ES8304559A1 - "procedimiento para la fabricacion de sales de naftidrofurilo". - Google Patents
"procedimiento para la fabricacion de sales de naftidrofurilo".Info
- Publication number
- ES8304559A1 ES8304559A1 ES512819A ES512819A ES8304559A1 ES 8304559 A1 ES8304559 A1 ES 8304559A1 ES 512819 A ES512819 A ES 512819A ES 512819 A ES512819 A ES 512819A ES 8304559 A1 ES8304559 A1 ES 8304559A1
- Authority
- ES
- Spain
- Prior art keywords
- naftidrofuryl
- therapeutic use
- citrate
- naftidrofuryl citrate
- properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE SALES DE NAFTIDROFURILO, POR SALIFICACION DE LA BASE LIBRE, UTILIZANDO ACIDO CITRICO MONOHIDRATADO. CONSISTE EN LA REACCION DE ACETONA, ACETATO DE ETILO, NAFTIDROFURILO BASE Y ACIDO CITRICO MONOHIDRATADO, EN PROPORCION VOLUMETRICA DE ACETONA Y ACETATO DE ETILO 1:1, Y EN PROPORCIONES EQUIMOLECULARES DE NAFTIDROFURILO Y ACIDO CITRICO. LA MEZCLA DE REACCION SE SOMETE A CALENTAMIENTO A REFLUJO; POSTERIORMENTE SE ENFRIA A 5 C Y EL PRODUCTO OBTENIDO SE SEPARA POR FILTRACION. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SUS EFECTOS CARDIORESPIRATORIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8109590A FR2505836A1 (fr) | 1981-05-14 | 1981-05-14 | Citrate de naftidrofuryl et son application therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8304559A1 true ES8304559A1 (es) | 1983-03-01 |
ES512819A0 ES512819A0 (es) | 1983-03-01 |
Family
ID=9258433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512819A Granted ES512819A0 (es) | 1981-05-14 | 1982-05-14 | "procedimiento para la fabricacion de sales de naftidrofurilo". |
Country Status (22)
Country | Link |
---|---|
US (1) | US4439442A (es) |
EP (1) | EP0065446B1 (es) |
JP (1) | JPS57203078A (es) |
KR (1) | KR830010091A (es) |
AT (1) | ATE9342T1 (es) |
AU (1) | AU8373282A (es) |
CA (1) | CA1184562A (es) |
CS (1) | CS239923B2 (es) |
DD (1) | DD202432A5 (es) |
DE (1) | DE3260712D1 (es) |
DK (1) | DK210982A (es) |
ES (1) | ES512819A0 (es) |
FI (1) | FI821664L (es) |
FR (1) | FR2505836A1 (es) |
GR (1) | GR75422B (es) |
HU (1) | HU187701B (es) |
IL (1) | IL65774A (es) |
NZ (1) | NZ200594A (es) |
PT (1) | PT74893B (es) |
SU (1) | SU1082323A3 (es) |
YU (1) | YU103082A (es) |
ZA (1) | ZA823195B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2580502B1 (fr) * | 1985-04-23 | 1988-07-08 | Lipha | Emploi du " naftidrofuryl " dans la preparation d'un medicament |
TW200920348A (en) * | 2007-06-28 | 2009-05-16 | Dybly Ag | Combination of picotamide with nafronyl |
US8203109B2 (en) | 2009-05-08 | 2012-06-19 | Raytheon Company | High energy laser beam director system and method |
CN104086515A (zh) * | 2014-06-13 | 2014-10-08 | 刘博� | 萘呋胺酯草酸盐的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL142872C (es) * | 1963-03-28 | |||
FR3843M (fr) * | 1964-03-17 | 1966-01-17 | Lipha | Nouvelles bases azotées a propriétés antispasmodique et vasodilatatrice. |
-
1981
- 1981-05-14 FR FR8109590A patent/FR2505836A1/fr active Granted
-
1982
- 1982-04-27 GR GR67998A patent/GR75422B/el unknown
- 1982-04-30 EP EP82400799A patent/EP0065446B1/fr not_active Expired
- 1982-04-30 AT AT82400799T patent/ATE9342T1/de active
- 1982-04-30 DE DE8282400799T patent/DE3260712D1/de not_active Expired
- 1982-05-10 ZA ZA823195A patent/ZA823195B/xx unknown
- 1982-05-11 DK DK210982A patent/DK210982A/da not_active Application Discontinuation
- 1982-05-11 FI FI821664A patent/FI821664L/fi not_active Application Discontinuation
- 1982-05-12 CS CS823459A patent/CS239923B2/cs unknown
- 1982-05-12 CA CA000402771A patent/CA1184562A/fr not_active Expired
- 1982-05-12 PT PT74893A patent/PT74893B/pt unknown
- 1982-05-13 SU SU823444131A patent/SU1082323A3/ru active
- 1982-05-13 NZ NZ200594A patent/NZ200594A/en unknown
- 1982-05-13 HU HU821501A patent/HU187701B/hu unknown
- 1982-05-14 US US06/378,333 patent/US4439442A/en not_active Expired - Fee Related
- 1982-05-14 ES ES512819A patent/ES512819A0/es active Granted
- 1982-05-14 KR KR1019820002100A patent/KR830010091A/ko unknown
- 1982-05-14 DD DD82239879A patent/DD202432A5/de unknown
- 1982-05-14 JP JP57081336A patent/JPS57203078A/ja active Pending
- 1982-05-14 AU AU83732/82A patent/AU8373282A/en not_active Abandoned
- 1982-05-14 IL IL65774A patent/IL65774A/xx unknown
- 1982-05-14 YU YU01030/82A patent/YU103082A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL65774A0 (en) | 1982-08-31 |
GR75422B (es) | 1984-07-16 |
DK210982A (da) | 1982-11-15 |
AU8373282A (en) | 1982-11-18 |
PT74893A (fr) | 1982-06-01 |
US4439442B1 (es) | 1987-06-30 |
EP0065446B1 (fr) | 1984-09-12 |
FI821664L (fi) | 1982-11-15 |
SU1082323A3 (ru) | 1984-03-23 |
DD202432A5 (de) | 1983-09-14 |
CA1184562A (fr) | 1985-03-26 |
ZA823195B (en) | 1983-03-30 |
CS239923B2 (en) | 1986-01-16 |
HU187701B (en) | 1986-02-28 |
YU103082A (en) | 1984-08-31 |
IL65774A (en) | 1985-09-29 |
NZ200594A (en) | 1985-03-20 |
US4439442A (en) | 1984-03-27 |
DE3260712D1 (en) | 1984-10-18 |
EP0065446A1 (fr) | 1982-11-24 |
FI821664A0 (fi) | 1982-05-11 |
FR2505836A1 (fr) | 1982-11-19 |
JPS57203078A (en) | 1982-12-13 |
KR830010091A (ko) | 1983-12-26 |
ATE9342T1 (de) | 1984-09-15 |
PT74893B (fr) | 1983-12-23 |
FR2505836B1 (es) | 1984-03-09 |
ES512819A0 (es) | 1983-03-01 |
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