ES8602671A1 - Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester - Google Patents

Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester

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Publication number
ES8602671A1
ES8602671A1 ES542899A ES542899A ES8602671A1 ES 8602671 A1 ES8602671 A1 ES 8602671A1 ES 542899 A ES542899 A ES 542899A ES 542899 A ES542899 A ES 542899A ES 8602671 A1 ES8602671 A1 ES 8602671A1
Authority
ES
Spain
Prior art keywords
nitrate ester
pyridine carboxamide
hydroxyethyl
hydroxyethyl pyridine
nicotinamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542899A
Other languages
English (en)
Other versions
ES542899A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Especialidades Latinas Medicamentos Universales SA
Original Assignee
Especialidades Latinas Medicamentos Universales SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Especialidades Latinas Medicamentos Universales SA filed Critical Especialidades Latinas Medicamentos Universales SA
Priority to ES542899A priority Critical patent/ES8602671A1/es
Publication of ES542899A0 publication Critical patent/ES542899A0/es
Publication of ES8602671A1 publication Critical patent/ES8602671A1/es
Expired legal-status Critical Current

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Abstract

PROCEDIMIENTO DE OBTENCION DE N-(2-HIDROXIETIL)-3-PIRIDINA-CARBOXAMIDA NITRATO ESTER. CONSISTE EN: 1) HACER REACCIONAR NICOTINAMIDA CON CLORHIDRATO DE ETANOLAMINA A 110-125 C DURANTE 15-30 MINUTOS, 2) SEPARAR EL CLORURO AMONICO FORMADO, 3) AÑADIR CLOROFORMO, Y ELIMINAR EL DISOLVENTE A PRESION REDUCIDA, OBTENIENDOSE UN CRUDO DE N(-2-HIDROXIETIL)-NICOTINAMIDA, 4) AÑADIR LENTAMENTE ESTA AMIDA SOBRE ACIDO NITRICO FUMANTE A -10 C, FORMANDOSE EL ESTER NITRICO, QUE POR PRECIPITACION CON ETER, DISOLUCION EN SOLUCION DE NA2CO3 Y EXTRACCION POR ACETATO DE ETILO SE OBTIENE LA N-(2-HIDROXIETIL)-3-PIRIDINA-CRBOXAMIDA NITRATO ESTER DE FORMULA GENERAL (I).
ES542899A 1985-05-08 1985-05-08 Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester Expired ES8602671A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES542899A ES8602671A1 (es) 1985-05-08 1985-05-08 Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES542899A ES8602671A1 (es) 1985-05-08 1985-05-08 Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester

Publications (2)

Publication Number Publication Date
ES542899A0 ES542899A0 (es) 1985-12-01
ES8602671A1 true ES8602671A1 (es) 1985-12-01

Family

ID=8489153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542899A Expired ES8602671A1 (es) 1985-05-08 1985-05-08 Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester

Country Status (1)

Country Link
ES (1) ES8602671A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012089769A1 (en) 2010-12-28 2012-07-05 Procos S.P.A. Process for the manufacture of nicorandil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012089769A1 (en) 2010-12-28 2012-07-05 Procos S.P.A. Process for the manufacture of nicorandil

Also Published As

Publication number Publication date
ES542899A0 (es) 1985-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303