ES8602746A1 - Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico - Google Patents

Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico

Info

Publication number
ES8602746A1
ES8602746A1 ES541636A ES541636A ES8602746A1 ES 8602746 A1 ES8602746 A1 ES 8602746A1 ES 541636 A ES541636 A ES 541636A ES 541636 A ES541636 A ES 541636A ES 8602746 A1 ES8602746 A1 ES 8602746A1
Authority
ES
Spain
Prior art keywords
gamma
processes
preparation
aminobutyric acid
acid transaminase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541636A
Other languages
English (en)
Other versions
ES541636A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8602746A1 publication Critical patent/ES8602746A1/es
Publication of ES541636A0 publication Critical patent/ES541636A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PRA LA PREPARACION DE DERIVADOS DEL ACIDO 4-AMINO-4,5-DIHIDRO-2-TIOFENCARBOXILICO. CONSISTE EN SOMETER A REACCION DE DESPROTECCION EL CORRESPONDIENTE ACIDO 3-AMINO-4,5-DIHIDRO-2-TIOFENCARBOXILICO N-PROTEGIDO PARA OBTENER DERIVADOS DEL ACIDO 4-AMINO-4,5-DIHIDRO-2-TIOFENCARBOXILICO DE FORMULA (I) DONDE R ES H O ALQUILO DE C 1 A 6 Y SUS SALES Y ENANTIOMEROS INDIVIDUALES Y MEZCLAS RACEMICAS, Y OPCIONALMENTE, ESTERIFICAR EL COMPUESTO OBTENIDO DE FORMULA (I) Y/O FORMAR UNA SAL DEL MISMO. EL GRUPO N-PROTECTOR ES T-BUTOXICARBONILO Y LA DESPROTECCION SE EFECTUA CON HC1 A LA TEMPERATURA DE UN BAÑO DE HIELO. TIENEN APLICACIONES FARMACEUTICAS CON INHIBIDORES DE LA ACIDO-G-AMINOBUTIRICO-TRANSAMINASA, UTILES EN EL TRATAMIENTO DE LA EPILEPSIA.
ES541636A 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico Granted ES541636A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54074583A 1983-10-11 1983-10-11
US54074383A 1983-10-11 1983-10-11
US54074483A 1983-10-11 1983-10-11

Publications (2)

Publication Number Publication Date
ES8602746A1 true ES8602746A1 (es) 1985-12-01
ES541636A0 ES541636A0 (es) 1985-12-01

Family

ID=27415337

Family Applications (4)

Application Number Title Priority Date Filing Date
ES536669A Expired ES8603857A1 (es) 1983-10-11 1984-10-10 Un procedimiento para la preparacion de acido 4-amino-4, 5-dihidro-2-furancarboxilico
ES541636A Granted ES541636A0 (es) 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico
ES541637A Granted ES541637A0 (es) 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico
ES541635A Expired ES8602731A1 (es) 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-(((alcoxi sustituido)carbonil)-amino)-4,5-dihidro-2-furan-carboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES536669A Expired ES8603857A1 (es) 1983-10-11 1984-10-10 Un procedimiento para la preparacion de acido 4-amino-4, 5-dihidro-2-furancarboxilico

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES541637A Granted ES541637A0 (es) 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-amino-4,5-dihidro-2-tiofencarboxilico
ES541635A Expired ES8602731A1 (es) 1983-10-11 1985-03-27 Un procedimiento para la preparacion de derivados del acido 4-(((alcoxi sustituido)carbonil)-amino)-4,5-dihidro-2-furan-carboxilico

Country Status (15)

Country Link
EP (1) EP0145875B1 (es)
JP (1) JPS60104077A (es)
KR (1) KR890001008B1 (es)
AU (1) AU569915B2 (es)
CA (1) CA1241963A (es)
DE (1) DE3485514D1 (es)
DK (1) DK483684A (es)
ES (4) ES8603857A1 (es)
GR (1) GR80568B (es)
HU (1) HU201038B (es)
IE (1) IE57589B1 (es)
IL (1) IL73109A (es)
NO (1) NO168579C (es)
NZ (1) NZ209803A (es)
PT (1) PT79336B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1473757A (en) * 1974-08-05 1977-05-18 Teikoku Chem Ind Co Ltd Ureylenethiophanes and their related compounds and production thereof

Also Published As

Publication number Publication date
ES8602747A1 (es) 1985-12-01
ES536669A0 (es) 1986-01-01
JPH0587513B2 (es) 1993-12-16
HUT36813A (en) 1985-10-28
DK483684D0 (da) 1984-10-10
IE842584L (en) 1985-04-11
NO168579B (no) 1991-12-02
GR80568B (en) 1985-02-07
NO168579C (no) 1992-03-11
ES8603857A1 (es) 1986-01-01
EP0145875A2 (en) 1985-06-26
HU201038B (en) 1990-09-28
IL73109A (en) 1990-02-09
DK483684A (da) 1985-04-12
PT79336A (en) 1984-11-01
CA1241963A (en) 1988-09-13
KR890001008B1 (ko) 1989-04-18
IL73109A0 (en) 1984-12-31
NZ209803A (en) 1987-02-20
ES541635A0 (es) 1985-12-01
DE3485514D1 (de) 1992-03-26
ES541637A0 (es) 1985-12-01
ES8602731A1 (es) 1985-12-01
JPS60104077A (ja) 1985-06-08
PT79336B (en) 1986-09-08
KR850002969A (ko) 1985-05-28
ES541636A0 (es) 1985-12-01
EP0145875A3 (en) 1988-03-02
IE57589B1 (en) 1993-01-13
NO844066L (no) 1985-04-12
EP0145875B1 (en) 1992-02-19
AU569915B2 (en) 1988-02-25
AU3389784A (en) 1985-04-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519