ES8307216A1 - Proline derivatives and process for producing the same - Google Patents

Proline derivatives and process for producing the same

Info

Publication number
ES8307216A1
ES8307216A1 ES513277A ES513277A ES8307216A1 ES 8307216 A1 ES8307216 A1 ES 8307216A1 ES 513277 A ES513277 A ES 513277A ES 513277 A ES513277 A ES 513277A ES 8307216 A1 ES8307216 A1 ES 8307216A1
Authority
ES
Spain
Prior art keywords
proline derivatives
producing
group
same
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513277A
Other languages
Spanish (es)
Other versions
ES513277A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56094002A external-priority patent/JPS57209270A/en
Priority claimed from JP56137823A external-priority patent/JPS5839661A/en
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of ES513277A0 publication Critical patent/ES513277A0/en
Publication of ES8307216A1 publication Critical patent/ES8307216A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Proline derivatives of the formula (I): < IMAGE > (wherein R is an acyl group bonded to the alpha -amino group of amino acid A and is selected from the group consisting of cyclopropanecarbonyl, cyclohexanecarbonyl and adamantanecarbonyl groups A is glycine, sarcosine or alpha -D-amino acid residue the carbonyl group of which forms a thiol ester bond with the sulfur atom) or a pharmaceutically acceptable salt thereof, and a process for producing the same are disclosed. The proline derivatives are useful for treating hypertension due to angiotensin II, and as an agent to treat cardiac insufficiency.
ES513277A 1981-06-19 1982-06-18 Proline derivatives and process for producing the same Expired ES8307216A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56094002A JPS57209270A (en) 1981-06-19 1981-06-19 Proline derivative
JP56137823A JPS5839661A (en) 1981-09-03 1981-09-03 Preparation of proline derivative

Publications (2)

Publication Number Publication Date
ES513277A0 ES513277A0 (en) 1983-07-01
ES8307216A1 true ES8307216A1 (en) 1983-07-01

Family

ID=26435270

Family Applications (2)

Application Number Title Priority Date Filing Date
ES513277A Expired ES8307216A1 (en) 1981-06-19 1982-06-18 Proline derivatives and process for producing the same
ES520582A Expired ES8403868A1 (en) 1981-06-19 1983-03-14 Proline derivatives and process for producing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES520582A Expired ES8403868A1 (en) 1981-06-19 1983-03-14 Proline derivatives and process for producing the same

Country Status (19)

Country Link
KR (1) KR890000769B1 (en)
AT (1) AT377496B (en)
CA (1) CA1235120A (en)
CH (1) CH651825A5 (en)
DE (1) DE3222779A1 (en)
DK (1) DK156054C (en)
ES (2) ES8307216A1 (en)
FI (1) FI75804C (en)
FR (1) FR2508040B1 (en)
GB (1) GB2102412B (en)
HU (1) HU188177B (en)
IL (1) IL65954A (en)
IT (1) IT1157053B (en)
MX (2) MX155724A (en)
NL (1) NL193282C (en)
NO (1) NO156408C (en)
PT (1) PT75076B (en)
SE (1) SE453595B (en)
SU (1) SU1316556A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (en) * 1985-03-27 1988-03-08 Ajinomoto Co Inc Blood sugar lowering agent
KR870007114A (en) * 1986-01-21 1987-08-14 우에노 기미오 Stable Solid Agents of Thiol Ester Derivatives
ZA896851B (en) 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors
EP0634175B1 (en) * 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids

Also Published As

Publication number Publication date
ATA558581A (en) 1984-08-15
DE3222779A1 (en) 1983-01-27
MX155724A (en) 1988-04-20
GB2102412A (en) 1983-02-02
PT75076B (en) 1984-05-09
CA1235120A (en) 1988-04-12
ES513277A0 (en) 1983-07-01
FI822171A0 (en) 1982-06-16
NL193282C (en) 1999-05-06
DK156054C (en) 1989-11-06
ES520582A0 (en) 1984-04-01
DE3222779C2 (en) 1991-01-03
SE8203814L (en) 1982-12-20
NO821997L (en) 1982-12-20
MX171888B (en) 1993-11-23
CH651825A5 (en) 1985-10-15
IT1157053B (en) 1987-02-11
ES8403868A1 (en) 1984-04-01
GB2102412B (en) 1985-01-09
NO156408B (en) 1987-06-09
IL65954A (en) 1986-03-31
FR2508040B1 (en) 1986-07-04
DK156054B (en) 1989-06-19
FI822171L (en) 1982-12-20
IL65954A0 (en) 1982-09-30
FR2508040A1 (en) 1982-12-24
NO156408C (en) 1987-09-16
SE453595B (en) 1988-02-15
PT75076A (en) 1982-07-01
FI75804B (en) 1988-04-29
HU188177B (en) 1986-03-28
DK273082A (en) 1982-12-20
KR840000488A (en) 1984-02-22
SU1316556A3 (en) 1987-06-07
IT8267772A0 (en) 1982-06-16
NL193282B (en) 1999-01-04
NL8202472A (en) 1983-01-17
AT377496B (en) 1985-03-25
FI75804C (en) 1988-08-08
KR890000769B1 (en) 1989-04-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401