ES8401029A1 - Procedimiento para la obtencion de acido 1-(4-clorobenzoil)-5-metoxi-2-metil-3-indolacetoxiacetico. - Google Patents

Procedimiento para la obtencion de acido 1-(4-clorobenzoil)-5-metoxi-2-metil-3-indolacetoxiacetico.

Info

Publication number
ES8401029A1
ES8401029A1 ES520124A ES520124A ES8401029A1 ES 8401029 A1 ES8401029 A1 ES 8401029A1 ES 520124 A ES520124 A ES 520124A ES 520124 A ES520124 A ES 520124A ES 8401029 A1 ES8401029 A1 ES 8401029A1
Authority
ES
Spain
Prior art keywords
methoxy
methyl
preparation
indolylacetoxy
chlorbenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520124A
Other languages
English (en)
Other versions
ES520124A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Publication of ES520124A0 publication Critical patent/ES520124A0/es
Publication of ES8401029A1 publication Critical patent/ES8401029A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDO 1-(4-CLOROBENZOIL)-5-METOXI-2-METIL-3-INDOLACETOXIACETICO .CONSISTE EN HACER REACCIONAR ACIDO INDOLCARBOXILICO O SUS DERIVADOS DE FORMULA GENERAL (I), CON COMPUESTOS DE FORMULA GENERAL (II), EN LA QUE R SIGNIFICA HIDROGENO O AMONIUM, EN PRESENCIA DE DISOLVENTES ORGANICOS INERTES, EN UN MARGEN DE TEMPERATURAS COMPRENDIDO ENTRE C10 GRADOS Y 80 GRADOS. COMO DISOLVENTES ORGANICOS INERTES SE EMPLEAN ETERES, DIETILETER, DIISOPROPILETER, DIOXANO, TETRAHIDROFURANO, 1,2-DIMETOXIETANO, HIDROCARBUROS CLORADOS, CLORURO METILENICO, CLOROFORMO Y SIMILARES.DE APLICACIONEN FARMACIA POR SU EFICACIA ANTIFLOGISTICA.
ES520124A 1982-02-26 1983-02-25 Procedimiento para la obtencion de acido 1-(4-clorobenzoil)-5-metoxi-2-metil-3-indolacetoxiacetico. Expired ES8401029A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823206889 DE3206889A1 (de) 1982-02-26 1982-02-26 Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure

Publications (2)

Publication Number Publication Date
ES520124A0 ES520124A0 (es) 1983-12-01
ES8401029A1 true ES8401029A1 (es) 1983-12-01

Family

ID=6156734

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520124A Expired ES8401029A1 (es) 1982-02-26 1983-02-25 Procedimiento para la obtencion de acido 1-(4-clorobenzoil)-5-metoxi-2-metil-3-indolacetoxiacetico.

Country Status (8)

Country Link
US (1) US4585880A (es)
EP (1) EP0087654B1 (es)
JP (1) JPS58164574A (es)
AT (1) ATE19511T1 (es)
DE (2) DE3206889A1 (es)
ES (1) ES8401029A1 (es)
GR (1) GR78119B (es)
PT (1) PT76240A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416895A1 (de) * 1984-05-08 1985-11-14 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acemetacin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2518456A (en) * 1946-04-19 1950-08-15 Martin L Fein Preparation of acyloxy carboxylic acids from esters of hydroxy carboxylic acids
GB1131545A (en) * 1966-04-22 1968-10-23 Dumex Ltd As Indole derivatives
CS190723B1 (en) * 1976-06-30 1979-06-29 Ludmila Fisnerova 2-phenyl-2-carboxyethylester of 1-/p-chlorbenzoyl/-5-methoxy-2-methyl-3-indolyl acetic acid and method of producing the same
DE2740854A1 (de) * 1977-09-10 1979-03-29 Troponwerke Gmbh & Co Kg Neue substituierte 3-indolacetoxyalkansulfonsaeuresalze, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE2943125A1 (de) * 1979-10-25 1981-05-14 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indol acetoxyessigsaeure

Also Published As

Publication number Publication date
ATE19511T1 (de) 1986-05-15
EP0087654A1 (de) 1983-09-07
DE3206889A1 (de) 1983-09-15
ES520124A0 (es) 1983-12-01
US4585880A (en) 1986-04-29
EP0087654B1 (de) 1986-04-30
GR78119B (es) 1984-09-26
DE3363239D1 (en) 1986-06-05
JPH0254827B2 (es) 1990-11-22
PT76240A (en) 1983-03-01
JPS58164574A (ja) 1983-09-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603