ES8306023A1 - A tissue adhesive and a method of producing the same - Google Patents
A tissue adhesive and a method of producing the sameInfo
- Publication number
- ES8306023A1 ES8306023A1 ES514441A ES514441A ES8306023A1 ES 8306023 A1 ES8306023 A1 ES 8306023A1 ES 514441 A ES514441 A ES 514441A ES 514441 A ES514441 A ES 514441A ES 8306023 A1 ES8306023 A1 ES 8306023A1
- Authority
- ES
- Spain
- Prior art keywords
- fibrinogen
- factor xiii
- antibiotic
- tissue adhesive
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003106 tissue adhesive Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 108010071289 Factor XIII Proteins 0.000 abstract 5
- 108010049003 Fibrinogen Proteins 0.000 abstract 5
- 102000008946 Fibrinogen Human genes 0.000 abstract 5
- 229940012444 factor xiii Drugs 0.000 abstract 5
- 229940012952 fibrinogen Drugs 0.000 abstract 5
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 238000010257 thawing Methods 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A tissue adhesive based on human or animal proteins contains factor XIII, fibrinogen and an antibiotic. In order to achieve a high straining capacity of the adherences and a retarded antimicrobial efficacy, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, amounts to at least 500. The antibiotic is chosen among amino-glucosides, beta- lactams, polypeptides or tetracyclines. In a method of producing the tissue adhesive the concentration ratio of factor XIII to fibrinogen is adjusted in a fibrinogen-containing blood plasma fraction by the addition of factor XIII. The antibiotic is added either before deepfreezing or lyophilization of the resulting preparation, or after thawing or reconstitution of the same.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0333781A AT369990B (en) | 1981-07-28 | 1981-07-28 | METHOD FOR PRODUCING A TISSUE ADHESIVE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306023A1 true ES8306023A1 (en) | 1983-05-01 |
| ES514441A0 ES514441A0 (en) | 1983-05-01 |
Family
ID=3548998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES514441A Granted ES514441A0 (en) | 1981-07-28 | 1982-07-27 | PROCEDURE FOR THE MANUFACTURE OF A BINDER FOR TISSUES BASED ON HUMAN OR ANIMAL PROTEINS. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPH0696039B2 (en) |
| AR (1) | AR227252A1 (en) |
| AT (1) | AT369990B (en) |
| BE (1) | BE893851A (en) |
| CA (1) | CA1168982A (en) |
| CH (1) | CH659187B (en) |
| DE (1) | DE3225102A1 (en) |
| DK (1) | DK157977C (en) |
| ES (1) | ES514441A0 (en) |
| FR (1) | FR2510408B1 (en) |
| GB (1) | GB2102811B (en) |
| IT (1) | IT1157313B (en) |
| NL (1) | NL192665C (en) |
| SE (1) | SE459848B (en) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06102628B2 (en) * | 1984-03-27 | 1994-12-14 | イムノ・アクチエンゲゼルシャフト | Tissue adhesive manufacturing method |
| JPS6185304A (en) * | 1984-10-01 | 1986-04-30 | Green Cross Corp:The | Auxiliary for dental treatment |
| DE3622642A1 (en) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | ONE-COMPONENT TISSUE ADHESIVE AND METHOD FOR THE PRODUCTION THEREOF |
| AT397203B (en) * | 1988-05-31 | 1994-02-25 | Immuno Ag | FABRIC ADHESIVE |
| US4837379A (en) * | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
| NZ229385A (en) * | 1989-06-01 | 1992-02-25 | Life Technologies Inc | Treatment of processed fish product (surimi) with alpha-2-macroglobulin to neutralise alkaline proteases in the fish |
| IT1243180B (en) * | 1990-07-31 | 1994-05-24 | Nunzio Rapisarda | USE OF PHOSPHOMYCIN AND ITS SALTS AS A TOPICAL CICATRIZING AGENT |
| US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
| US7229959B1 (en) | 1990-11-27 | 2007-06-12 | The American National Red Cross | Supplemented fibrin matrix delivery systems |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| AU4566893A (en) * | 1992-07-18 | 1994-02-14 | Opperbas Holding B.V. | A two component fibrin-glue composition for improving in vitro fertilization |
| US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| EP0696201B2 (en) † | 1993-03-12 | 2012-09-19 | The American National Red Cross | Supplemented tissue sealants, methods of their production and use |
| US6019993A (en) * | 1993-03-30 | 2000-02-01 | Omrix Biopharmaceuticals S.A. | Virus-inactivated 2-component fibrin glue |
| DE19521324C1 (en) * | 1995-06-12 | 1996-10-31 | Immuno Ag | Tissue adhesive and use thereof as a hemostatic |
| DE19617369A1 (en) * | 1996-04-30 | 1997-11-06 | Immuno Ag | Storage-stable fibrinogen preparations |
| AT406120B (en) | 1997-08-28 | 2000-02-25 | Immuno Ag | TISSUE ADHESIVE |
| AT407484B (en) | 1997-11-12 | 2001-03-26 | Bio Prod & Bio Eng Ag | MEDICINES FOR PROMOTING Wound Healing |
| US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
| JP4660048B2 (en) | 1999-12-23 | 2011-03-30 | シーエスエル、リミテッド | Separation of fibrinogen from plasma protease |
| US6506365B1 (en) | 2000-09-25 | 2003-01-14 | Baxter Aktiengesellschaft | Fibrin/fibrinogen binding conjugate |
| IL144446A0 (en) * | 2001-07-19 | 2002-05-23 | Prochon Biotech Ltd | Plasma protein matrices and methods for their preparation |
| CA2498212C (en) | 2002-09-10 | 2012-07-17 | American National Red Cross | Multi-layered hemostatic dressing comprising thrombin and fibrinogen |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| JP2008510476A (en) | 2004-08-27 | 2008-04-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Purification of factor XIII polypeptide from biological material |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| WO2006056575A1 (en) | 2004-11-23 | 2006-06-01 | Zymogenetics, Inc. | Purification of recombinant human factor xiii |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| WO2008019129A2 (en) | 2006-08-04 | 2008-02-14 | Stb Lifesaving Technologies, Inc. | Solid dressing for treating wounded tissue |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20090075891A1 (en) | 2007-08-06 | 2009-03-19 | Macphee Martin | Methods and dressings for sealing internal injuries |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US20230210958A1 (en) | 2021-12-30 | 2023-07-06 | Baxter International Inc. | Fibrinogen and thrombin solutions for a fibrin sealant and fibrin sealant kit |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359652B (en) * | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
| AT359653B (en) * | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
| WO1981000516A1 (en) * | 1979-08-31 | 1981-03-05 | Merck Patent Gmbh | Gel containing fibrine and antibiotic for treating infected bones and preparation process thereof |
-
1981
- 1981-07-28 AT AT0333781A patent/AT369990B/en not_active IP Right Cessation
-
1982
- 1982-07-01 SE SE8204064A patent/SE459848B/en not_active IP Right Cessation
- 1982-07-05 DK DK300682A patent/DK157977C/en active
- 1982-07-05 DE DE19823225102 patent/DE3225102A1/en active Granted
- 1982-07-05 CH CH409482A patent/CH659187B/de unknown
- 1982-07-06 GB GB08219500A patent/GB2102811B/en not_active Expired
- 1982-07-13 CA CA000407154A patent/CA1168982A/en not_active Expired
- 1982-07-16 BE BE0/208601A patent/BE893851A/en not_active IP Right Cessation
- 1982-07-21 AR AR290039A patent/AR227252A1/en active
- 1982-07-22 JP JP57126829A patent/JPH0696039B2/en not_active Expired - Lifetime
- 1982-07-23 NL NL8202982A patent/NL192665C/en not_active IP Right Cessation
- 1982-07-23 FR FR8212918A patent/FR2510408B1/en not_active Expired
- 1982-07-27 IT IT22595/82A patent/IT1157313B/en active
- 1982-07-27 ES ES514441A patent/ES514441A0/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AT369990B (en) | 1983-02-25 |
| NL192665B (en) | 1997-08-01 |
| NL192665C (en) | 1997-12-02 |
| SE459848B (en) | 1989-08-14 |
| GB2102811B (en) | 1985-01-30 |
| IT1157313B (en) | 1987-02-11 |
| NL8202982A (en) | 1983-02-16 |
| JPS5826821A (en) | 1983-02-17 |
| JPH0696039B2 (en) | 1994-11-30 |
| DK157977C (en) | 1990-08-13 |
| FR2510408A1 (en) | 1983-02-04 |
| ES514441A0 (en) | 1983-05-01 |
| GB2102811A (en) | 1983-02-09 |
| DE3225102A1 (en) | 1983-02-17 |
| SE8204064D0 (en) | 1982-07-01 |
| CA1168982A (en) | 1984-06-12 |
| IT8222595A0 (en) | 1982-07-27 |
| CH659187B (en) | 1987-01-15 |
| DE3225102C2 (en) | 1990-05-31 |
| DK157977B (en) | 1990-03-12 |
| SE8204064L (en) | 1983-01-29 |
| FR2510408B1 (en) | 1987-02-27 |
| AR227252A1 (en) | 1982-09-30 |
| ATA333781A (en) | 1982-07-15 |
| DK300682A (en) | 1983-01-29 |
| BE893851A (en) | 1982-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20030212 |