ES8602015A1 - Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan - Google Patents

Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan

Info

Publication number
ES8602015A1
ES8602015A1 ES534339A ES534339A ES8602015A1 ES 8602015 A1 ES8602015 A1 ES 8602015A1 ES 534339 A ES534339 A ES 534339A ES 534339 A ES534339 A ES 534339A ES 8602015 A1 ES8602015 A1 ES 8602015A1
Authority
ES
Spain
Prior art keywords
amino
substd
cpd
opt
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534339A
Other languages
Spanish (es)
Other versions
ES534339A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Priority to ES534339A priority Critical patent/ES8602015A1/en
Priority to US06/752,897 priority patent/US4767851A/en
Priority to EP85401458A priority patent/EP0169144B1/en
Priority to AT85401458T priority patent/ATE53392T1/en
Priority to JP60155331A priority patent/JPS6176493A/en
Priority to DE8585401458T priority patent/DE3578070D1/en
Publication of ES534339A0 publication Critical patent/ES534339A0/en
Publication of ES8602015A1 publication Critical patent/ES8602015A1/en
Expired legal-status Critical Current

Links

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  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Prodn. of 7-(opt.substd. amino) 3-methyl-3-cephem 4-carboxylic acid cpds. (I) is effected by heating the corresp. 6-(substd.amino) penicillanic acid sulphoxide cpd. (II) in the presence of an acidic substance (III) which causes expansion of the penam ring to a 3-cephem ring, and also in the presence of (a) an Si cpd. and sulphamide or (b) a silylsulphamide or silylsulphamoyl (sic.) - In subsidiary claims the starting material is a cpd. of formula (IIa) or (IV). R = alkylsilyl, alkyl or 2-5C acyl, R1 = H or an opt. substd. gp. bonded to N through a C or S atom; R2 = H or a 2-10C acid residue opt. contg. O,S or N; or NR1R2 = phthalimido, oxazolidinyl, imidazolidinyl, NCO, benzylideneamino or hydroxybenzylideneamino; R3 = a hydrolysable gp.
ES534339A 1984-07-16 1984-07-16 Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan Expired ES8602015A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES534339A ES8602015A1 (en) 1984-07-16 1984-07-16 Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan
US06/752,897 US4767851A (en) 1984-07-16 1985-07-08 Process for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins
EP85401458A EP0169144B1 (en) 1984-07-16 1985-07-16 Process for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins from the corresponding 6-substituted amino penicillin sulphoxides
AT85401458T ATE53392T1 (en) 1984-07-16 1985-07-16 PROCESS FOR THE PREPARATION OF 7-AMINO- OR 7-SUBSTITUTE AMINODESACETOXYCEPHALOSPORINS FROM THE MATCHING 6-SUBSTITUTE AMINOPENICILLINSULPHOXIDES.
JP60155331A JPS6176493A (en) 1984-07-16 1985-07-16 Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan
DE8585401458T DE3578070D1 (en) 1984-07-16 1985-07-16 METHOD FOR PRODUCING 7-AMINO OR 7-SUBSTITUTED AMINODESACETOXYCEPHALOSPORINES FROM THE MATCHING 6-SUBSTITUTED AMINOPENICILLINE SULPHOXYDES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES534339A ES8602015A1 (en) 1984-07-16 1984-07-16 Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan

Publications (2)

Publication Number Publication Date
ES534339A0 ES534339A0 (en) 1985-12-01
ES8602015A1 true ES8602015A1 (en) 1985-12-01

Family

ID=8487632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534339A Expired ES8602015A1 (en) 1984-07-16 1984-07-16 Manufacture of 7-amino- 7-substituted amino-desacetoxycephalosporan

Country Status (2)

Country Link
JP (1) JPS6176493A (en)
ES (1) ES8602015A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894211B2 (en) 2001-09-21 2005-05-17 Yamaha Corporation Keyboard apparatus

Also Published As

Publication number Publication date
ES534339A0 (en) 1985-12-01
JPS6176493A (en) 1986-04-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001