ES8505991A1 - Di:hydro methyl oxo-pyridinyl nicotino-nitrile - Google Patents
Di:hydro methyl oxo-pyridinyl nicotino-nitrileInfo
- Publication number
- ES8505991A1 ES8505991A1 ES529977A ES529977A ES8505991A1 ES 8505991 A1 ES8505991 A1 ES 8505991A1 ES 529977 A ES529977 A ES 529977A ES 529977 A ES529977 A ES 529977A ES 8505991 A1 ES8505991 A1 ES 8505991A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridinyl
- nicotino
- nitrile
- methyl oxo
- hydro methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
1,2-Dihydro 6-methyl 2-ozo 5 -(4-pyridinyl)nicotinonitrile is made by reacting N,N-dimethylamino ethylene alononitrile with 4-pyridyl propanone in alcoholic solvent, pref. methyl alcohol, in presence of sodium alkoxide obtained in situ by dissolving metallic sodium in the alcohol. Reaction is at 50-70 deg. C for 4-6 hours. Prod. is isolated by removing part of the solvent in vacuum, pouring into cold water with stirring and filtering off for recrystallisation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES529977A ES8505991A1 (en) | 1984-02-23 | 1984-02-23 | Di:hydro methyl oxo-pyridinyl nicotino-nitrile |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES529977A ES8505991A1 (en) | 1984-02-23 | 1984-02-23 | Di:hydro methyl oxo-pyridinyl nicotino-nitrile |
Publications (2)
Publication Number | Publication Date |
---|---|
ES529977A0 ES529977A0 (en) | 1985-06-16 |
ES8505991A1 true ES8505991A1 (en) | 1985-06-16 |
Family
ID=8486924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529977A Expired ES8505991A1 (en) | 1984-02-23 | 1984-02-23 | Di:hydro methyl oxo-pyridinyl nicotino-nitrile |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8505991A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113493411A (en) * | 2020-03-20 | 2021-10-12 | 鲁南制药集团股份有限公司 | Method for synthesizing milrinone |
CN113493412A (en) * | 2020-03-20 | 2021-10-12 | 鲁南制药集团股份有限公司 | New process for preparing milrinone |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103664773A (en) * | 2013-12-18 | 2014-03-26 | 南京易亨制药有限公司 | Preparing method and refining method for milrinone |
-
1984
- 1984-02-23 ES ES529977A patent/ES8505991A1/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113493411A (en) * | 2020-03-20 | 2021-10-12 | 鲁南制药集团股份有限公司 | Method for synthesizing milrinone |
CN113493412A (en) * | 2020-03-20 | 2021-10-12 | 鲁南制药集团股份有限公司 | New process for preparing milrinone |
Also Published As
Publication number | Publication date |
---|---|
ES529977A0 (en) | 1985-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |