ES8403115A1 - Process for the preparation of pyrimidinones and their acid addition salts - Google Patents

Process for the preparation of pyrimidinones and their acid addition salts

Info

Publication number
ES8403115A1
ES8403115A1 ES522898A ES522898A ES8403115A1 ES 8403115 A1 ES8403115 A1 ES 8403115A1 ES 522898 A ES522898 A ES 522898A ES 522898 A ES522898 A ES 522898A ES 8403115 A1 ES8403115 A1 ES 8403115A1
Authority
ES
Spain
Prior art keywords
group
pyrimidinones
preparation
denotes
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522898A
Other languages
Spanish (es)
Other versions
ES522898A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES522898A0 publication Critical patent/ES522898A0/en
Publication of ES8403115A1 publication Critical patent/ES8403115A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for the preparation of pyrimidinones of the general formula < IMAGE > in which A and B, together with the two carbon atoms lying in between, denote an optionally substituted phenyl ring or a pyridine ring, D denotes an alkylene or hydroxyalkylene group, R3 and R5 each denote a hydrogen atom or an alkyl group, R4 denotes a hydrogen atom or an alkoxy group and R6 denotes an alkyl group, or an alkylene or hydroxyalkylene group which is substituted at the end by an optionally substituted phenyl or phenoxy group, and their salts, which have useful pharmacological properties, in particular a hypotensive, antiarrhythmic and beta -receptor-blocking action.
ES522898A 1982-06-03 1983-06-01 Process for the preparation of pyrimidinones and their acid addition salts Expired ES8403115A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823220898 DE3220898A1 (en) 1982-06-03 1982-06-03 Process for the preparation of pyrimidinones and their acid addition salts

Publications (2)

Publication Number Publication Date
ES522898A0 ES522898A0 (en) 1984-03-01
ES8403115A1 true ES8403115A1 (en) 1984-03-01

Family

ID=6165198

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522898A Expired ES8403115A1 (en) 1982-06-03 1983-06-01 Process for the preparation of pyrimidinones and their acid addition salts
ES527906A Granted ES527906A0 (en) 1982-06-03 1983-12-09 PROCEDURE FOR THE PREPARATION OF PYRIMIDINONES (AS A DIVISIONAL OF PATENT NUMBER 522.898)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES527906A Granted ES527906A0 (en) 1982-06-03 1983-12-09 PROCEDURE FOR THE PREPARATION OF PYRIMIDINONES (AS A DIVISIONAL OF PATENT NUMBER 522.898)

Country Status (10)

Country Link
KR (1) KR840005107A (en)
CA (1) CA1217768A (en)
DD (1) DD210904A5 (en)
DE (1) DE3220898A1 (en)
DK (1) DK250883A (en)
ES (2) ES8403115A1 (en)
FI (1) FI831914L (en)
HU (1) HU190846B (en)
NO (1) NO831994L (en)
PT (1) PT76806B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
CN1518447A (en) * 2001-04-23 2004-08-04 �������Ǵ�ѧר������� Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic agents
JP2006512315A (en) * 2002-11-04 2006-04-13 エヌピーエス ファーマスーティカルズ インコーポレイテッド Quinazolinone compounds as calcilytics
EP1757594A4 (en) * 2004-05-31 2007-12-12 Banyu Pharma Co Ltd Quinazoline derivative
CN101531638B (en) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 Compound used as a regulator of estrogen-related receptor and applications thereof
CN101628913B (en) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 Compound as estrogen-related receptor modulator and application thereof

Also Published As

Publication number Publication date
ES8406450A1 (en) 1984-08-01
DD210904A5 (en) 1984-06-27
NO831994L (en) 1983-12-05
DK250883D0 (en) 1983-06-02
PT76806B (en) 1986-04-09
KR840005107A (en) 1984-11-03
DK250883A (en) 1983-12-04
FI831914L (en) 1983-12-04
DE3220898A1 (en) 1983-12-08
CA1217768A (en) 1987-02-10
ES522898A0 (en) 1984-03-01
HU190846B (en) 1986-11-28
ES527906A0 (en) 1984-08-01
PT76806A (en) 1983-07-01
FI831914A0 (en) 1983-05-30

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