ES8500887A1 - Un procedimiento para la preparacion de nuevos derivados de propanolamina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de propanolamina.Info
- Publication number
- ES8500887A1 ES8500887A1 ES523804A ES523804A ES8500887A1 ES 8500887 A1 ES8500887 A1 ES 8500887A1 ES 523804 A ES523804 A ES 523804A ES 523804 A ES523804 A ES 523804A ES 8500887 A1 ES8500887 A1 ES 8500887A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxypropylamine
- nr2coor1
- nr2so2r1
- ester derivatives
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PROPANOLAMINA.CONSISTE EN HACER REACCIONAR UNA AMINA DE FORMULA H2N-W-B CON GLICIDOL DE FORMULA (III) PARA PRODUCIR UN AMINODIOL DE FORMULA (III), Y HACER REACCIONAR EL AMINODIOL CON UN CLORURO DE ACILO DE FORMULA ARCOCL PARA PRODUCIR DERIVADOS DE PROPANOLAMINA DE FORMULA (I), Y POSTERIORMENTE ELIMINAR LOS GRUPOS PROTECTORES DE HIDROXILO, REDUCIR EL GRUPO NO2 A NH2 Y TRANSFORMAR EL PRODUCTO OBTENIDO EN UNA SAL ACEPTABLE, DONDE AR ES AROMATICO O HETEROCICLICO; W ES ALQUILENO DE C 1 A 10; B ES CNR2 COR1-NR2CONR1R3 Y OTROS; R1, R2 Y R3 SON HIDROGENO, ALQUILO Y OTROS.TIENEN APLICACION POR PRESENTAR ACTIVIDAD BLOQUEANTE BBB-ADRENERGICA Y SER UTILES EN EL TRATAMIENTO DE LA GLAUCOMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/320,773 US4582855A (en) | 1981-11-12 | 1981-11-12 | Aromatic and esters of hydroxypropylamines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES523804A0 ES523804A0 (es) | 1984-11-01 |
ES8500887A1 true ES8500887A1 (es) | 1984-11-01 |
Family
ID=23247815
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517296A Expired ES8401014A1 (es) | 1981-11-12 | 1982-11-11 | Un procedimiento para la preparacion de nuevos derivados de propanolamina. |
ES523805A Granted ES523805A0 (es) | 1981-11-12 | 1983-07-01 | Un procedimiento para la preparacion de nuevos derivados de propanolamina. |
ES523804A Expired ES8500887A1 (es) | 1981-11-12 | 1983-07-01 | Un procedimiento para la preparacion de nuevos derivados de propanolamina. |
ES530788A Granted ES530788A0 (es) | 1981-11-12 | 1984-03-20 | Un procedimiento para la preparacion de derivados de urea |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517296A Expired ES8401014A1 (es) | 1981-11-12 | 1982-11-11 | Un procedimiento para la preparacion de nuevos derivados de propanolamina. |
ES523805A Granted ES523805A0 (es) | 1981-11-12 | 1983-07-01 | Un procedimiento para la preparacion de nuevos derivados de propanolamina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530788A Granted ES530788A0 (es) | 1981-11-12 | 1984-03-20 | Un procedimiento para la preparacion de derivados de urea |
Country Status (14)
Country | Link |
---|---|
US (1) | US4582855A (es) |
EP (1) | EP0093765B1 (es) |
JP (2) | JPS6320424B1 (es) |
AU (1) | AU562862B2 (es) |
CA (1) | CA1201438A (es) |
DE (1) | DE3274640D1 (es) |
EG (1) | EG16198A (es) |
ES (4) | ES8401014A1 (es) |
GR (1) | GR78306B (es) |
IL (1) | IL67243A0 (es) |
IT (1) | IT1149118B (es) |
NZ (1) | NZ202228A (es) |
WO (1) | WO1983001770A1 (es) |
ZA (1) | ZA827749B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988007044A1 (en) * | 1987-03-17 | 1988-09-22 | Insite Vision, Inc. | Timolol derivatives |
JPH0662521B2 (ja) * | 1988-02-24 | 1994-08-17 | 日東紡績株式会社 | 新規コリン誘導体及びそれを用いた血清コリンエステラーゼ活性測定法 |
US4966914A (en) * | 1988-12-15 | 1990-10-30 | E. I. Du Pont De Nemours And Company | Oculoselective beta-blockers as antiglaucoma agents |
US5064827A (en) * | 1988-12-15 | 1991-11-12 | Du Pont Merck Pharmaceutical Company | Polyhydroxybenzyloxpropanolamines |
US4897417A (en) * | 1988-12-15 | 1990-01-30 | E. I. Du Pont De Nemours & Co. | Prodrugs of 3,4-hydroxy benzoyloxypropanolamines |
US4935422A (en) * | 1988-12-15 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Acyloxypropanolamines |
US5248808A (en) * | 1989-11-01 | 1993-09-28 | Avery Dennison Corporation | Vinyl functional reactive tackifiers for pressure-sensitive adhesives |
JPH04343212A (ja) * | 1991-05-20 | 1992-11-30 | Hitachi Aic Inc | ヒューズ付コンデンサ |
US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5543083A (en) * | 1994-07-26 | 1996-08-06 | The Procter & Gamble Company | Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation |
US5536749A (en) * | 1994-10-13 | 1996-07-16 | Sl Pharmaceuticals, Inc. | Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents |
CA2328124A1 (en) * | 1998-04-14 | 1999-10-21 | Samsung Fine Chemicals Co., Ltd. | A process for preparing chiral (s)-2,3-disubstituted-1-propylamine derivatives |
CA2713394C (en) * | 2007-11-09 | 2016-01-19 | Charles Yates | Anti-inflammatory quinic acid derivatives for oral administration |
EP2096105A1 (en) * | 2008-02-28 | 2009-09-02 | Laboratorios Almirall, S.A. | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1476934A (en) * | 1922-02-13 | 1923-12-11 | Abbott Lab | Anaesthetic compound |
US3129201A (en) * | 1959-10-30 | 1964-04-14 | Monsanto Chemicals | Alkyl 3-acyloxy-2-alkenoates and homopolymers thereof |
NL301580A (es) * | 1962-12-11 | |||
US4405642A (en) * | 1980-11-28 | 1983-09-20 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4387103A (en) * | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
-
1981
- 1981-11-12 US US06/320,773 patent/US4582855A/en not_active Expired - Lifetime
-
1982
- 1982-10-20 NZ NZ202228A patent/NZ202228A/en unknown
- 1982-10-22 ZA ZA827749A patent/ZA827749B/xx unknown
- 1982-10-28 WO PCT/US1982/001536 patent/WO1983001770A1/en active IP Right Grant
- 1982-10-28 AU AU10120/83A patent/AU562862B2/en not_active Ceased
- 1982-10-28 JP JP82503552A patent/JPS6320424B1/ja active Pending
- 1982-10-28 DE DE8282903569T patent/DE3274640D1/de not_active Expired
- 1982-10-28 EP EP82903569A patent/EP0093765B1/en not_active Expired
- 1982-10-28 JP JP57503552A patent/JPS58501724A/ja active Pending
- 1982-11-10 CA CA000415282A patent/CA1201438A/en not_active Expired
- 1982-11-10 GR GR69775A patent/GR78306B/el unknown
- 1982-11-11 ES ES517296A patent/ES8401014A1/es not_active Expired
- 1982-11-12 IL IL67243A patent/IL67243A0/xx not_active IP Right Cessation
- 1982-11-12 IT IT49477/82A patent/IT1149118B/it active
- 1982-11-13 EG EG671/82A patent/EG16198A/xx active
-
1983
- 1983-07-01 ES ES523805A patent/ES523805A0/es active Granted
- 1983-07-01 ES ES523804A patent/ES8500887A1/es not_active Expired
-
1984
- 1984-03-20 ES ES530788A patent/ES530788A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ES517296A0 (es) | 1983-12-01 |
CA1201438A (en) | 1986-03-04 |
JPS58501724A (ja) | 1983-10-13 |
IT8249477A0 (it) | 1982-11-12 |
ES8401014A1 (es) | 1983-12-01 |
EP0093765A4 (en) | 1984-04-27 |
US4582855A (en) | 1986-04-15 |
DE3274640D1 (de) | 1987-01-22 |
NZ202228A (en) | 1985-10-11 |
ES8500888A1 (es) | 1984-11-01 |
ES8505942A1 (es) | 1985-06-01 |
ES523804A0 (es) | 1984-11-01 |
IL67243A0 (en) | 1983-03-31 |
ES523805A0 (es) | 1984-11-01 |
ZA827749B (en) | 1983-08-31 |
IT1149118B (it) | 1986-12-03 |
EP0093765B1 (en) | 1986-12-10 |
GR78306B (es) | 1984-09-26 |
AU562862B2 (en) | 1987-06-18 |
WO1983001770A1 (en) | 1983-05-26 |
EG16198A (en) | 1987-09-30 |
ES530788A0 (es) | 1985-06-01 |
EP0093765A1 (en) | 1983-11-16 |
JPS6320424B1 (es) | 1988-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19891001 |