ES8504803A1 - Un procedimiento para la preparacion de pirropirroles. - Google Patents

Un procedimiento para la preparacion de pirropirroles.

Info

Publication number
ES8504803A1
ES8504803A1 ES520076A ES520076A ES8504803A1 ES 8504803 A1 ES8504803 A1 ES 8504803A1 ES 520076 A ES520076 A ES 520076A ES 520076 A ES520076 A ES 520076A ES 8504803 A1 ES8504803 A1 ES 8504803A1
Authority
ES
Spain
Prior art keywords
alkyl
aroyl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520076A
Other languages
English (en)
Other versions
ES520076A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8504803A1 publication Critical patent/ES8504803A1/es
Publication of ES520076A0 publication Critical patent/ES520076A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRROLOPIRROLES.CONSISTE EN LA OXIDACION DE UN COMPUESTO DE FORMULA (II) EN DIMETILFORMAMIDA ACUOSA EN PRESENCIA DE CLORURO DE PALADIO Y CLORURO CUPROSO, CON OXIGENO PURO O AIRE, A TEMPERATURA AMBIENTE O LIGERAMENTE ELEVADA PARA OBTENER PIRROLOPIRROLES DE FORMULA (I), DONDE AR ES FENILO SUSTITUIDO EN POSICION ORTO, META O PARA CON ALQUILO C 1 A 4, ALCOXI C 1 A 4 Y OTROS; R1 ES H, ALQUILO C 1 A 4, FLUOR, BROMO O CLORO.TIENE ACTIVIDAD ANTIINFLAMATORIA Y ANALGESICA.
ES520076A 1982-02-25 1983-02-24 Un procedimiento para la preparacion de pirropirroles. Granted ES520076A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8205546 1982-02-25

Publications (2)

Publication Number Publication Date
ES8504803A1 true ES8504803A1 (es) 1985-05-01
ES520076A0 ES520076A0 (es) 1985-05-01

Family

ID=10528598

Family Applications (2)

Application Number Title Priority Date Filing Date
ES520076A Granted ES520076A0 (es) 1982-02-25 1983-02-24 Un procedimiento para la preparacion de pirropirroles.
ES526400A Expired ES8600292A1 (es) 1982-02-25 1983-10-11 Un procedimiento para la preparacion de pirrolopirroles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526400A Expired ES8600292A1 (es) 1982-02-25 1983-10-11 Un procedimiento para la preparacion de pirrolopirroles

Country Status (8)

Country Link
EP (1) EP0091181B1 (es)
JP (1) JPS58157789A (es)
AU (1) AU1176983A (es)
CA (1) CA1194026A (es)
DE (1) DE3368416D1 (es)
ES (2) ES520076A0 (es)
NZ (1) NZ203371A (es)
ZA (1) ZA831215B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US5260451A (en) * 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters

Also Published As

Publication number Publication date
DE3368416D1 (en) 1987-01-29
NZ203371A (en) 1986-05-09
ES526400A0 (es) 1985-10-01
ES520076A0 (es) 1985-05-01
ZA831215B (en) 1984-04-25
EP0091181A2 (en) 1983-10-12
JPS58157789A (ja) 1983-09-19
EP0091181B1 (en) 1986-12-17
CA1194026A (en) 1985-09-24
AU1176983A (en) 1983-09-01
EP0091181A3 (en) 1984-07-11
ES8600292A1 (es) 1985-10-01

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