ES8505991A1 - Di:hydro methyl oxo-pyridinyl nicotino-nitrile - Google Patents

Di:hydro methyl oxo-pyridinyl nicotino-nitrile

Info

Publication number
ES8505991A1
ES8505991A1 ES529977A ES529977A ES8505991A1 ES 8505991 A1 ES8505991 A1 ES 8505991A1 ES 529977 A ES529977 A ES 529977A ES 529977 A ES529977 A ES 529977A ES 8505991 A1 ES8505991 A1 ES 8505991A1
Authority
ES
Spain
Prior art keywords
pyridinyl
nicotino
nitrile
methyl oxo
hydro methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529977A
Other languages
Spanish (es)
Other versions
ES529977A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Rubio SA
Original Assignee
Laboratorios Rubio SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Rubio SA filed Critical Laboratorios Rubio SA
Priority to ES529977A priority Critical patent/ES8505991A1/en
Publication of ES529977A0 publication Critical patent/ES529977A0/en
Publication of ES8505991A1 publication Critical patent/ES8505991A1/en
Expired legal-status Critical Current

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  • Pyridine Compounds (AREA)

Abstract

1,2-Dihydro 6-methyl 2-ozo 5 -(4-pyridinyl)nicotinonitrile is made by reacting N,N-dimethylamino ethylene alononitrile with 4-pyridyl propanone in alcoholic solvent, pref. methyl alcohol, in presence of sodium alkoxide obtained in situ by dissolving metallic sodium in the alcohol. Reaction is at 50-70 deg. C for 4-6 hours. Prod. is isolated by removing part of the solvent in vacuum, pouring into cold water with stirring and filtering off for recrystallisation.
ES529977A 1984-02-23 1984-02-23 Di:hydro methyl oxo-pyridinyl nicotino-nitrile Expired ES8505991A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES529977A ES8505991A1 (en) 1984-02-23 1984-02-23 Di:hydro methyl oxo-pyridinyl nicotino-nitrile

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES529977A ES8505991A1 (en) 1984-02-23 1984-02-23 Di:hydro methyl oxo-pyridinyl nicotino-nitrile

Publications (2)

Publication Number Publication Date
ES529977A0 ES529977A0 (en) 1985-06-16
ES8505991A1 true ES8505991A1 (en) 1985-06-16

Family

ID=8486924

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529977A Expired ES8505991A1 (en) 1984-02-23 1984-02-23 Di:hydro methyl oxo-pyridinyl nicotino-nitrile

Country Status (1)

Country Link
ES (1) ES8505991A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113493411A (en) * 2020-03-20 2021-10-12 鲁南制药集团股份有限公司 Method for synthesizing milrinone
CN113493412A (en) * 2020-03-20 2021-10-12 鲁南制药集团股份有限公司 New process for preparing milrinone

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664773A (en) * 2013-12-18 2014-03-26 南京易亨制药有限公司 Preparing method and refining method for milrinone

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113493411A (en) * 2020-03-20 2021-10-12 鲁南制药集团股份有限公司 Method for synthesizing milrinone
CN113493412A (en) * 2020-03-20 2021-10-12 鲁南制药集团股份有限公司 New process for preparing milrinone

Also Published As

Publication number Publication date
ES529977A0 (en) 1985-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519