ES8400431A1 - Procedimiento para preparar nuevas 1-(3-(6-fluoro-1,2-bencisoxazol-3-il)propil)piperazinas y piperidinas. - Google Patents

Procedimiento para preparar nuevas 1-(3-(6-fluoro-1,2-bencisoxazol-3-il)propil)piperazinas y piperidinas.

Info

Publication number
ES8400431A1
ES8400431A1 ES516830A ES516830A ES8400431A1 ES 8400431 A1 ES8400431 A1 ES 8400431A1 ES 516830 A ES516830 A ES 516830A ES 516830 A ES516830 A ES 516830A ES 8400431 A1 ES8400431 A1 ES 8400431A1
Authority
ES
Spain
Prior art keywords
benzisoxazol
piperazines
piperidines
fluoro
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516830A
Other languages
English (en)
Other versions
ES516830A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/366,244 external-priority patent/US4390544A/en
Priority claimed from US06/366,248 external-priority patent/US4536578A/en
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES516830A0 publication Critical patent/ES516830A0/es
Publication of ES8400431A1 publication Critical patent/ES8400431A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS 1-(3-(6-FLUORO-1,2-BEN CISOXAZOL-3-IL) PROPIL) PIPERACINAS Y PIPERIDINAS.SE HACE REACCIONAR EL COMPUESTO (II) CON EL COMPUESTO (III) EN PRESENCIA DE UN ACEPTOR DE ACIDO, EN PROMOTOR DE DESPLAZAMIENTO Y UN DISOLVENTE A TEMPERATURAS COMPRENDIDAS ENTRE 50 Y 130JC. EL ACEPTOR EMPLEADO ES UN CARBONATO O BICARBONATO DE METAL ALCALINO, EL PROMOTOR ES UN HALURO DE METAL ALCALINO Y EL DISOLVENTE ES UN COMPUESTO APROTICO POLAR. SE OTIENE EL COMPUESTO (I) EN QUE R ES EL COMPUESTO (IV), SIENDO R, ALCOHILO INFERIOR, BENCILO, 2-HIDROXIETILO, PIRIDILO O FENILO.
ES516830A 1982-04-09 1982-10-26 Procedimiento para preparar nuevas 1-(3-(6-fluoro-1,2-bencisoxazol-3-il)propil)piperazinas y piperidinas. Expired ES8400431A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/366,244 US4390544A (en) 1982-04-09 1982-04-09 {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p
US06/366,248 US4536578A (en) 1982-04-09 1982-04-09 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines

Publications (2)

Publication Number Publication Date
ES516830A0 ES516830A0 (es) 1983-10-16
ES8400431A1 true ES8400431A1 (es) 1983-10-16

Family

ID=27003274

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516830A Expired ES8400431A1 (es) 1982-04-09 1982-10-26 Procedimiento para preparar nuevas 1-(3-(6-fluoro-1,2-bencisoxazol-3-il)propil)piperazinas y piperidinas.

Country Status (16)

Country Link
EP (1) EP0091511B1 (es)
KR (1) KR880002013B1 (es)
AT (1) ATE34170T1 (es)
CA (1) CA1209146A (es)
DE (1) DE3278471D1 (es)
DK (1) DK474382A (es)
ES (1) ES8400431A1 (es)
FI (1) FI823433L (es)
GR (1) GR77706B (es)
HU (1) HU191075B (es)
IE (1) IE54065B1 (es)
IL (1) IL66866A (es)
NO (1) NO823556L (es)
NZ (1) NZ202044A (es)
PH (1) PH18252A (es)
PT (1) PT75726A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
US5055476A (en) * 1990-08-13 1991-10-08 Hoechst-Roussel Pharmaceuticals Incorporated 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
UA45944C2 (uk) * 1991-03-28 2002-05-15 Ейсай Ко., Лтд Гетероцикло-циклічні похідні амінів або їх фармацевтично прийнятні солі, проміжні сполуки, фармацевтична композиція, спосіб інгібування холінестерази, спосіб одержання гетероцикло-циклічних похідних амінів
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
US5225412A (en) * 1991-04-29 1993-07-06 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
KR102210789B1 (ko) * 2012-12-19 2021-02-01 헨켈 아게 운트 코. 카게아아 부품들의 소음 감쇠 및 방음 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI60390C (fi) * 1975-03-05 1982-01-11 Sumitomo Chemical Co Foerfarande foer framstaellning av neuroleptiska butyrofenoner
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
IL66866A0 (en) 1982-12-31
KR880002013B1 (ko) 1988-10-12
HU191075B (en) 1987-01-28
KR840001974A (ko) 1984-06-07
EP0091511A3 (en) 1984-12-12
ATE34170T1 (de) 1988-05-15
NZ202044A (en) 1987-04-30
EP0091511B1 (en) 1988-05-11
EP0091511A2 (en) 1983-10-19
DK474382A (da) 1983-10-10
IL66866A (en) 1987-08-31
ES516830A0 (es) 1983-10-16
IE822558L (en) 1983-10-09
PT75726A (en) 1982-11-01
NO823556L (no) 1983-10-10
CA1209146A (en) 1986-08-05
DE3278471D1 (en) 1988-06-16
FI823433L (fi) 1983-10-10
FI823433A0 (fi) 1982-10-08
GR77706B (es) 1984-09-25
PH18252A (en) 1985-05-13
IE54065B1 (en) 1989-06-07

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