ES8305360A1 - Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol - Google Patents

Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol

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Publication number
ES8305360A1
ES8305360A1 ES504263A ES504263A ES8305360A1 ES 8305360 A1 ES8305360 A1 ES 8305360A1 ES 504263 A ES504263 A ES 504263A ES 504263 A ES504263 A ES 504263A ES 8305360 A1 ES8305360 A1 ES 8305360A1
Authority
ES
Spain
Prior art keywords
isopropyl
ester
nortropan
yield
bromomethylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504263A
Other languages
English (en)
Other versions
ES504263A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Original Assignee
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Investigacion y Desarrollo Quimico Biologico SA filed Critical Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority to ES504263A priority Critical patent/ES504263A0/es
Publication of ES8305360A1 publication Critical patent/ES8305360A1/es
Publication of ES504263A0 publication Critical patent/ES504263A0/es
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE N-BROMOMETILATO DEL ESTER TROPICO DE N-ISOPROPIL-NORTROPAN 3 ~C-OIL. CONSISTE EN HACER REACCIONAR LA ISOPROPILAMINA CON ACIDO ACETONDICARBOXILICO Y 2,5 DIMETOXITETRAHIDROFURANO PARA DAR LA N-ISOPROPIL-3-NORTROPANONA QUE SE REDUCE CON HIDRURO DE ALUMINIO AL N-ISOPROPIL 3-NORTROPAN 3 ~C OL QUE SE PURIFICA MEDIANTE CROMATOGRAFIA EN COLUMNA CON FASE ESTACIONARIA Y QUE SE HACE REACCIONAR CON ESTER METILICO DEL ACIDO FENIL ACETICO PARA DAR EL ESTER FENILACETATO N-ISOPROPIL-NORTROPIN-3 ~C OL; ESTE SE FORMULA CON FORMIATO DE METILO EN PRESENCIA DE SODIO PARA DAR EL ESTER N-ISOPROPIL 3~C-NOTROPINICO DEL ACIDO ~C-FORMILFENIL ACETICO QUE SE REDUCE AL ESTER TROPICO CORRESPONDIENTE EL CUAL SE CUATERNIZA CON BROMURO DE METILO.
ES504263A 1981-07-24 1981-07-24 Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol Granted ES504263A0 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES504263A ES504263A0 (es) 1981-07-24 1981-07-24 Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES504263A ES504263A0 (es) 1981-07-24 1981-07-24 Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol

Publications (2)

Publication Number Publication Date
ES8305360A1 true ES8305360A1 (es) 1983-04-01
ES504263A0 ES504263A0 (es) 1983-04-01

Family

ID=8482752

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504263A Granted ES504263A0 (es) 1981-07-24 1981-07-24 Procedimiento para la sintesis de n-bromometilato del ester tropico del n-isopropil-nortropan-3a-ol

Country Status (1)

Country Link
ES (1) ES504263A0 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349238A (zh) * 2016-08-24 2017-01-25 山东省药学科学院 一种异丙托溴铵的制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349238A (zh) * 2016-08-24 2017-01-25 山东省药学科学院 一种异丙托溴铵的制备方法

Also Published As

Publication number Publication date
ES504263A0 (es) 1983-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202