ES8300759A1 - Procedure for obtaining a derivative of 1,2-benzotizazine. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for obtaining a derivative of 1,2-benzotizazine. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Ferrer Internacional SA
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Ferrer Internacional SA
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Priority to ES508671ApriorityCriticalpatent/ES508671A0/en
Publication of ES8300759A1publicationCriticalpatent/ES8300759A1/en
Publication of ES508671A0publicationCriticalpatent/ES508671A0/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedure for the obtaining of a derivative of formula 1,2-benzotiazine (I). It consists of the reaction of a compound of formula (II) with a strong base, such as metoxide or sodium etoxide in dimethylformamide at a temperature of not less than 50º c; following reaction with an excessive light of sodium hydride in dimethylformamide; addition of methyl yodide; cooling with water-ice; filtration; treatment of the solid product with hydrogen peroxide in water and sodium or potassic hydroxide to reflux, washing and vapor evaporation; treatment of reflux with 2-amino-pyridine in xylene, elimination of xylene, acidification, filtration and purification. > this composite has pharmacological applications for its anti-inflammatory and antirreumatic activity. (Machine-translation by Google Translate, not legally binding)
ES508671A1981-12-211981-12-21
"PROCEDURE FOR OBTAINING A DERIVATIVE OF 1,2-BENZOTIAZINE".
GrantedES508671A0
(en)
Improvements in the construction of appliances for the application of electroacupuncture (Machine-translation by Google Translate, not legally binding)