ES8507484A1 - Procedimiento de producir compuestos beta-lactamicos y similares - Google Patents
Procedimiento de producir compuestos beta-lactamicos y similaresInfo
- Publication number
- ES8507484A1 ES8507484A1 ES526759A ES526759A ES8507484A1 ES 8507484 A1 ES8507484 A1 ES 8507484A1 ES 526759 A ES526759 A ES 526759A ES 526759 A ES526759 A ES 526759A ES 8507484 A1 ES8507484 A1 ES 8507484A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- beta
- production
- protector
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Beta-lactam compounds Chemical class 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 230000001012 protector Effects 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- 239000002262 Schiff base Substances 0.000 abstract 1
- 150000004753 Schiff bases Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- YXFVVABEGXRONW-CNRUNOGKSA-N tritiomethylbenzene Chemical compound [3H]CC1=CC=CC=C1 YXFVVABEGXRONW-CNRUNOGKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR COMPUESTOS BETA-LACTAMICOS Y SIMILARES.CONSISTE EN HACER REACCIONAR UNA BASE DE SCHIFF FORMULA (II) CON UN DICETENO EN UN DISOLVENTE INERTE, COMO BENCENO O TOLUENO, EN PRESENCIA DE UN IMIDAZOL COMO 4-METILIMEDAZOL, EN UNA CANTIDAD DE 0,1 A 1,5 VECES LA MOLAR DE LA BASE SCHIFF, A UNA TEMPERATURA ENTRE C20 Y 120JC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R GRUPO PROTECTOR DEL GRUPO CARBOXILICO; R1 GRUP PROTECTOR DEL GRUPO CARBOXILICO O H; R2 GRUPO PROTECTOR DE UN ATOMO DE N; RA Y RB UN GRUPO OXO, O H Y OH RESPECTIVAMENTE SI R ES PROTECTOR DE UN GRUPO CARBOXILO O ES H.SE UTILIZAN EN LA SINTESIS DE DERIVADOS CARBAPENEMICOS O PENEMICOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57180268A JPS5970663A (ja) | 1982-10-13 | 1982-10-13 | β−ラクタム誘導体の製造法 |
JP57194894A JPS5970664A (ja) | 1982-11-06 | 1982-11-06 | 新規なβ−ラクタム化合物 |
JP58139068A JPS6032765A (ja) | 1983-07-28 | 1983-07-28 | β−ラクタム誘導体の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES526759A0 ES526759A0 (es) | 1985-10-01 |
ES8507484A1 true ES8507484A1 (es) | 1985-10-01 |
Family
ID=27317794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES526759A Expired ES8507484A1 (es) | 1982-10-13 | 1983-10-13 | Procedimiento de producir compuestos beta-lactamicos y similares |
Country Status (4)
Country | Link |
---|---|
US (1) | US4556514A (es) |
EP (1) | EP0106652B1 (es) |
DE (1) | DE3375481D1 (es) |
ES (1) | ES8507484A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1190236A (en) * | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Antibiotic synthesis |
JPS6118791A (ja) * | 1984-07-05 | 1986-01-27 | Kanegafuchi Chem Ind Co Ltd | 新規β−ラクタム化合物及びその製造法 |
US4791198A (en) * | 1984-07-05 | 1988-12-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Beta-lactam compound and preparation thereof |
US4861877A (en) * | 1984-07-05 | 1989-08-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one derivatives |
EP0171064B1 (en) * | 1984-08-06 | 1995-07-12 | Fujisawa Pharmaceutical Co., Ltd. | Azetidinone derivative and processes for production thereof |
GB8528380D0 (en) * | 1985-11-18 | 1985-12-24 | Ici Plc | Process |
CA1256444A (en) * | 1986-04-30 | 1989-06-27 | Kazunori Kan | Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives |
US5312914A (en) * | 1987-02-17 | 1994-05-17 | Ciba-Geigy Corp | Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone |
SG45180A1 (en) * | 1987-02-17 | 1998-01-16 | Ciba Geigy Ag | A process for the manufacture of 4-acetoxy-3- hydroxy-ethyl-azetidinone |
EP0290385B1 (de) * | 1987-05-04 | 1992-10-21 | Ciba-Geigy Ag | Neues Verfahren zur Herstellung von 4-Acyloxy-3-hydroxyethyl-azetidinonen |
US5274188A (en) * | 1987-05-04 | 1993-12-28 | Ciba-Geigy Corporation | Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones |
US5145957A (en) * | 1988-03-18 | 1992-09-08 | Merck & Co., Inc. | Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone |
US6180550B1 (en) | 1998-12-22 | 2001-01-30 | Mobile Oil Corporation | Small crystal ZSM-5, its synthesis and use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2404632A1 (fr) * | 1977-09-30 | 1979-04-27 | Kyowa Hakko Kogyo Kk | Nouveaux derives de l'azetidinone et leurs procedures de fabrication |
JPS55111463A (en) * | 1979-02-21 | 1980-08-28 | Sankyo Co Ltd | Beta-lactam compound and its preparation |
JPS56142259A (en) * | 1980-03-11 | 1981-11-06 | Sankyo Co Ltd | Beta-lactam compound and its preparation |
JPS5798257A (en) * | 1980-12-10 | 1982-06-18 | Sankyo Co Ltd | 3,4-disubstituted azetidine-2-one compound and its preparation |
EP0180252B1 (en) * | 1981-07-15 | 1989-04-26 | Sumitomo Pharmaceuticals Company, Limited | Process of preparing azetidinone compounds |
CA1190236A (en) * | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Antibiotic synthesis |
-
1983
- 1983-10-11 DE DE8383306146T patent/DE3375481D1/de not_active Expired
- 1983-10-11 EP EP83306146A patent/EP0106652B1/en not_active Expired
- 1983-10-13 ES ES526759A patent/ES8507484A1/es not_active Expired
- 1983-10-13 US US06/541,648 patent/US4556514A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES526759A0 (es) | 1985-10-01 |
EP0106652A1 (en) | 1984-04-25 |
DE3375481D1 (en) | 1988-03-03 |
EP0106652B1 (en) | 1988-01-27 |
US4556514A (en) | 1985-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980302 |