ES8300758A1 - Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas. - Google Patents

Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas.

Info

Publication number
ES8300758A1
ES8300758A1 ES503308A ES503308A ES8300758A1 ES 8300758 A1 ES8300758 A1 ES 8300758A1 ES 503308 A ES503308 A ES 503308A ES 503308 A ES503308 A ES 503308A ES 8300758 A1 ES8300758 A1 ES 8300758A1
Authority
ES
Spain
Prior art keywords
same
ones
oxadiazol
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503308A
Other languages
English (en)
Spanish (es)
Other versions
ES503308A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES503308A0 publication Critical patent/ES503308A0/es
Publication of ES8300758A1 publication Critical patent/ES8300758A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES503308A 1980-06-27 1981-06-23 Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas. Expired ES8300758A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/163,614 US4309430A (en) 1980-06-27 1980-06-27 Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same

Publications (2)

Publication Number Publication Date
ES503308A0 ES503308A0 (es) 1982-11-01
ES8300758A1 true ES8300758A1 (es) 1982-11-01

Family

ID=22590790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503308A Expired ES8300758A1 (es) 1980-06-27 1981-06-23 Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas.

Country Status (10)

Country Link
US (1) US4309430A (h)
EP (1) EP0043123B1 (h)
JP (1) JPS5756480A (h)
AT (1) ATE7697T1 (h)
DE (1) DE3163867D1 (h)
DK (1) DK283881A (h)
ES (1) ES8300758A1 (h)
GR (1) GR74609B (h)
IE (1) IE51342B1 (h)
PT (1) PT73259B (h)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066662A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors
JP5702293B2 (ja) 2008-11-10 2015-04-15 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
CA2747252C (en) 2008-12-19 2018-09-18 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
WO2011143419A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
US9062008B2 (en) 2010-05-12 2015-06-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2568984A1 (en) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US9334244B2 (en) 2010-05-12 2016-05-10 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CA2798763A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CN102947272A (zh) 2010-05-12 2013-02-27 沃泰克斯药物股份有限公司 用作atr激酶抑制剂的2-氨基吡啶衍生物
EP2585468A1 (en) 2010-06-23 2013-05-01 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
WO2012138938A1 (en) 2011-04-05 2012-10-11 Vertex Pharmaceuticals Incorporated Aminopyrazine compounds useful as inhibitors of tra kinase
JP2014522818A (ja) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US8822469B2 (en) 2011-06-22 2014-09-02 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
EP2723746A1 (en) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
EP3878851A1 (en) 2011-09-30 2021-09-15 Vertex Pharmaceuticals Incorporated Process for making compounds useful as inhibitors of atr kinase
WO2013049720A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
IN2014KN00943A (h) 2011-09-30 2015-08-21 Vertex Pharma
SG11201401095YA (en) 2011-09-30 2014-04-28 Vertex Pharma Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors
US8765751B2 (en) 2011-09-30 2014-07-01 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2013071088A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2776429A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071093A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
WO2013071090A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US8841449B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
NZ726671A (en) 2012-04-05 2018-04-27 Vertex Pharma Compounds useful as inhibitors of atr kinase and combination therapies thereof
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
US8912198B2 (en) 2012-10-16 2014-12-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CN104903325B (zh) 2012-12-07 2017-10-20 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物
JP2016512815A (ja) 2013-03-15 2016-05-09 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体
SI3077397T1 (sl) 2013-12-06 2020-02-28 Vertex Pharmaceuticals Inc. 2-amino-6-fluoro-N-(5-fluoro-piridin-3-IL)pirazolo(1,5-A)pirimidin-3- karboksamidna spojina, koristna kot inhibitor kinaze ATR, njena priprava, različne trdne oblike in njeni radioaktivno označeni derivati
AU2015271030B2 (en) 2014-06-05 2019-05-16 Vertex Pharmaceuticals Incorporated Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof
RU2736219C2 (ru) 2014-06-17 2020-11-12 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации ингибиторов снк1 и atr
HK1258570A1 (zh) 2015-09-30 2019-11-15 Vertex Pharmaceuticals Inc. 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3515723A (en) * 1967-11-14 1970-06-02 Merck & Co Inc 2 - (5 - amino - 1h - 1,2,4 - triazol - 3 - yl)- 3-aminopyrazines and processes for their preparation
US3770739A (en) * 1972-09-11 1973-11-06 American Cyanamid Co Cyclorpropyl-1,2,4-oxadiazolylpyrazines

Also Published As

Publication number Publication date
ES503308A0 (es) 1982-11-01
ATE7697T1 (de) 1984-06-15
IE51342B1 (en) 1986-12-10
EP0043123B1 (en) 1984-05-30
DK283881A (da) 1981-12-28
EP0043123A1 (en) 1982-01-06
JPS5756480A (en) 1982-04-05
DE3163867D1 (en) 1984-07-05
PT73259B (en) 1983-06-28
GR74609B (h) 1984-06-29
PT73259A (en) 1981-07-01
US4309430A (en) 1982-01-05
IE811431L (en) 1981-12-27

Similar Documents

Publication Publication Date Title
ES8300758A1 (es) Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas.
PT73200A (en) Process for preparing novel antihistamines
ES8405396A1 (es) Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles.
GB2023613B (en) Process for the treatment of collagen-containing materials
PT73388B (en) Process for preparing antiinflammatory 4,5-diaryl-alfa-poly- fluoroalkyl-1h-imidazole-2-methanamides and pharmaceutical compositions containing the same
DE3171564D1 (en) Process for the synthesis of alpha-chlorinated chloroformiates, and novel alpha-chlorinated chloroformiates
BG42004A3 (en) Method for preparing pyridyl compounds
DE3172006D1 (en) Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
DE2962315D1 (en) Process for the preparation of 2,2,6,6-tetramethyl-piperidone-(4)
DE2960357D1 (en) Substituted cyanamides, process for their preparation and their use as fungicides
DE3063315D1 (en) Process for the production of 2,6-dialkylcyclohexylamines
GB2165258B (en) Process for preparing n,n' disubstituted nitro-para-phenylenediamines, compounds obtained thereby and dyeing compositions containing the same
DE2964590D1 (en) Heterotricyclic compounds, processes for their production and pharmaceutical compositions containing them
ES8302675A1 (es) "procedimiento para la preparacion de 1,2 benzisoxazoloxietilaminas".
ES473316A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas.
DE3161613D1 (en) Process for the production of 3-mercapto-propanediol-(1,2)
DE3060102D1 (en) Process for production of 1,17-diamino-9-azaheptadecane
DE3062872D1 (en) Process for the production of glazing-pigment forms of 4,4',7,7'-tetrachlorothio indigo
DE3160959D1 (en) Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds
IL63247A0 (en) Process for the manufacture of 2,6-dichlorobenzoxazole and 2,6 dichlorobenzthiazole
DE3160037D1 (en) Process for the preparation of 2,4,6-trifluorotriazine-(1,3,5)
DE3160222D1 (en) Process for the preparation of 2,6-xylidine
GB2013663B (en) Process for the production of 2,4-difluoro-6-amino-s-triazine
PT69540A (en) Process for preparing 1,4-bis-piperonylpiperazine and similar compounds
DE3067027D1 (en) Process for the preparation of 1,4-dialkylbut-2-ene-1,4-diones