ES8506610A1 - Imidazolyl-methyl thio-ethyl guanidine deriv. - Google Patents
Imidazolyl-methyl thio-ethyl guanidine deriv.Info
- Publication number
- ES8506610A1 ES8506610A1 ES532939A ES532939A ES8506610A1 ES 8506610 A1 ES8506610 A1 ES 8506610A1 ES 532939 A ES532939 A ES 532939A ES 532939 A ES532939 A ES 532939A ES 8506610 A1 ES8506610 A1 ES 8506610A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- imidazolyl
- reaction
- methyl thio
- methoxy benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
1-(4-methoxy benzoyl) 2-pyrrolidinone of formula (I) is made by reaction of 4-methoxy benzoyl chloride with methyl 4-amino butyrate hydrochloride at 15-100 deg.C and pH 2-3 with continuous agitation, to give 4-(4-methoxybenzoylamino)methyl. The organic phase is sepd., dried with sodium sulphate and the solvent removed by evapn. under vacuum. The residual oil is distilled under 0.05 mm. Hg pressure and cyclised during distn. at 140 deg.C. The reaction is carried out in presence of an acid acceptor, such as a carbonate, bicarbonate, alkali hydroxide or alkaline earth, pref. sodium carbonate, and the prod. is obtd. as a crystalline solid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES532939A ES8506610A1 (en) | 1984-05-30 | 1984-05-30 | Imidazolyl-methyl thio-ethyl guanidine deriv. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES532939A ES8506610A1 (en) | 1984-05-30 | 1984-05-30 | Imidazolyl-methyl thio-ethyl guanidine deriv. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532939A0 ES532939A0 (en) | 1985-08-01 |
ES8506610A1 true ES8506610A1 (en) | 1985-08-01 |
Family
ID=8487416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532939A Expired ES8506610A1 (en) | 1984-05-30 | 1984-05-30 | Imidazolyl-methyl thio-ethyl guanidine deriv. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8506610A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
-
1984
- 1984-05-30 ES ES532939A patent/ES8506610A1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Also Published As
Publication number | Publication date |
---|---|
ES532939A0 (en) | 1985-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |