ES8501373A1 - Procedimiento de preparacion de derivados de la sulfonilurea, asi como de sus sales de adicion correspondientes - Google Patents

Procedimiento de preparacion de derivados de la sulfonilurea, asi como de sus sales de adicion correspondientes

Info

Publication number
ES8501373A1
ES8501373A1 ES525920A ES525920A ES8501373A1 ES 8501373 A1 ES8501373 A1 ES 8501373A1 ES 525920 A ES525920 A ES 525920A ES 525920 A ES525920 A ES 525920A ES 8501373 A1 ES8501373 A1 ES 8501373A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525920A
Other languages
English (en)
Other versions
ES525920A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES525920A0 publication Critical patent/ES525920A0/es
Publication of ES8501373A1 publication Critical patent/ES8501373A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laminated Bodies (AREA)
  • Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE LA SULFONILUREA, ASI COMO DE SUS SALES DE ADICION CORRESPONDIENTES.CONSISTE EN, A) TRATAR LOS ACIDOS BENZOICOS DE FORMULA (II) CON SOCL2, PARA OBTENER LAS ISOBENZOFURANONAS DE FORMULA (III), B) CONDENSAR A (III) CON UN COMPUESTO DE FORMULA (IV), PARA OBTENER LAS 3-HIDROXI-ISO-INDOLONAS DE FORMULA (V), C) CONDENSAR A (V) CON UN COMPUESTO DE FORMULA RK4 -NFCFO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION CON AGENTES BASICOS. DONDE; N REPRESENTA 1 O 2; R REPRESENTA TIENILO, FURILO, PIRIDILO, Y OTROS; R1 Y R2 SON IDENTICOS O DIFERENTES Y REPRESENTAN HIDROGENO, HALOGENO, UN RADICAL ALCOILO O ALCOXI DE C 1 A 5; R4 ES RK4; RK4 REPRESENTA UN RADICAL ALCOILO DE C 1 A 5 O UN RADICAL CICLOALCOILO DE C 3 A 8 Y R3 ES OH.SE UTILIZAN COMO MEDICAMENTOS PARA EL TRATAMIENTO DE LA DIABETES.
ES525920A 1982-09-23 1983-09-23 Procedimiento de preparacion de derivados de la sulfonilurea, asi como de sus sales de adicion correspondientes Expired ES8501373A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8216012A FR2533563A1 (fr) 1982-09-23 1982-09-23 Nouveaux derives de la sulfonyluree, leurs procedes de preparation et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
ES525920A0 ES525920A0 (es) 1984-11-16
ES8501373A1 true ES8501373A1 (es) 1984-11-16

Family

ID=9277666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525920A Expired ES8501373A1 (es) 1982-09-23 1983-09-23 Procedimiento de preparacion de derivados de la sulfonilurea, asi como de sus sales de adicion correspondientes

Country Status (15)

Country Link
US (1) US4505921A (es)
EP (1) EP0109866B1 (es)
JP (1) JPS5980660A (es)
AT (1) ATE29026T1 (es)
AU (1) AU557000B2 (es)
CA (1) CA1213892A (es)
DE (1) DE3373094D1 (es)
DK (1) DK433583A (es)
ES (1) ES8501373A1 (es)
FR (1) FR2533563A1 (es)
IE (1) IE56004B1 (es)
NZ (1) NZ205700A (es)
OA (1) OA07536A (es)
PT (1) PT77374B (es)
ZA (1) ZA837055B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
DE3800577A1 (de) * 1988-01-12 1989-07-20 Basf Ag 3-(4-amino-2-hydroxyphenyl)-1-oxo-isoindolenine, verfahren zu deren herstellung und deren verseifung zu 2-(4-amino-2-hydroxybenzoyl)-benzoesaeuren
US5217970A (en) * 1989-06-26 1993-06-08 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
US5262413A (en) * 1989-06-26 1993-11-16 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
GB0419481D0 (en) * 2004-09-02 2004-10-06 Cancer Rec Tech Ltd Isoindolin-1-one derivatives
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
CA2806619C (en) * 2010-05-24 2018-05-22 Ozstar Therapeutics Pty Ltd Anti-diabetic compositions and methods
CN103880826B (zh) * 2013-12-10 2016-08-17 中山大学 一种异苯并呋喃酮化合物及其制备方法和应用
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU47776A1 (es) * 1964-07-30 1966-07-13
DE1445774A1 (de) * 1964-07-30 1969-01-23 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US3879418A (en) * 1970-09-22 1975-04-22 Sandoz Ag 1,1-Disubstituted-2-alkyl 3-oxo-isoindolines
DE2253251A1 (de) * 1972-10-30 1974-05-09 Thomae Gmbh Dr K Neue phthalimido-sulfonylharnstoffe

Also Published As

Publication number Publication date
EP0109866A1 (fr) 1984-05-30
ZA837055B (en) 1984-04-25
AU1935183A (en) 1984-03-29
IE832222L (en) 1984-03-23
DK433583D0 (da) 1983-09-22
AU557000B2 (en) 1986-11-27
FR2533563A1 (fr) 1984-03-30
ATE29026T1 (de) 1987-09-15
ES525920A0 (es) 1984-11-16
OA07536A (fr) 1985-03-31
PT77374B (fr) 1986-02-18
DK433583A (da) 1984-03-24
FR2533563B1 (es) 1985-05-24
CA1213892A (fr) 1986-11-12
PT77374A (fr) 1983-10-01
US4505921A (en) 1985-03-19
JPS5980660A (ja) 1984-05-10
IE56004B1 (en) 1991-03-13
DE3373094D1 (en) 1987-09-24
NZ205700A (en) 1986-06-11
EP0109866B1 (fr) 1987-08-19

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