ES8306712A1 - Un procedimiento para la preparacion de derivados de aminoacidos utiles como agentes antihipertensores. - Google Patents

Un procedimiento para la preparacion de derivados de aminoacidos utiles como agentes antihipertensores.

Info

Publication number
ES8306712A1
ES8306712A1 ES505545A ES505545A ES8306712A1 ES 8306712 A1 ES8306712 A1 ES 8306712A1 ES 505545 A ES505545 A ES 505545A ES 505545 A ES505545 A ES 505545A ES 8306712 A1 ES8306712 A1 ES 8306712A1
Authority
ES
Spain
Prior art keywords
substd
opt
alkylene
mercapto
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505545A
Other languages
English (en)
Other versions
ES505545A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of ES8306712A1 publication Critical patent/ES8306712A1/es
Publication of ES505545A0 publication Critical patent/ES505545A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AMINOACIDOS UTILES COMO AGENTES ANTIHIPERTENSORES. SE HACE REACCIONAR EL COMPUESTO (I) CON EL (II) PARA A CONTINUACION REPARAR EL GRUPO DE ESTER DE T-BUTILO PARA DAR ASI EL ACIDO LIBRE. A CONTINUACION SE HACE REACCIONAR EL COMPUESTO OBTENIDO CON EL COMPUESTO (III) CON EL QUE SE OBTIENE EL COMPUESTO (IV) DEL QUE SE SEPARA EL GRUPO DE BLOQUEO. SE OBTIENE EL COMPUESTO (V) EN QUE X E Y SON 1.
ES505545A 1980-09-17 1981-09-16 Un procedimiento para la preparacion de derivados de aminoacidos utiles como agentes antihipertensores. Granted ES505545A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18799280A 1980-09-17 1980-09-17

Publications (2)

Publication Number Publication Date
ES8306712A1 true ES8306712A1 (es) 1983-06-01
ES505545A0 ES505545A0 (es) 1983-06-01

Family

ID=22691337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505545A Granted ES505545A0 (es) 1980-09-17 1981-09-16 Un procedimiento para la preparacion de derivados de aminoacidos utiles como agentes antihipertensores.

Country Status (4)

Country Link
JP (1) JPS57126468A (es)
KR (1) KR830007515A (es)
ES (1) ES505545A0 (es)
ZA (1) ZA816292B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives

Also Published As

Publication number Publication date
KR830007515A (ko) 1983-10-21
ZA816292B (en) 1983-01-26
JPS57126468A (en) 1982-08-06
ES505545A0 (es) 1983-06-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202