ES8307894A1 - Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables. - Google Patents
Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables.Info
- Publication number
- ES8307894A1 ES8307894A1 ES517485A ES517485A ES8307894A1 ES 8307894 A1 ES8307894 A1 ES 8307894A1 ES 517485 A ES517485 A ES 517485A ES 517485 A ES517485 A ES 517485A ES 8307894 A1 ES8307894 A1 ES 8307894A1
- Authority
- ES
- Spain
- Prior art keywords
- antibiotics
- isolation
- chemically unstable
- fermentation solutions
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000855 fermentation Methods 0.000 title abstract 3
- 230000004151 fermentation Effects 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA AISLAR ANTIBIOTICOS DE CARBAPENEM, QUIMICAMENTE INESTABLES, A PARTIR DE SOLUCIONES DE FERMENTACION. CARACTERIZADO PORQUE LOS ANTIBIOTICOS FORMADOS SE ADSORBEN EN ADECUADAS RESINAS INTERCAMBIADORAS DE IONES, AL OBJETO DE CONVERTIRLOS EN UNA FORMA ESTABILIZADA; PORQUE COMO RESINA INTERCAMBIADORA DE IONES SE EMPLEAN INTERCAMBIADORES DE ANIONES CON BASIDAD DESDE MEDIA HASTA FUERTE; PORQUE LA RESINA INTERCAMBIADORA DE IONES SE AÑADE EN EL MOMENTO OPORTUNO A LA SOLUCION DE FERMENTACION Y ESTA SE ENFRIA RAPIDAMENTE; Y PORQUE LOS INTERCAMBIADORES DE ANIONES SE SEPARAN DE LA SOLUCION DE FERMENTACION POR FILTRACION A TRAVES DE UN TAMIZ ADECUADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813146190 DE3146190A1 (de) | 1981-11-21 | 1981-11-21 | Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8307894A1 true ES8307894A1 (es) | 1983-08-01 |
ES517485A0 ES517485A0 (es) | 1983-08-01 |
Family
ID=6146895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517485A Granted ES517485A0 (es) | 1981-11-21 | 1982-11-19 | Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4529545A (es) |
EP (1) | EP0080166B1 (es) |
JP (1) | JPS58101696A (es) |
AT (1) | ATE15227T1 (es) |
CA (1) | CA1199885A (es) |
DE (2) | DE3146190A1 (es) |
ES (1) | ES517485A0 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3973015A (en) * | 1970-08-03 | 1976-08-03 | Eli Lilly And Company | Antibiotic A16884 |
US4054564A (en) * | 1970-08-03 | 1977-10-18 | Eli Lilly And Company | 7-(5-Amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid |
US3962427A (en) * | 1972-12-08 | 1976-06-08 | Eli Lilly And Company | Antibiotic nebramycin factor VII |
US4000161A (en) * | 1974-12-19 | 1976-12-28 | Merck & Co., Inc. | Process for purifying thienamycin |
US3993748A (en) * | 1975-01-20 | 1976-11-23 | The Upjohn Company | Antibiotic U-47,929 and its preparation |
DE2528622A1 (de) * | 1975-06-26 | 1977-01-13 | Bayer Ag | Verfahren zur reinigung der bei der enzymatischen spaltung von beta-lactam- antibiotika anfallenden produkte |
US4229534A (en) * | 1975-11-21 | 1980-10-21 | Merck & Co., Inc. | Acetylthienamycin production |
US4282322A (en) * | 1975-11-24 | 1981-08-04 | Merck & Co., Inc. | Process for enzymatic deacylation of antibiotics |
DK497476A (da) * | 1975-11-24 | 1977-05-25 | Merck & Co Inc | Fremgangsmade til fremstilling af et antibiotisk stof |
SE7801695L (sv) * | 1977-03-01 | 1978-09-02 | Merck & Co Inc | Tienamycin |
GR62185B (en) * | 1977-03-31 | 1979-03-02 | Panlabs Inc | Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase |
GB1583841A (en) * | 1977-07-14 | 1981-02-04 | Beecham Group Ltd | Antibiotics mm4550 mm13902 and mm17880 preparation |
JPS55136282A (en) * | 1979-04-06 | 1980-10-23 | Shionogi & Co Ltd | Novel antibiotic pa-31088-4 |
US4247640A (en) * | 1979-07-23 | 1981-01-27 | Merck & Co., Inc. | Fermentation process for 6-hydroxymethyl-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid |
ATE4224T1 (de) * | 1979-08-28 | 1983-08-15 | Merck & Co. Inc. | Verfahren zur reinigung von thienamycin. |
KR840001256B1 (ko) * | 1980-08-19 | 1984-09-01 | 메이지세카 주식회사 | 신항생물질 sf-2103a 물질의 제조법 |
-
1981
- 1981-11-21 DE DE19813146190 patent/DE3146190A1/de not_active Withdrawn
-
1982
- 1982-11-18 AT AT82110641T patent/ATE15227T1/de not_active IP Right Cessation
- 1982-11-18 EP EP82110641A patent/EP0080166B1/de not_active Expired
- 1982-11-18 DE DE8282110641T patent/DE3265895D1/de not_active Expired
- 1982-11-19 US US06/443,130 patent/US4529545A/en not_active Expired - Fee Related
- 1982-11-19 ES ES517485A patent/ES517485A0/es active Granted
- 1982-11-19 JP JP57202235A patent/JPS58101696A/ja active Pending
- 1982-11-19 CA CA000415971A patent/CA1199885A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0080166B1 (de) | 1985-08-28 |
DE3146190A1 (de) | 1983-06-16 |
DE3265895D1 (en) | 1985-10-03 |
CA1199885A (en) | 1986-01-28 |
EP0080166A1 (de) | 1983-06-01 |
ES517485A0 (es) | 1983-08-01 |
US4529545A (en) | 1985-07-16 |
ATE15227T1 (de) | 1985-09-15 |
JPS58101696A (ja) | 1983-06-16 |
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