ES8506610A1 - Imidazolyl-methyl thio-ethyl guanidine deriv. - Google Patents

Imidazolyl-methyl thio-ethyl guanidine deriv.

Info

Publication number
ES8506610A1
ES8506610A1 ES532939A ES532939A ES8506610A1 ES 8506610 A1 ES8506610 A1 ES 8506610A1 ES 532939 A ES532939 A ES 532939A ES 532939 A ES532939 A ES 532939A ES 8506610 A1 ES8506610 A1 ES 8506610A1
Authority
ES
Spain
Prior art keywords
methyl
imidazolyl
reaction
methyl thio
methoxy benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532939A
Other languages
Spanish (es)
Other versions
ES532939A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Quimico Farmaceutica SA
Original Assignee
Union Quimico Farmaceutica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica SA filed Critical Union Quimico Farmaceutica SA
Priority to ES532939A priority Critical patent/ES8506610A1/en
Publication of ES532939A0 publication Critical patent/ES532939A0/en
Publication of ES8506610A1 publication Critical patent/ES8506610A1/en
Expired legal-status Critical Current

Links

Abstract

1-(4-methoxy benzoyl) 2-pyrrolidinone of formula (I) is made by reaction of 4-methoxy benzoyl chloride with methyl 4-amino butyrate hydrochloride at 15-100 deg.C and pH 2-3 with continuous agitation, to give 4-(4-methoxybenzoylamino)methyl. The organic phase is sepd., dried with sodium sulphate and the solvent removed by evapn. under vacuum. The residual oil is distilled under 0.05 mm. Hg pressure and cyclised during distn. at 140 deg.C. The reaction is carried out in presence of an acid acceptor, such as a carbonate, bicarbonate, alkali hydroxide or alkaline earth, pref. sodium carbonate, and the prod. is obtd. as a crystalline solid.
ES532939A 1984-05-30 1984-05-30 Imidazolyl-methyl thio-ethyl guanidine deriv. Expired ES8506610A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES532939A ES8506610A1 (en) 1984-05-30 1984-05-30 Imidazolyl-methyl thio-ethyl guanidine deriv.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES532939A ES8506610A1 (en) 1984-05-30 1984-05-30 Imidazolyl-methyl thio-ethyl guanidine deriv.

Publications (2)

Publication Number Publication Date
ES532939A0 ES532939A0 (en) 1985-08-01
ES8506610A1 true ES8506610A1 (en) 1985-08-01

Family

ID=8487416

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532939A Expired ES8506610A1 (en) 1984-05-30 1984-05-30 Imidazolyl-methyl thio-ethyl guanidine deriv.

Country Status (1)

Country Link
ES (1) ES8506610A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Also Published As

Publication number Publication date
ES532939A0 (en) 1985-08-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102