ES8506619A1 - Methoxy-benzoyl pyrrolidinone prepn. - Google Patents
Methoxy-benzoyl pyrrolidinone prepn.Info
- Publication number
- ES8506619A1 ES8506619A1 ES536230A ES536230A ES8506619A1 ES 8506619 A1 ES8506619 A1 ES 8506619A1 ES 536230 A ES536230 A ES 536230A ES 536230 A ES536230 A ES 536230A ES 8506619 A1 ES8506619 A1 ES 8506619A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidinone
- distilled
- effected
- prepn
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
1-(4-Methoxybenzoyl)-2-pyrrolidinone is prepd. by first reacting 4-methoxybenzoyl chloride with the hydrochloride of methyl 4-aminobutyrate to obtain methyl 4-(4-methoxybenzoylamino) butyrate, at 15-100 deg.C under continuous stirring and at pH 2-3. The organic phase is sepd. and dried with sodium sulphate and the solvent is removed by evaporation under vacuum. The residue is distilled at a pressure of 0.05 mm Hg and a cyclisation reaction is effected at 140 deg.C in which the final prod., which is a crystalline solid, is distilled. The reaction is effected in the presence of an acid acceptor, such as an alkali or alkaline earth metal carbonate, hydrogen carbonate or hydroxide, pref. sodium carbonate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES536230A ES8506619A1 (en) | 1984-09-25 | 1984-09-25 | Methoxy-benzoyl pyrrolidinone prepn. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES536230A ES8506619A1 (en) | 1984-09-25 | 1984-09-25 | Methoxy-benzoyl pyrrolidinone prepn. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES536230A0 ES536230A0 (en) | 1985-07-16 |
ES8506619A1 true ES8506619A1 (en) | 1985-07-16 |
Family
ID=8487904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536230A Expired ES8506619A1 (en) | 1984-09-25 | 1984-09-25 | Methoxy-benzoyl pyrrolidinone prepn. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8506619A1 (en) |
-
1984
- 1984-09-25 ES ES536230A patent/ES8506619A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES536230A0 (en) | 1985-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |