ES8301204A1 - Process for the production of a dipeptide amide of an L-aspartyl-D-amino acid - Google Patents
Process for the production of a dipeptide amide of an L-aspartyl-D-amino acidInfo
- Publication number
- ES8301204A1 ES8301204A1 ES508348A ES508348A ES8301204A1 ES 8301204 A1 ES8301204 A1 ES 8301204A1 ES 508348 A ES508348 A ES 508348A ES 508348 A ES508348 A ES 508348A ES 8301204 A1 ES8301204 A1 ES 8301204A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- ethyl
- methyl
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Amides of dipeptides of L-aspartyl-D-amino acids of formula < IMAGE > and their cationic and addition salts with physiologically acceptable acids where Ra is methyl, ethyl, n-propyl or isopropyl, R is a branched radical selected from the group comprising phenyl, diisopropyl carbinyl, d-methyl-t-butyl carbinyl, d-ethyl-t-butyl carbinyl, di-t-butyl carbinyl, 2-methylthio-2,4- dimethylpentane-3-yl < IMAGE > where at least one of the radicals R3, R4, R5 or R6 is alkyl having from 1 to 4 carbon atoms and the remainder are hydrogen or alkyl having from 1 to 4 carbon atoms, X is O, S, SO, SO2, C=O or CHOH, m is 0 or 1-4, n and p are each 0, 1, 2, or 3 and the sum of n + p is not greater than 3 and the sum of the carbon atoms in R3, R4, R5 and R6 is not greater than 6 and when R3 and R4 or R5 and R6 are both alkyl, they are then methyl or ethyl, < IMAGE > where one of the radicals R7, R8 or R9 is alkyl having from 1 to 4 carbon atoms and the remainder are hydrogen or alkyl having from 1 to 4 carbon atoms and the sum of the carbon atoms in R7, R8 and R9 is not greater than 6, m and q are the same or different and each has the values previously specified for m, < IMAGE > where each of the radicals R12 and R13 is methyl or ethyl or R12 is hydrogen and R13 is alkyl having from 1 to 4 carbon atoms, Z is O or NH and t is 1 or 2, < IMAGE > where w is 1-4, R14 and R16 are each alkyl having from 1 to 4 carbon atoms, R15 is H, OH, methyl or ethyl and the sum of the carbon atoms in R14, R15 and R16 is not greater than 6 and when R14 and R15 are both alkyl, then they are methyl or ethyl and < IMAGE > where R17 and R19 are alkyl having from 1 to 4 carbon atoms, R18 and R20 are H or alkyl with 1 or 2 carbon atoms, A is OH and B is H, OH or CH3 and when joined together A and B are < IMAGE > where the sum of the carbon atoms in R17, R18, R19 and R20 is not greater than 6 and when R17 and R18 or R19 and R20 are both alkyl then they are methyl or ethyl these amides are powerful sweeteners which have advantages over those in the prior art edible compositions containing these amides, methods for their use in edible compositions and new intermediate amines and amides useful for their production.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11380080A | 1980-01-21 | 1980-01-21 | |
| US06/201,745 US4411925A (en) | 1980-01-21 | 1980-11-05 | Branched amides of L-aspartyl-d-amino acid dipeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301204A1 true ES8301204A1 (en) | 1982-11-16 |
| ES508348A0 ES508348A0 (en) | 1982-11-16 |
Family
ID=26811494
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498681A Expired ES8204413A1 (en) | 1980-01-21 | 1981-01-20 | Process for the production of a dipeptide amide of an L-aspartyl-D-amino acid |
| ES508348A Granted ES508348A0 (en) | 1980-01-21 | 1981-12-24 | A PROCEDURE FOR THE PREPARATION OF AN AMINE. |
| ES508349A Expired ES8300686A1 (en) | 1980-01-21 | 1981-12-24 | Process for the production of a dipeptide amide of an L-aspartyl-D-amino acid |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498681A Expired ES8204413A1 (en) | 1980-01-21 | 1981-01-20 | Process for the production of a dipeptide amide of an L-aspartyl-D-amino acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508349A Expired ES8300686A1 (en) | 1980-01-21 | 1981-12-24 | Process for the production of a dipeptide amide of an L-aspartyl-D-amino acid |
Country Status (11)
| Country | Link |
|---|---|
| DE (1) | DE3165719D1 (en) |
| ES (3) | ES8204413A1 (en) |
| GR (1) | GR73520B (en) |
| IE (1) | IE50915B1 (en) |
| IL (1) | IL61926A (en) |
| MX (3) | MX5981E (en) |
| MY (1) | MY8600633A (en) |
| NO (1) | NO156411C (en) |
| NZ (1) | NZ196037A (en) |
| PT (1) | PT72355B (en) |
| YU (3) | YU44817B (en) |
-
1981
- 1981-01-08 DE DE8181300066T patent/DE3165719D1/en not_active Expired
- 1981-01-15 PT PT72355A patent/PT72355B/en unknown
- 1981-01-16 NZ NZ196037A patent/NZ196037A/en unknown
- 1981-01-19 IL IL61926A patent/IL61926A/en not_active IP Right Cessation
- 1981-01-19 GR GR63908A patent/GR73520B/el unknown
- 1981-01-20 MX MX819274U patent/MX5981E/en unknown
- 1981-01-20 YU YU138/81A patent/YU44817B/en unknown
- 1981-01-20 IE IE92/81A patent/IE50915B1/en not_active IP Right Cessation
- 1981-01-20 NO NO810171A patent/NO156411C/en not_active IP Right Cessation
- 1981-01-20 ES ES498681A patent/ES8204413A1/en not_active Expired
- 1981-01-20 MX MX8111235U patent/MX7646E/en unknown
- 1981-01-20 MX MX8111234U patent/MX7624E/en unknown
- 1981-12-24 ES ES508348A patent/ES508348A0/en active Granted
- 1981-12-24 ES ES508349A patent/ES8300686A1/en not_active Expired
-
1983
- 1983-08-15 YU YU1695/83A patent/YU44749B/en unknown
- 1983-08-15 YU YU1694/83A patent/YU44856B/en unknown
-
1986
- 1986-12-30 MY MY633/86A patent/MY8600633A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO156411C (en) | 1987-09-16 |
| YU169483A (en) | 1984-04-30 |
| ES498681A0 (en) | 1982-05-01 |
| MX7624E (en) | 1990-03-27 |
| ES508348A0 (en) | 1982-11-16 |
| YU44856B (en) | 1991-04-30 |
| MX5981E (en) | 1984-09-12 |
| YU44749B (en) | 1991-02-28 |
| ES8204413A1 (en) | 1982-05-01 |
| MX7646E (en) | 1990-05-30 |
| GR73520B (en) | 1984-03-09 |
| PT72355B (en) | 1982-07-23 |
| YU169583A (en) | 1984-04-30 |
| YU44817B (en) | 1991-02-28 |
| MY8600633A (en) | 1986-12-31 |
| DE3165719D1 (en) | 1984-10-04 |
| PT72355A (en) | 1981-02-01 |
| IL61926A0 (en) | 1981-02-27 |
| NO810171L (en) | 1981-07-22 |
| NO156411B (en) | 1987-06-09 |
| YU13881A (en) | 1984-04-30 |
| IE810092L (en) | 1981-07-21 |
| IE50915B1 (en) | 1986-08-20 |
| ES508349A0 (en) | 1982-11-16 |
| IL61926A (en) | 1984-07-31 |
| ES8300686A1 (en) | 1982-11-16 |
| NZ196037A (en) | 1984-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20100528 |