ES8406485A1 - Un procedimiento para la preparacion de quinolizidinil benzamidas. - Google Patents

Un procedimiento para la preparacion de quinolizidinil benzamidas.

Info

Publication number
ES8406485A1
ES8406485A1 ES521435A ES521435A ES8406485A1 ES 8406485 A1 ES8406485 A1 ES 8406485A1 ES 521435 A ES521435 A ES 521435A ES 521435 A ES521435 A ES 521435A ES 8406485 A1 ES8406485 A1 ES 8406485A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
substituted azabicyclo
xxiii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521435A
Other languages
English (en)
Other versions
ES521435A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8406485A1 publication Critical patent/ES8406485A1/es
Publication of ES521435A0 publication Critical patent/ES521435A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE QUINOLIZIDINIL BENZAMIDAS PUENTEADAS, DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE UN OXIDO DE LAS MISMAS Y DE SUS SOLVATOS, DE FORMULA (I), EN LA QUE P, Q Y J VALEN 0-2, 0-3 Y 0-4 RESPECTIVAMENTE; Y R5, R6 Y A PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA TQ1, CON UN COMPUESTO DE FORMULA (II) O DE FORMULA (III), EN LAS QUE Q6 ES NH2, Q7 ES HIDROGENO, T Y Q1 PUEDEN SER VARIOS RADICALES, J VALE 1-4, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I).
ES521435A 1982-04-14 1983-04-13 Un procedimiento para la preparacion de quinolizidinil benzamidas. Granted ES521435A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8210848 1982-04-14
GB8210847 1982-04-14

Publications (2)

Publication Number Publication Date
ES8406485A1 true ES8406485A1 (es) 1984-07-16
ES521435A0 ES521435A0 (es) 1984-07-16

Family

ID=26282551

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521435A Granted ES521435A0 (es) 1982-04-14 1983-04-13 Un procedimiento para la preparacion de quinolizidinil benzamidas.

Country Status (10)

Country Link
US (2) US4697019A (es)
EP (1) EP0094742B1 (es)
JP (2) JPH0647591B2 (es)
AU (1) AU563225B2 (es)
CA (1) CA1223873A (es)
DE (1) DE3381772D1 (es)
ES (1) ES521435A0 (es)
IE (1) IE56226B1 (es)
MY (1) MY100040A (es)
NZ (1) NZ203861A (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56226B1 (en) * 1982-04-14 1991-05-22 Beecham Group Plc Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
GB8515845D0 (en) * 1985-06-22 1985-07-24 Beecham Group Plc Treatment
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
EP0235878A3 (en) * 1986-01-16 1989-06-14 Beecham Group Plc Novel compounds
GB8607163D0 (en) * 1986-03-22 1986-04-30 Beecham Group Plc Chemical compound
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
EP0315390B1 (en) * 1987-11-04 1994-07-20 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines
US5110828A (en) * 1988-04-15 1992-05-05 Beecham Group P.L.C. Azabicyclo oxime derivatives
EP0363085A3 (en) 1988-10-03 1991-03-27 Beecham Group Plc Novel compounds
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
EP0392803B1 (en) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Novel compounds
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5223613A (en) * 1990-04-27 1993-06-29 G. D. Searle & Co. Azatetracycle compounds and process of preparing same
US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds
IE912974A1 (en) * 1990-08-24 1992-02-26 Beecham Group Plc Novel compounds
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
US5260303A (en) * 1991-03-07 1993-11-09 G. D. Searle & Co. Imidazopyridines as serotonergic 5-HT3 antagonists
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
AU1578692A (en) * 1991-03-07 1992-10-06 G.D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5234921A (en) * 1991-03-07 1993-08-10 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
US5227377A (en) * 1991-03-07 1993-07-13 G. D. Searle & Co. Meso-azacyclic amides of certain bicyclic carboxylic acids
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5219850A (en) * 1991-03-07 1993-06-15 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
US5244907A (en) * 1992-03-26 1993-09-14 A. H. Robins Company, Incorporated Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
US5468875A (en) * 1994-12-22 1995-11-21 American Home Products Corporation 1-azabicycloheptane derivatives
US6875774B2 (en) * 2002-08-06 2005-04-05 The University Of North Carolina Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands
GB0321091D0 (en) 2003-09-09 2003-10-08 Alizyme Therapeutics Ltd Synthesis
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
GB0329319D0 (en) * 2003-12-18 2004-01-21 Alizyme Therapeutics Ltd Synthesis
MX2010003375A (es) * 2007-10-01 2010-05-17 Comentis Inc Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor de acetilcolina alfa 7 nicotinico para el tratamiento de enfermedad de alzheimer.
TW201617342A (zh) 2014-07-11 2016-05-16 阿法馬根公司 調節α７活性之啶類

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182884A (en) * 1976-09-22 1980-01-08 Research Corporation Polycyclic chlorinated hydrocarbons containing bridgehead or imino nitrogen
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
IL61642A0 (en) * 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
EP0036269A1 (en) * 1980-03-15 1981-09-23 Beecham Group Plc Substituted benzamides
NZ197356A (en) * 1980-06-18 1984-05-31 Beecham Group Ltd Ar-alkylsulphinyl-n-(azaicycloalkyl(alkyl)) benzamides
IE56226B1 (en) * 1982-04-14 1991-05-22 Beecham Group Plc Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0094742B1 (en) 1990-08-01
EP0094742A3 (en) 1984-08-22
EP0094742A2 (en) 1983-11-23
US4697019A (en) 1987-09-29
US4857647A (en) 1989-08-15
IE56226B1 (en) 1991-05-22
MY100040A (en) 1989-06-29
AU1343483A (en) 1983-10-20
CA1223873A (en) 1987-07-07
IE830832L (en) 1983-10-14
NZ203861A (en) 1986-07-11
DE3381772D1 (de) 1990-09-06
JPH0714934B2 (ja) 1995-02-22
AU563225B2 (en) 1987-07-02
JPH0647591B2 (ja) 1994-06-22
JPH05194513A (ja) 1993-08-03
ES521435A0 (es) 1984-07-16
JPS58188885A (ja) 1983-11-04

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