ES8506619A1 - Methoxy-benzoyl pyrrolidinone prepn. - Google Patents

Methoxy-benzoyl pyrrolidinone prepn.

Info

Publication number
ES8506619A1
ES8506619A1 ES536230A ES536230A ES8506619A1 ES 8506619 A1 ES8506619 A1 ES 8506619A1 ES 536230 A ES536230 A ES 536230A ES 536230 A ES536230 A ES 536230A ES 8506619 A1 ES8506619 A1 ES 8506619A1
Authority
ES
Spain
Prior art keywords
pyrrolidinone
distilled
effected
prepn
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536230A
Other languages
Spanish (es)
Other versions
ES536230A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA filed Critical Bioiberica SA
Priority to ES536230A priority Critical patent/ES8506619A1/en
Publication of ES536230A0 publication Critical patent/ES536230A0/en
Publication of ES8506619A1 publication Critical patent/ES8506619A1/en
Expired legal-status Critical Current

Links

Abstract

1-(4-Methoxybenzoyl)-2-pyrrolidinone is prepd. by first reacting 4-methoxybenzoyl chloride with the hydrochloride of methyl 4-aminobutyrate to obtain methyl 4-(4-methoxybenzoylamino) butyrate, at 15-100 deg.C under continuous stirring and at pH 2-3. The organic phase is sepd. and dried with sodium sulphate and the solvent is removed by evaporation under vacuum. The residue is distilled at a pressure of 0.05 mm Hg and a cyclisation reaction is effected at 140 deg.C in which the final prod., which is a crystalline solid, is distilled. The reaction is effected in the presence of an acid acceptor, such as an alkali or alkaline earth metal carbonate, hydrogen carbonate or hydroxide, pref. sodium carbonate.
ES536230A 1984-09-25 1984-09-25 Methoxy-benzoyl pyrrolidinone prepn. Expired ES8506619A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES536230A ES8506619A1 (en) 1984-09-25 1984-09-25 Methoxy-benzoyl pyrrolidinone prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES536230A ES8506619A1 (en) 1984-09-25 1984-09-25 Methoxy-benzoyl pyrrolidinone prepn.

Publications (2)

Publication Number Publication Date
ES536230A0 ES536230A0 (en) 1985-07-16
ES8506619A1 true ES8506619A1 (en) 1985-07-16

Family

ID=8487904

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536230A Expired ES8506619A1 (en) 1984-09-25 1984-09-25 Methoxy-benzoyl pyrrolidinone prepn.

Country Status (1)

Country Link
ES (1) ES8506619A1 (en)

Also Published As

Publication number Publication date
ES536230A0 (en) 1985-07-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519