ES8600235A1 - Un procedimiento para sustituir un compuesto de acilamino-beta-lactama. - Google Patents

Un procedimiento para sustituir un compuesto de acilamino-beta-lactama.

Info

Publication number
ES8600235A1
ES8600235A1 ES528021A ES528021A ES8600235A1 ES 8600235 A1 ES8600235 A1 ES 8600235A1 ES 528021 A ES528021 A ES 528021A ES 528021 A ES528021 A ES 528021A ES 8600235 A1 ES8600235 A1 ES 8600235A1
Authority
ES
Spain
Prior art keywords
beta
group
preparation
acylamino
lactam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528021A
Other languages
English (en)
Other versions
ES528021A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES528021A0 publication Critical patent/ES528021A0/es
Publication of ES8600235A1 publication Critical patent/ES8600235A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE BBB-LACTAMA.COMPRENDE HACER REACCIONAR UNA BBB-LACTAMA DE FORMULA (II) CON UN AGENTE HALOGENANTE COMO HIPOCLORITO DE T-BUTILO, Y UN REACTIVO NUCLEOFILO, COMO UNA FUENTE DE UN RADICAL ALCOXI O ALQUILTIO, PARA OBTENER UN COMPUESTO DE BBB-LACTAMA DE FORMULA (I), DONDE A REPRESENTA UN SUSTITUYENTE Y X REPRESENTA UN GRUPO ACIDO. LA REACCION SE EFECTUA A BAJA TEMPERATURA COMO A MENOS DE 0JC, EN UN DISOLVENTE ANHIDRO EN EL QUE SON SOLUBLES LOS PRODUCTOS DE PARTIDA, COMO METANOL, ETANOL, DICLORURO DE METILO Y OTROS, Y DURANTE UN TIEMPO ENTRE 3 Y 10 MINUTOS, APAGANDO, DESPUES, LA MEZCLA DE REACCION POR ACIDULACION.SE EMPLEAN FARMACEUTICAMENTE POR SU ACTIVIDAD COMO AGENTES ANTIBACTERIANOS.
ES528021A 1982-12-14 1983-12-13 Un procedimiento para sustituir un compuesto de acilamino-beta-lactama. Expired ES8600235A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8235568 1982-12-14

Publications (2)

Publication Number Publication Date
ES528021A0 ES528021A0 (es) 1985-10-01
ES8600235A1 true ES8600235A1 (es) 1985-10-01

Family

ID=10534959

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528021A Expired ES8600235A1 (es) 1982-12-14 1983-12-13 Un procedimiento para sustituir un compuesto de acilamino-beta-lactama.

Country Status (12)

Country Link
US (1) US5750684A (es)
EP (1) EP0112049B1 (es)
JP (1) JPS59116289A (es)
AU (1) AU568105B2 (es)
CA (1) CA1267138A (es)
DE (1) DE3373475D1 (es)
ES (1) ES8600235A1 (es)
GR (1) GR79164B (es)
IE (1) IE56370B1 (es)
NZ (1) NZ206554A (es)
SG (1) SG70090G (es)
ZA (1) ZA839216B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416648D0 (en) * 1984-06-29 1984-08-01 Beecham Group Plc Chemical process
US6078501A (en) * 1997-12-22 2000-06-20 Omnirel Llc Power semiconductor module

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447602A (en) * 1971-11-29 1984-05-08 Merck & Co., Inc. Process to prepare 7-substituted cephalosporins or 6-substituted penicillins
YU36181B (en) * 1971-11-29 1982-02-25 Merck & Co Inc Process for obtaining 7-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylates
BE794554A (fr) * 1972-01-31 1973-07-26 Lilly Co Eli Nouveaux derives de penicilline et de cephalusporine
CA1040620A (en) * 1972-11-14 1978-10-17 Frank J. Urban 6-alkoxy-6-acylamidopenicillins 7-alkoxy-7-acylamido acetoxycephalosporins and process
JPS5095294A (es) * 1973-12-26 1975-07-29
US3960845A (en) * 1974-03-22 1976-06-01 Sankyo Company Limited Process for preparing 7β-acylamino-7α-alkoxycephalosporins or 6β-acylamino-6α-alkoxypenicillins
JPS609718B2 (ja) * 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質

Also Published As

Publication number Publication date
IE832916L (en) 1984-06-14
EP0112049B1 (en) 1987-09-09
ES528021A0 (es) 1985-10-01
EP0112049A1 (en) 1984-06-27
ZA839216B (en) 1984-09-26
NZ206554A (en) 1987-03-06
AU2231783A (en) 1984-06-21
SG70090G (en) 1990-10-26
GR79164B (es) 1984-10-02
US5750684A (en) 1998-05-12
CA1267138A (en) 1990-03-27
DE3373475D1 (en) 1987-10-15
JPS59116289A (ja) 1984-07-05
AU568105B2 (en) 1987-12-17
IE56370B1 (en) 1991-07-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050614