ES8601996A1 - Un metodo de preparar derivados de acido hexahidro-3,5-dioxo-1h-pirrolizino-2-carboxilico - Google Patents

Un metodo de preparar derivados de acido hexahidro-3,5-dioxo-1h-pirrolizino-2-carboxilico

Info

Publication number
ES8601996A1
ES8601996A1 ES535456A ES535456A ES8601996A1 ES 8601996 A1 ES8601996 A1 ES 8601996A1 ES 535456 A ES535456 A ES 535456A ES 535456 A ES535456 A ES 535456A ES 8601996 A1 ES8601996 A1 ES 8601996A1
Authority
ES
Spain
Prior art keywords
tri
mono
pyrrolizine
dioxo
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535456A
Other languages
English (en)
Other versions
ES535456A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8601996A1 publication Critical patent/ES8601996A1/es
Publication of ES535456A0 publication Critical patent/ES535456A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE ACIDO HEXAHIDRO-3,5-DIOXO-1H-PIRROLIZIN-2-CARBOXILICO. COMPRENDE: REDUCIR CATALITICAMENTE 5-OXO-PROLINA EN 2-OXO-5-HIDROXIMETILPIRROLIDINA; CONVERTIR LA 2-OXO-5-HIDROXIMETILPIRROLIDINA EN EL DERIVADO P-TOLUOILSULFONILICO POR REACCION CON CLORO DE P-TOLUOILSULFONILO; Y HACER REACCIONAR EL DERIVADO P-TOLUOILSULFONILICO CON LA SAL SODICA DE UN ESTER DE ACIDO MALONICO DE FORMULA NACH(COOR)2, DONDE R ES ALQUILO C 1 A 6, SEGUIDO DE LA HIDROGENOLISIS O HIDROLISIS DEL ESTER RESULTANTE, PARA OBTENER DERIVADOS DE ACIDO HEXAHIDRO-3,5-DIOXIDO,1H-PIRROLIZIN-2-CARBOXILICO DE FORMULA (I), DONDE A ES H, METILO, ALQUILO C 3 A 6 Y OTROS. SE UTILIZAN FARMACEUTICAMENTE PARA TRATAR LA SENILIDAD, PARA REFORZAR LA MEMORIA O DE INVERSION DE LA AMNESIA ELECTROCONVULSIVA INDUCIDA POR CHOQUE EN SERES HUMANOS.
ES535456A 1983-08-29 1984-08-28 Un metodo de preparar derivados de acido hexahidro-3,5-dioxo-1h-pirrolizino-2-carboxilico Granted ES535456A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/527,718 US4551470A (en) 1983-08-29 1983-08-29 Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia

Publications (2)

Publication Number Publication Date
ES8601996A1 true ES8601996A1 (es) 1985-11-16
ES535456A0 ES535456A0 (es) 1985-11-16

Family

ID=24102640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535456A Granted ES535456A0 (es) 1983-08-29 1984-08-28 Un metodo de preparar derivados de acido hexahidro-3,5-dioxo-1h-pirrolizino-2-carboxilico

Country Status (7)

Country Link
US (1) US4551470A (es)
EP (1) EP0136073A3 (es)
AU (1) AU565233B2 (es)
CA (1) CA1234121A (es)
DK (1) DK407984A (es)
ES (1) ES535456A0 (es)
GR (1) GR80225B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4638006A (en) * 1985-09-24 1987-01-20 Warner Lambert Company Amnesia reversal with N,N-dialkylaminoalkyl-hexahydro-5-oxo 1H-pyrrolizine-3-carboxamides
US4677098A (en) * 1985-11-22 1987-06-30 Warner-Lambert Company Substituted dihydro-1H-pyrolizine-3,5(2H,6H)-diones
US4663464A (en) * 1986-03-21 1987-05-05 Warner-Lambert Company Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4372966A (en) * 1980-09-15 1983-02-08 Warner-Lambert Company Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator
US4547519A (en) * 1982-05-24 1985-10-15 Warner-Lambert Company Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia

Also Published As

Publication number Publication date
AU565233B2 (en) 1987-09-10
CA1234121A (en) 1988-03-15
US4551470A (en) 1985-11-05
EP0136073A3 (en) 1987-03-25
DK407984D0 (da) 1984-08-27
EP0136073A2 (en) 1985-04-03
DK407984A (da) 1985-03-01
GR80225B (en) 1985-01-02
AU3232184A (en) 1985-03-07
ES535456A0 (es) 1985-11-16

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