ES8401974A1 - Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2). - Google Patents

Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2).

Info

Publication number
ES8401974A1
ES8401974A1 ES517500A ES517500A ES8401974A1 ES 8401974 A1 ES8401974 A1 ES 8401974A1 ES 517500 A ES517500 A ES 517500A ES 517500 A ES517500 A ES 517500A ES 8401974 A1 ES8401974 A1 ES 8401974A1
Authority
ES
Spain
Prior art keywords
complex
methylmorphinane
methoxy
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517500A
Other languages
English (en)
Other versions
ES517500A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodesfarma SA
Original Assignee
Prodes SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodes SA filed Critical Prodes SA
Priority to ES517500A priority Critical patent/ES8401974A1/es
Priority to US06/552,677 priority patent/US4514404A/en
Priority to AT83402220T priority patent/ATE40892T1/de
Priority to DE8383402220T priority patent/DE3379224D1/de
Priority to EP83402220A priority patent/EP0112739B1/en
Priority to JP58218560A priority patent/JPS59186984A/ja
Publication of ES517500A0 publication Critical patent/ES517500A0/es
Publication of ES8401974A1 publication Critical patent/ES8401974A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL COMPLEJO 3-METOXI-N-METILMORFINONA Y ACIDO TEOFILINACETICO (1:2), DE FORMULA (I).CONSISTE EN HACER REACCIONAR EN EL SENO DE UN DISOLVENTE APROPIADO 3-METOXI-N-METILMORFINANO CON ACIDO TEOFILINACETICO. COMO DISOLVENTES SE UTILIZAN DISOLVENTES POLARES TALES COMO ACETONITRILO E ISOBUTANOL. EL COMPLEJO OBTENIDO SE CRISTALIZA AL ENFRIAR LA MASA DE REACCION.
ES517500A 1982-11-19 1982-11-19 Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2). Expired ES8401974A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES517500A ES8401974A1 (es) 1982-11-19 1982-11-19 Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2).
US06/552,677 US4514404A (en) 1982-11-19 1983-11-17 Process for obtaining complex of 3-methoxy-N-methylmorphinan with 7-theophyllineacetic acid (1:2)
AT83402220T ATE40892T1 (de) 1982-11-19 1983-11-18 3-methoxy-n-methylmorphinan, theophyllinessigsaeure-(1:2)-komplex, verfahren zu ihrer herstellung und der komplex zur verwendung als arzneimittel.
DE8383402220T DE3379224D1 (en) 1982-11-19 1983-11-18 3-methoxy-n-methylmorphinane : theophyllinacetic acid (1:2) complex, process for preparing the same and said complex for therapeutical use
EP83402220A EP0112739B1 (en) 1982-11-19 1983-11-18 3-methoxy-n-methylmorphinane : theophyllinacetic acid (1:2) complex, process for preparing the same and said complex for therapeutical use
JP58218560A JPS59186984A (ja) 1982-11-19 1983-11-19 ３−メトキシ−ｎ−メチルモルフイナンとテオフイリン酢酸との複合体およびその製造法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES517500A ES8401974A1 (es) 1982-11-19 1982-11-19 Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2).

Publications (2)

Publication Number Publication Date
ES517500A0 ES517500A0 (es) 1984-01-01
ES8401974A1 true ES8401974A1 (es) 1984-01-01

Family

ID=8484941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517500A Expired ES8401974A1 (es) 1982-11-19 1982-11-19 Procedimiento para la obtencion del complejo 3-metoxi-n-metilmorfinona y acido teofilinacetico (1:2).

Country Status (6)

Country Link
US (1) US4514404A (es)
EP (1) EP0112739B1 (es)
JP (1) JPS59186984A (es)
AT (1) ATE40892T1 (es)
DE (1) DE3379224D1 (es)
ES (1) ES8401974A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676177A (en) * 1949-11-09 1954-04-20 Hoffmann La Roche Process for the preparation of optically active 3-methoxy-n-methyl morphinans and salts thereof
GB933141A (en) * 1960-09-19 1963-08-08 Miles Lab Dextromethorphan n-cyclohexylsulphamate
GB1060245A (es) * 1963-04-26
FR3748M (fr) * 1964-06-18 1965-12-13 Sobio Lab Compositions thérapeutiques antitussives, anti-inflammatoires et bronchodilatatrices a base de sels nouveaux des acides : 2,6-di-ter-butyl-naphtalene mono et di-sulfonique, et de l'acide théophyllinyl-7-acétique.
US3466277A (en) * 1966-12-13 1969-09-09 Boehringer Sohn Ingelheim N-allylic cyclohexyl lower alkyl normorphines
FR7348M (es) * 1967-12-07 1969-10-13

Also Published As

Publication number Publication date
EP0112739A1 (en) 1984-07-04
EP0112739B1 (en) 1989-02-22
ES517500A0 (es) 1984-01-01
DE3379224D1 (en) 1989-03-30
US4514404A (en) 1985-04-30
JPS59186984A (ja) 1984-10-23
JPS6233234B2 (es) 1987-07-20
ATE40892T1 (de) 1989-03-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009