO (1) | JO1326B1 (es) |
NO (1) | NO842963L (es) |
NZ (1) | NZ208956A (es) |
PL (1) | PL248859A1 (es) |
PT (1) | PT78961A (es) |
RO (1) | RO89219A (es) |
ZA (1) | ZA845622B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT78358B (en) * | 1983-04-07 | 1986-05-30 | Smith Kline French Lab | Chemical process |
ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US10596401B2 (en) | 2016-08-11 | 2020-03-24 | Victaulic Company | Modular valve assembly |
US20180193681A1 (en) | 2017-01-06 | 2018-07-12 | Globe Fire Sprinkler Corporation | Control valve assembly with test, drain and adjustable pressure relief valve |
US11402028B2 (en) | 2018-03-29 | 2022-08-02 | Victaulic Company | Combination control and check valve assembly for a wet piping system |
WO2021055730A1 (en) | 2019-09-20 | 2021-03-25 | Victaulic Company | Ball valve assembly |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4154834A (en) * | 1975-12-29 | 1979-05-15 | Smith Kline & French Laboratories Limited | Substituted isocytosines having histamine H2 -antagonist activity |
IN151188B (es) * | 1978-02-13 | 1983-03-05 | Smith Kline French Lab | |
ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
PT75074B (en) * | 1981-06-27 | 1986-02-26 | Smith Kline French Lab | Process for preparing certain pyrimidone derivatives and compositions containing them |
-
1983
- 1983-07-23 GB GB838319874A patent/GB8319874D0/en active Pending
-
1984
- 1984-07-11 US US06/629,661 patent/US4665078A/en not_active Expired - Lifetime
- 1984-07-16 GR GR75322A patent/GR79961B/el unknown
- 1984-07-17 EP EP84304870A patent/EP0134091B1/en not_active Expired
- 1984-07-17 DE DE8484304870T patent/DE3464249D1/de not_active Expired
- 1984-07-17 AT AT84304870T patent/ATE27818T1/de not_active IP Right Cessation
- 1984-07-18 AU AU30809/84A patent/AU3080984A/en not_active Abandoned
- 1984-07-18 JO JO19841326A patent/JO1326B1/en active
- 1984-07-19 KR KR1019840004245A patent/KR850001194A/ko not_active Application Discontinuation
- 1984-07-19 FI FI842907A patent/FI842907A/fi not_active Application Discontinuation
- 1984-07-19 JP JP59151111A patent/JPS6048986A/ja active Pending
- 1984-07-19 IL IL72448A patent/IL72448A0/xx unknown
- 1984-07-19 NO NO842963A patent/NO842963L/no unknown
- 1984-07-19 CS CS845571A patent/CS244446B2/cs unknown
- 1984-07-19 ES ES534452A patent/ES534452A0/es active Granted
- 1984-07-20 DK DK359184A patent/DK359184A/da not_active Application Discontinuation
- 1984-07-20 HU HU842825A patent/HUT34745A/hu unknown
- 1984-07-20 DD DD84265516A patent/DD216463A5/de unknown
- 1984-07-20 PT PT78961A patent/PT78961A/pt unknown
- 1984-07-20 NZ NZ208956A patent/NZ208956A/en unknown
- 1984-07-20 PL PL24885984A patent/PL248859A1/xx unknown
- 1984-07-20 ZA ZA845622A patent/ZA845622B/xx unknown
- 1984-07-23 RO RO84115322A patent/RO89219A/ro unknown
Also Published As
Publication number | Publication date |
---|---|
JO1326B1 (en) | 1986-11-30 |
HUT34745A (en) | 1985-04-28 |
EP0134091B1 (en) | 1987-06-16 |
EP0134091A1 (en) | 1985-03-13 |
FI842907A (fi) | 1985-01-24 |
DK359184A (da) | 1985-01-24 |
KR850001194A (ko) | 1985-03-16 |
ATE27818T1 (de) | 1987-07-15 |
DK359184D0 (da) | 1984-07-20 |
NZ208956A (en) | 1987-03-06 |
FI842907A0 (fi) | 1984-07-19 |
DE3464249D1 (de) | 1987-07-23 |
RO89219A (ro) | 1986-03-15 |
GB8319874D0 (en) | 1983-08-24 |
JPS6048986A (ja) | 1985-03-16 |
DD216463A5 (de) | 1984-12-12 |
CS557184A2 (en) | 1985-08-15 |
AU3080984A (en) | 1985-01-24 |
ES534452A0 (es) | 1985-12-01 |
NO842963L (no) | 1985-01-24 |
PT78961A (en) | 1984-08-01 |
ZA845622B (en) | 1985-07-31 |
PL248859A1 (en) | 1985-07-16 |
GR79961B (es) | 1984-10-31 |
CS244446B2 (en) | 1986-07-17 |
US4665078A (en) | 1987-05-12 |
IL72448A0 (en) | 1984-11-30 |
Similar Documents
Publication | Publication Date | Title |
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NZ201077A (en) | Preparation of pyrimidone derivatives | |
ES8602761A1 (es) | Un procedimiento para preparar un derivado de primidona |