ES8207130A1 - Un metodo para la preparacion de derivados del acido prope- noico. - Google Patents

Un metodo para la preparacion de derivados del acido prope- noico.

Info

Publication number
ES8207130A1
ES8207130A1 ES506895A ES506895A ES8207130A1 ES 8207130 A1 ES8207130 A1 ES 8207130A1 ES 506895 A ES506895 A ES 506895A ES 506895 A ES506895 A ES 506895A ES 8207130 A1 ES8207130 A1 ES 8207130A1
Authority
ES
Spain
Prior art keywords
propenoate
lactam
beta
type compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506895A
Other languages
English (en)
Other versions
ES506895A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES506895A0 publication Critical patent/ES506895A0/es
Publication of ES8207130A1 publication Critical patent/ES8207130A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN METODO PARA LA PREPACION DE DERIVADO DE ACIDO PROPENOICO. CONSTA DE LAS SIGUIENTES ETAPAS: 1. REACCION DE UN ESTER T-BUTILICO DE UN ALFA-AMINOACIDO CON UNCLORURO DE ACIDO DE FORMULA R2COCL, EN PRESENCIA DEUNA BASE Y DE UN DISOLVENTE INERTE; SE OBTIENE EL CORRESPONDIENTE DERIVADO ACILADO. 2. OXIDACION DEL PRODUCTO OBTEIDO POR TRATAMIENTO CON HIPOCLORITO DE TERC-BUTILO Y POSTERIORMENTE AÑADIR METOXIDO SODICO. 3. REACCION DE LA MEZCLA DE COMPUESTOS OBTENIDOS (I) Y (II) CON ACIDO CLORHIDRICO ANHIDRO. 4. OPCIONALMENTE ESTERIFICAR O SALIFICAR LOS COMPUESTOS OBTENIDOS. SE OBTIENEN COMPUESTOS DE FORMULA GENERAL (III), EN QUE R2 Y R3 PUEDEN SER RADICALES HIDROCARBONATADOS DE 3 A 10 Y DE 1 A 15 ATOMOS DE CARBONO, RESPECTIVAMENTE.
ES506895A 1979-11-02 1981-11-05 Un metodo para la preparacion de derivados del acido prope- noico. Expired ES8207130A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9079379A 1979-11-02 1979-11-02

Publications (2)

Publication Number Publication Date
ES506895A0 ES506895A0 (es) 1982-09-01
ES8207130A1 true ES8207130A1 (es) 1982-09-01

Family

ID=22224340

Family Applications (2)

Application Number Title Priority Date Filing Date
ES496446A Expired ES8201954A1 (es) 1979-11-02 1980-10-31 Un metodo para la preparacion de derivados del acido prope- noico.
ES506895A Expired ES8207130A1 (es) 1979-11-02 1981-11-05 Un metodo para la preparacion de derivados del acido prope- noico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES496446A Expired ES8201954A1 (es) 1979-11-02 1980-10-31 Un metodo para la preparacion de derivados del acido prope- noico.

Country Status (9)

Country Link
EP (1) EP0028778B1 (es)
JP (1) JPS5681518A (es)
AT (1) ATE11221T1 (es)
DE (1) DE3069986D1 (es)
DK (1) DK462580A (es)
ES (2) ES8201954A1 (es)
GR (1) GR70784B (es)
IE (1) IE50333B1 (es)
PT (1) PT72006B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
DE48025T1 (de) * 1980-09-17 1983-03-17 Merck & Co., Inc., 07065 Rahway, N.J. Z-omega-(substituierte) 2-(cyclopropan-carboxamido)-2-alkensaeuren, deren ester und salze und diese enthaltende antibakterielle zusammensetzungen und eine verbindung der thienamycin-gattung.
EP0086590A1 (en) * 1982-02-17 1983-08-24 Beecham Group Plc Antibacterial agents, their preparation and use
DE3569725D1 (en) * 1984-02-28 1989-06-01 Sumitomo Chemical Co A method for the optical purification of an optically active 2,2-dimethylcyclopropanecarboxylic acid amide
EP0161546B1 (en) * 1984-04-30 1989-12-13 Merck & Co. Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
FR2601946B1 (fr) * 1986-07-25 1988-10-21 Rhone Poulenc Chimie Procede de preparation de perfluoroalkylcetones
JPS63290860A (ja) * 1987-05-22 1988-11-28 Sanraku Inc アミノエチルシステイン誘導体
ATE217195T1 (de) * 1991-02-01 2002-05-15 Suntory Ltd Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3498979A (en) * 1967-04-03 1970-03-03 Glaxo Lab Ltd Recovery of n-(7-2'-thienylacetamidoceph-3-em-3-ylmethyl) pyridinium - 4-carboxylate from an acid addition salt thereof
FR2272684A1 (en) * 1975-01-07 1975-12-26 Ito Shojiro Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
AR244550A1 (es) * 1978-07-24 1993-11-30 Merck & Co Inc Procedimiento para obtener una composicion de antibioticos del tipo de la tienamicina con inhibidores de la dipeptidasa

Also Published As

Publication number Publication date
IE802249L (en) 1981-05-02
JPS5681518A (en) 1981-07-03
ES496446A0 (es) 1982-01-16
DE3069986D1 (en) 1985-02-28
ES506895A0 (es) 1982-09-01
ATE11221T1 (de) 1985-02-15
IE50333B1 (en) 1986-04-02
ES8201954A1 (es) 1982-01-16
EP0028778A1 (en) 1981-05-20
PT72006A (en) 1980-11-01
EP0028778B1 (en) 1985-01-16
PT72006B (en) 1984-05-29
GR70784B (es) 1983-03-23
DK462580A (da) 1981-05-03

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