ES8206449A1 - Procedimiento para la obtencion de un tripeptido de accion antitumoral. - Google Patents

Procedimiento para la obtencion de un tripeptido de accion antitumoral.

Info

Publication number
ES8206449A1
ES8206449A1 ES506871A ES506871A ES8206449A1 ES 8206449 A1 ES8206449 A1 ES 8206449A1 ES 506871 A ES506871 A ES 506871A ES 506871 A ES506871 A ES 506871A ES 8206449 A1 ES8206449 A1 ES 8206449A1
Authority
ES
Spain
Prior art keywords
chloroethyl
derivatives
antitumour activity
amino acids
aminophenyl alanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506871A
Other languages
English (en)
Spanish (es)
Other versions
ES506871A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proter SpA
Original Assignee
Proter SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proter SpA filed Critical Proter SpA
Publication of ES506871A0 publication Critical patent/ES506871A0/es
Publication of ES8206449A1 publication Critical patent/ES8206449A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES506871A 1980-11-28 1981-11-05 Procedimiento para la obtencion de un tripeptido de accion antitumoral. Expired ES8206449A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26305/80A IT1134503B (it) 1980-11-28 1980-11-28 Composti della diclorodietilaminofenilalanina ad azione antitumorale

Publications (2)

Publication Number Publication Date
ES506871A0 ES506871A0 (es) 1982-08-16
ES8206449A1 true ES8206449A1 (es) 1982-08-16

Family

ID=11219187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506871A Expired ES8206449A1 (es) 1980-11-28 1981-11-05 Procedimiento para la obtencion de un tripeptido de accion antitumoral.

Country Status (11)

Country Link
US (1) US4428875A (2)
EP (1) EP0056565B1 (2)
JP (1) JPS57120559A (2)
AT (1) ATE10621T1 (2)
AU (1) AU547065B2 (2)
CA (1) CA1180697A (2)
DE (1) DE3167653D1 (2)
ES (1) ES8206449A1 (2)
IL (1) IL64332A0 (2)
IT (1) IT1134503B (2)
PT (1) PT73950B (2)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714683A (en) * 1985-01-25 1987-12-22 Oncogen Polypeptide tumor inhibitors and antibodies thereto
US4777270A (en) * 1985-01-25 1988-10-11 Pfizer Inc. Macrocyclic polyether carboxylic acids
US5011777A (en) * 1985-01-25 1991-04-30 Oncogen Vectors encoding brain derivable polypeptide factors
US4921941A (en) * 1987-07-01 1990-05-01 Schering Corporation Orally active antiandrogens
US4902781A (en) * 1987-11-24 1990-02-20 Taisho Pharmaceutical Co., Ltd. Novel tripetide derivatives
GR1000608B (el) * 1988-07-21 1992-08-31 Erba Carlo Spa Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
JPH03118130U (2) * 1990-03-16 1991-12-05
JPH0727940U (ja) * 1993-10-29 1995-05-23 盟和産業株式会社 車輌用フロアマット
US6992207B2 (en) * 2000-06-13 2006-01-31 Oncopeptides Ab Melphalan derivatives and their use as cancer chemotherapeutic drugs
CN100491339C (zh) * 2007-04-20 2009-05-27 苏州市立德化学有限公司 一种抗肿瘤药物美法仑的合成工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU452986B2 (en) * 1971-11-03 1974-09-19 Istituto Sieroterapico Milanese Serafino Belfanti OLIGOPEPTIDES CONTAINING m-jpi (2 CHLORETHYL) AMINO] L-PHENYLALANINE
DE2510634A1 (de) 1975-03-12 1976-09-23 Boehringer Mannheim Gmbh L-3-(3,4-dihydroxy-phenyl)-2- methyl-alanin-peptide und verfahren zu deren herstellung
FR2381023A1 (fr) 1977-02-18 1978-09-15 Delalande Sa Nouveaux oligopeptides trifluoromethyles derives de la l-alanine, leur procede de preparation et leur application en therapeutique
US4216208A (en) * 1978-07-31 1980-08-05 Proter S.P.A. N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity

Also Published As

Publication number Publication date
JPH0243727B2 (2) 1990-10-01
ES506871A0 (es) 1982-08-16
JPS57120559A (en) 1982-07-27
CA1180697A (en) 1985-01-08
US4428875A (en) 1984-01-31
IT8026305A0 (it) 1980-11-28
DE3167653D1 (en) 1985-01-17
EP0056565A1 (en) 1982-07-28
IT1134503B (it) 1986-08-13
PT73950A (fr) 1981-12-01
EP0056565B1 (en) 1984-12-05
AU7739781A (en) 1982-06-03
PT73950B (fr) 1983-04-18
AU547065B2 (en) 1985-10-03
ATE10621T1 (de) 1984-12-15
IL64332A0 (en) 1982-02-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201