ES8601985A1 - Procedimiento para la preparacion de 6-((ciclico amino) alquilamino)tetrahidrotriazolo (3,4-a)ftalazinas - Google Patents

Procedimiento para la preparacion de 6-((ciclico amino) alquilamino)tetrahidrotriazolo (3,4-a)ftalazinas

Info

Publication number
ES8601985A1
ES8601985A1 ES525368A ES525368A ES8601985A1 ES 8601985 A1 ES8601985 A1 ES 8601985A1 ES 525368 A ES525368 A ES 525368A ES 525368 A ES525368 A ES 525368A ES 8601985 A1 ES8601985 A1 ES 8601985A1
Authority
ES
Spain
Prior art keywords
cyclic amino
tetrahydrotriazolo
phthalazines
alkylamino
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525368A
Other languages
English (en)
Other versions
ES525368A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ES525368A0 publication Critical patent/ES525368A0/es
Publication of ES8601985A1 publication Critical patent/ES8601985A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 6-(CICLICO AMINO) ALQUILAMINO TETRAHIDROTRIAZOLO 3,4-A FTALAZINAS.COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA (III) EN EXCESO, CON UN DISOLVENTE ORGANICO INERTE, TAL COMO2-METOXIETANOL, A LA TEMPERATURA DE EBULLICION A REFLUJO, PARA OBTENER 6-(CICLICO AMINO) ALQUILAMINO TETRAHIDROTRIAZOLO 3,4-A FTALAZINAS DE FORMULA (I), O SUS SALES PREVIO TRATAMIENTO CON UN ACIDO ANHIDRIDO EN DISOLUCION DE ETANOL FARMACEUTICAMENTE ACEPTABLE. SIENDO: R, HIDROGENO O ALQUILO DE C 1 A 3; M ES 0 O 1; Y N ES 4 O 5; Y B) RECUPERAR EL PRODUCTO POR PROCEDIMIENTOS CONVENCIONALES O VERTIENDO LA MEZCLA DE LA REACCION EN AGUA DE HIELO.SE UTILIZA COMO BRONCODILATADOR PARA EL TRATAMIENTO DE DESORDENES COMO ASMA BRONQUIAL.
ES525368A 1982-09-07 1983-09-05 Procedimiento para la preparacion de 6-((ciclico amino) alquilamino)tetrahidrotriazolo (3,4-a)ftalazinas Expired ES8601985A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/414,766 US4487930A (en) 1982-09-07 1982-09-07 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines

Publications (2)

Publication Number Publication Date
ES525368A0 ES525368A0 (es) 1985-12-01
ES8601985A1 true ES8601985A1 (es) 1985-12-01

Family

ID=23642869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525368A Expired ES8601985A1 (es) 1982-09-07 1983-09-05 Procedimiento para la preparacion de 6-((ciclico amino) alquilamino)tetrahidrotriazolo (3,4-a)ftalazinas

Country Status (17)

Country Link
US (1) US4487930A (es)
EP (1) EP0104506B1 (es)
JP (1) JPS5965092A (es)
KR (1) KR880002685B1 (es)
AT (1) ATE23339T1 (es)
AU (1) AU555725B2 (es)
CA (1) CA1204753A (es)
DE (1) DE3367393D1 (es)
DK (1) DK160310C (es)
ES (1) ES8601985A1 (es)
GR (1) GR78970B (es)
IE (1) IE55908B1 (es)
IL (1) IL69659A (es)
NO (1) NO833181L (es)
NZ (1) NZ205493A (es)
PH (1) PH18334A (es)
ZA (1) ZA836551B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US5011835A (en) * 1990-02-07 1991-04-30 Merrell Dow Pharmaceuticals Inc. Substituted triazolopyridazines, pharmaceutical compositions and use
ATE236904T1 (de) 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren
US6989080B2 (en) * 2003-06-19 2006-01-24 Albany International Corp. Nonwoven neutral line dryer fabric
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA883836A (en) * 1971-10-19 H. De Ruiter Ernest Selective hydrogenation of tri- and tetrazoloisquinolines
US2484629A (en) * 1943-11-27 1949-10-11 Squibb & Sons Inc 2-sulfanilamido-4-alkoxymethyl-6-methyl-pyrimidines and their preparation
FR1248409A (fr) * 1957-06-13 1960-12-16 Bellon Labor Sa Roger Perfectionnements aux procédés de préparation de dérivés de la triazolo [4-3,b]pyridazine
US3096329A (en) * 1957-10-15 1963-07-02 Sterling Drug Inc Triazolo [b] pyridazines
US3079392A (en) * 1961-04-27 1963-02-26 Pesson Marcel Triazolo(4-3, b)pyridazines
NL128591C (es) * 1965-07-02
FR2068082A6 (es) * 1969-11-27 1971-08-20 Guinard Pompes
US3915968A (en) * 1973-09-21 1975-10-28 Lepetit Spa Triazolopyridazines
JPS5516450B2 (es) * 1974-08-16 1980-05-02
US4016162A (en) * 1974-08-27 1977-04-05 Gruppo Lepetit S.P.A. 6-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines
US4136182A (en) * 1976-05-26 1979-01-23 The Dow Chemical Company Triazolopyridazines used to alleviate bronchial spasms
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
US4272535A (en) * 1978-07-31 1981-06-09 Schering Corporation 2,4-[1H,3H,5H]-(1)-Benzopyrano-[2,3-d]-pyrimidinediones and their use as anti-allergy agents
GR70309B (es) * 1979-10-29 1982-09-08 Dow Chemical Co

Also Published As

Publication number Publication date
EP0104506B1 (en) 1986-11-05
JPH0378396B2 (es) 1991-12-13
NO833181L (no) 1984-03-08
PH18334A (en) 1985-06-05
IE832096L (en) 1984-03-07
GR78970B (es) 1984-10-02
DE3367393D1 (de) 1986-12-11
NZ205493A (en) 1985-09-13
AU1871383A (en) 1984-03-15
CA1204753A (en) 1986-05-20
KR840006247A (ko) 1984-11-22
DK160310C (da) 1991-07-29
IL69659A0 (en) 1983-12-30
IE55908B1 (en) 1991-02-14
DK160310B (da) 1991-02-25
JPS5965092A (ja) 1984-04-13
AU555725B2 (en) 1986-10-09
IL69659A (en) 1986-08-31
US4487930A (en) 1984-12-11
DK404383D0 (da) 1983-09-06
ES525368A0 (es) 1985-12-01
KR880002685B1 (ko) 1988-12-20
ZA836551B (en) 1984-04-25
EP0104506A1 (en) 1984-04-04
DK404383A (da) 1984-03-08
ATE23339T1 (de) 1986-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519